Parent-adolescent interactions, gender, and substance use: Brain mechanisms.

父母与青少年的互动、性别和物质使用:大脑机制。

基本信息

  • 批准号:
    10390274
  • 负责人:
  • 金额:
    $ 47.32万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-09-15 至 2024-04-30
  • 项目状态:
    已结题

项目摘要

Abstract (30 lines) Adolescent substance use is a significant public health problem that predicts future substance use disorders in adulthood. Precise understanding of risk factors is needed to develop and target preventions. A large body of research has identified the parenting environment as a strong risk factor for adolescent substance use. However, the brain mechanisms for effects of parenting on substance use are not known. In our current NIDA-funded R01 study, we found that maladaptive parenting behaviors measured in our novel laboratory parent-adolescent interaction task (PAIT) significantly predicted current and future (1 year later) substance use in 245 early adolescents. As a next step, in this R01 renewal application, we propose to team with a neuroscientist (co-PI Thompson) to investigate emotion- and reward-related brain mechanisms of effects of parenting on adolescent substance use. We conducted a pilot fMRI study with 72 of the adolescents from the R01 study and found initial evidence that observed parenting behaviors in the laboratory PAIT task predicted altered fronto-limbic-striatal activation to negative emotion and reward and that these brain responses predicted future adolescent substance use. Further, we found that these brain pathways differed by gender, with girls showing a pathway characterized by heightened fronto-limbic activation to negative emotion and boys showing a pathway characterized by heightened fronto-striatal activation to reward. The proposed renewal study will formally examine gender-differentiated brain pathways from parenting to adolescent substance use in a large sample with a greater range of parenting behavior. We will recruit 326 substance-naive 11-12 year olds and their parents, with 40% oversampled for maladaptive parenting. In a laboratory session, we will measure observed parenting behaviors and adolescent physiological responses in our PAIT task, validated in the current R01 study. Adolescents will complete fMRI sessions to examine brain functional activation (and also functional connectivity) in standardized emotion processing, reward processing, and resting-state tasks which we piloted in the current R01 sample. We will collect detailed behavioral and biological measures of substance use and problem use, emotion and reward sensitivity, and reported parenting at baseline and 1, 2, and 3 year follow-ups into middle adolescence. We will examine: 1. Parenting in PAIT predicting adolescent emotion- and reward-related brain function by gender and 2. Adolescent brain function predicting increases in substance use over three years, by gender. The study will be the first to integrate laboratory assessment of parenting with neuro- imaging to understand brain-based mechanisms of parenting effects on substance use. By identifying brain mechanisms of parenting effects, and gender differences in these, we can better target and strengthen parenting-focused prevention programs and develop gender-sensitive preventions.
摘要(30行)

项目成果

期刊论文数量(0)
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会议论文数量(0)
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Tara M Chaplin其他文献

Parenting-focused mindfulness intervention reduces stress and improves parenting in highly-stressed mothers of adolescents.
  • DOI:
    10.1007/s12671-018-1026-9
  • 发表时间:
    2021-03
  • 期刊:
  • 影响因子:
    3.6
  • 作者:
    Tara M Chaplin;Turpyn CC;Fischer S;Martelli AM;Ross CE;Leichtweis RN;Miller AB;Sinha R
  • 通讯作者:
    Sinha R

Tara M Chaplin的其他文献

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{{ truncateString('Tara M Chaplin', 18)}}的其他基金

Integrating neural and momentary assessment of parenting, arousal, and adolescent substance use
整合对育儿、唤醒和青少年物质使用的神经和瞬时评估
  • 批准号:
    10729938
  • 财政年份:
    2023
  • 资助金额:
    $ 47.32万
  • 项目类别:
Efficacy and Neurobiological Mechanisms of a Parenting-Focused Mindfullness Intervention to Prevent Adolescent Substance Use
以育儿为中心的正念干预预防青少年药物使用的功效和神经生物学机制
  • 批准号:
    10316366
  • 财政年份:
    2021
  • 资助金额:
    $ 47.32万
  • 项目类别:
Efficacy and Neurobiological Mechanisms of a Parenting-Focused Mindfullness Intervention to Prevent Adolescent Substance Use
以育儿为中心的正念干预预防青少年药物使用的功效和神经生物学机制
  • 批准号:
    10447182
  • 财政年份:
    2021
  • 资助金额:
    $ 47.32万
  • 项目类别:
Parent-Adolescent Interactions and Substance Abuse Risk: Gender Differences
父母与青少年的互动和药物滥用风险:性别差异
  • 批准号:
    8704616
  • 财政年份:
    2013
  • 资助金额:
    $ 47.32万
  • 项目类别:
Reducing stress with parenting-focused mindfulness to prevent youth substance use
通过以养育为中心的正念来减轻压力,以防止青少年滥用药物
  • 批准号:
    8668214
  • 财政年份:
    2013
  • 资助金额:
    $ 47.32万
  • 项目类别:
Reducing stress with parenting-focused mindfulness to prevent youth substance use
通过以养育为中心的正念来减轻压力,以防止青少年滥用药物
  • 批准号:
    8634088
  • 财政年份:
    2013
  • 资助金额:
    $ 47.32万
  • 项目类别:
Parent-adolescent interactions and substance abuse risk: Gender differences
父母与青少年的互动和药物滥用风险:性别差异
  • 批准号:
    8543693
  • 财政年份:
    2012
  • 资助金额:
    $ 47.32万
  • 项目类别:
Parent-adolescent interactions and substance abuse risk: Gender differences
父母与青少年的互动和药物滥用风险:性别差异
  • 批准号:
    9113521
  • 财政年份:
    2012
  • 资助金额:
    $ 47.32万
  • 项目类别:
Parent-adolescent interactions and substance abuse risk: Gender differences
父母与青少年的互动和药物滥用风险:性别差异
  • 批准号:
    8397912
  • 财政年份:
    2012
  • 资助金额:
    $ 47.32万
  • 项目类别:
Parent-adolescent interactions, gender, and substance use: Brain mechanisms.
父母与青少年的互动、性别和物质使用:大脑机制。
  • 批准号:
    9922233
  • 财政年份:
    2012
  • 资助金额:
    $ 47.32万
  • 项目类别:

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