Leadership Administrative Core - LAC

流感免疫力 (SADII) 领导力的性别和年龄差异 行政核心概要 流感免疫力性别和年龄差异评分 (SADII) 的主要目标是 系统地评估整个生命过程中疫苗诱导的免疫反应的性别差异， 考虑激素、基因、年龄和虚弱作为独立和联合中介的作用 因素。 SADII 领导行政核心 (LAC) 的主要目标是提供集中化服务 拟议研究项目数据的管理、领导、严谨、共享和传播 以及 SADII SCORE 中的核心。这一目标将通过实现三个具体目标来实现。目标 1 将是 为所有 SADII SCORE 调查员提供集中、结构化的管理。 SADII SCORE 将 物理上位于约翰斯大学分子微生物学和免疫学系 (MMI) 霍普金斯大学彭博公共卫生学院并通过 SADII 职业增强核心，将 与约翰·霍普金斯大学 BIRCWH 计划和约翰·霍普金斯大学妇女健康、性、 和性别研究（JH-CWHSGR）。目标 2 是为 SADII SCORE 提供科学领导 程序。 SADII LAC 将确保所进行的研究的严谨性，并将研究结果传播给 更大的科学界，对刚接触性别作为生物变量研究的初级教师进行指导， 并将 SADII SCORE 纳入约翰·霍普金斯大学的概念框架和教学 大学。 SADII LAC 的目标 3 将寻求加强 SADII 研究成果的传播 为约翰霍普金斯大学研究界、更广泛的科学界和政府决策评分 确定流感疫苗株和平台的机构。传播 SADII 的研究成果 SCORE将涉及多种平台，包括但不限于：1）结果的呈现和传播 在年度 JH-CWHSGR 研讨会、专业协会的国内和国际会议以及 性别差异研究组织（一个国际研究协会）的年会， Sabra Klein 博士担任主席（2018-2020 年）； 2）将性别概念嵌入生物变量 进入约翰·霍普金斯大学研究生和医学院课程； 3）制定严格的出版计划 这将确保源自 SADII SCORE 的研究、想法和信息的出版物 适当承认 SADII 的贡献； 4) 为 SADII 开发信息网站 SCORE 链接到约翰·霍普金斯大学内外的其他相关网站； 5）社交媒体 参与立即传播 SADII 研究、演示和活动。该计划 主任（Sabra Klein 博士）和联合主任（Patricia Gearhart 博士）拥有研究专业知识和领导力 确保达到并超越 SADII SCORE 总体目标的技能。

SEX AND AGE DIFFERENCES IN IMMUNITY TO INFLUENZA (SADII) LEADERSHIP ADMINISTRATIVE CORE SUMMARY The primary goal of the SCORE on Sex and Age Differences in Immunity to Influenza (SADII) is to systematically evaluate sex differences in vaccine-induced immune responses across the life course, with consideration of the role that hormones, genes, age, and frailty play as independent and combined mediating factors. The primary objective of the SADII Leadership Administrative Core (LAC) is to provide centralized management, leadership, rigor, sharing, and dissemination of the data from the proposed Research Projects and Cores in the SADII SCORE. This objective will be met by accomplishing three specific aims. Aim 1 will be to provide a centralized, structured administration for all SADII SCORE investigators. The SADII SCORE will be physically housed within the Department of Molecular Microbiology and Immunology (MMI) at the Johns Hopkins Bloomberg School of Public Health and through the SADII Career Enhancement Core, will be integrated with the Johns Hopkins BIRCWH program and the Johns Hopkins Center for Women’s Health, Sex, and Gender Research (JH-CWHSGR). Aim 2 will be to provide scientific leadership for the SADII SCORE program. The SADII LAC will ensure rigor in the research conducted, dissemination of the research results to the greater scientific community, mentoring of junior faculty new to the study of sex as a biological variable, and integration of the SADII SCORE into the conceptual framework and teachings at Johns Hopkins University. Aim 3 of the SADII LAC will seek to enhance dissemination of research findings from the SADII SCORE to the Johns Hopkins research community, broader scientific community, and governmental decision bodies determining influenza vaccine strains and platforms. Dissemination of research findings from the SADII SCORE will involve diverse platforms, including, but not limited to: 1) presentation and dissemination of results at the annual JH-CWHSGR symposium, national and international meetings of professional societies, and the annual meeting of the Organization for the Study of Sex Differences, which is an international research society, for which Dr. Sabra Klein is President (2018-2020); 2) embedding the concept of sex as a biological variable into the Johns Hopkins graduate and medical school curriculum; 3) establishment of a rigorous publication plan that will ensure that publications of research, ideas, and information derived from the SADII SCORE will appropriately acknowledge SADII for its contribution; 4) development of an informational website for the SADII SCORE that links to other related websites both within and outside of Johns Hopkins; and 5) social media engagement for immediate dissemination of SADII research, presentations, and activities. The Program Director (Dr. Sabra Klein) and Co-Director (Dr. Patricia Gearhart) have the research expertise and leadership skills to ensure that the overarching goals of the SADII SCORE are met and exceeded.