Leadership Administrative Core - LAC

性别和年龄在对萨迪（SADII）领导人免疫方面的差异 管理核心摘要 流感免疫力的性别和年龄差异评分（SADII）的主要目标是 系统地评估整个生命过程中疫苗诱导的免疫应答的性别差异， 考虑到激素，基因，年龄和虚弱作为独立和联合介导的作用 因素南部非洲发展倡议第二阶段领导行政核心的主要目标是提供集中的 管理，领导，严谨，共享和传播来自拟议研究项目的数据 和核心在SADII评分。这一目标将通过实现三个具体目标来实现。目标1将是 为所有SADII SCORE研究者提供集中的结构化管理。SADII评分将 物理上被安置在约翰霍普金斯大学分子微生物学和免疫学系（MMI） 霍普金斯布隆伯格公共卫生学院和通过SADII职业提升核心，将 与约翰霍普金斯BIRCWH计划和约翰霍普金斯妇女健康、性、 性别研究（JH-CWHSGR）。目标2是为SADII评分提供科学领导 程序.南部非洲发展第二阶段拉丁美洲和加勒比区域方案将确保所进行的研究严谨， 更大的科学界，指导初级教师新的研究性别作为一个生物变量， 并将SADII评分纳入约翰霍普金斯大学的概念框架和教学中 大学拉丁美洲和加勒比地区可持续发展第二阶段的目标3将设法加强传播可持续发展第二阶段的研究结果 约翰霍普金斯研究界、更广泛的科学界和政府决策的得分 确定流感疫苗株和平台的机构。传播南部非洲发展研究所的研究结果 SCORE将涉及不同的平台，包括但不限于：1）结果的展示和传播 在年度JH-CWHSGR研讨会上，专业协会的国家和国际会议，以及 性别差异研究组织是一个国际研究协会， Sabra Klein博士担任主席（2018-2020）; 2）将性别概念作为生物变量嵌入 纳入约翰霍普金斯研究生和医学院课程; 3）建立严格的出版计划 这将确保来自SADII评分的研究、想法和信息的出版物 适当承认南部非洲发展倡议所作的贡献; 4）为南部非洲发展倡议建立一个信息网站 SCORE链接到约翰霍普金斯内外的其他相关网站;以及5）社交媒体 参与立即传播可持续发展倡议第二阶段的研究、介绍和活动。程序 主任（萨布拉·克莱因博士）和联合主任（帕特里夏·吉尔哈特博士）具有研究专长和领导能力 技能，以确保达到和超过SADII评分的总体目标。

SEX AND AGE DIFFERENCES IN IMMUNITY TO INFLUENZA (SADII) LEADERSHIP ADMINISTRATIVE CORE SUMMARY The primary goal of the SCORE on Sex and Age Differences in Immunity to Influenza (SADII) is to systematically evaluate sex differences in vaccine-induced immune responses across the life course, with consideration of the role that hormones, genes, age, and frailty play as independent and combined mediating factors. The primary objective of the SADII Leadership Administrative Core (LAC) is to provide centralized management, leadership, rigor, sharing, and dissemination of the data from the proposed Research Projects and Cores in the SADII SCORE. This objective will be met by accomplishing three specific aims. Aim 1 will be to provide a centralized, structured administration for all SADII SCORE investigators. The SADII SCORE will be physically housed within the Department of Molecular Microbiology and Immunology (MMI) at the Johns Hopkins Bloomberg School of Public Health and through the SADII Career Enhancement Core, will be integrated with the Johns Hopkins BIRCWH program and the Johns Hopkins Center for Women’s Health, Sex, and Gender Research (JH-CWHSGR). Aim 2 will be to provide scientific leadership for the SADII SCORE program. The SADII LAC will ensure rigor in the research conducted, dissemination of the research results to the greater scientific community, mentoring of junior faculty new to the study of sex as a biological variable, and integration of the SADII SCORE into the conceptual framework and teachings at Johns Hopkins University. Aim 3 of the SADII LAC will seek to enhance dissemination of research findings from the SADII SCORE to the Johns Hopkins research community, broader scientific community, and governmental decision bodies determining influenza vaccine strains and platforms. Dissemination of research findings from the SADII SCORE will involve diverse platforms, including, but not limited to: 1) presentation and dissemination of results at the annual JH-CWHSGR symposium, national and international meetings of professional societies, and the annual meeting of the Organization for the Study of Sex Differences, which is an international research society, for which Dr. Sabra Klein is President (2018-2020); 2) embedding the concept of sex as a biological variable into the Johns Hopkins graduate and medical school curriculum; 3) establishment of a rigorous publication plan that will ensure that publications of research, ideas, and information derived from the SADII SCORE will appropriately acknowledge SADII for its contribution; 4) development of an informational website for the SADII SCORE that links to other related websites both within and outside of Johns Hopkins; and 5) social media engagement for immediate dissemination of SADII research, presentations, and activities. The Program Director (Dr. Sabra Klein) and Co-Director (Dr. Patricia Gearhart) have the research expertise and leadership skills to ensure that the overarching goals of the SADII SCORE are met and exceeded.