JH-EPICS Administrative Core

JH-EPICS行政核心摘要 约翰霍普金斯大学SARS-CoV-2致病和免疫卓越中心的主要目标是： EPICS)是系统地评估外周血液中对SARS-CoV-2的先天、T细胞和抗体反应 新冠肺炎患者的单个核细胞和血清标本。通过深入分析，JH- EPICS将识别免疫反应和严重新冠肺炎的修饰物，并分离细胞和 新冠肺炎治疗的分子靶点及其与SARS-CoV-2必要保护的相关性 疫苗诱导的免疫力。JH-EPICS管理核心(AC)的主要目标是提供 集中管理、领导、指导、共享和传播计划中的数据 JH-EPICS中的研究项目和核心，以确保能够实现总体研究目标。第一 在Sabra Klein博士和Andrea Cox博士的多重PI领导下，Aim将提供行政和 JH-EPICS的预算管理以及科学领导和沟通。JH-EPICS AC 将分配资金，组织每月研究会议，并确保将JH-EPICS整合到 约翰霍普金斯大学的新冠肺炎研究和教育网络。空调还将制定标准 审查来自生物储存库的标本请求及其分配的操作程序 作为由JH-EPICS生成并经SeroNet批准的数据的收集、处理和共享 督导委员会。JH-EPICS AC的第二个目标将是促进与SeroNet和 其他网络活动。JH-EPICS AC将参与所有跨SeroNet倡议，包括 建立跨SeroNet合作研究项目。最后，JH-EPICS AC的第三个目标将 将加强JH-EPICS研究成果的传播，并制定评估计划。 JH-EPICS研究成果的传播将涉及出版物和成果的传播 SeroNet年度会议、专业协会的国家和国际会议以及月刊 以中心为中心的研究会议。JH-EPICS网站的开发和社交媒体的存在将进一步 协助向更广泛的受众传播研究成果。最后，JH-EPICS AC将建立一个 严格的评估计划，包括年度进度报告、现场考察和要求的文件(例如，SOP) 来自美国国立卫生研究院。目标是确保研究和研究成果的适当管理和有效传播。 将JH-EPICS的数据提供给更广泛的社区，包括通过公众宣传。

JH-EPICS ADMINISTRATIVE CORE SUMMARY The primary goal of the Johns Hopkins Excellence in Pathogenesis and Immunity Center for SARS-CoV-2 (JH- EPICS) is to systematically evaluate innate, T cell, and antibody responses to SARS-CoV-2 in peripheral blood mononuclear cells and serological samples from COVID-19 patients. Through in depth analyses, the JH- EPICS will identify the modifiers of the immune response and severe COVID-19 and isolate the cellular and molecular targets for COVID-19 treatments as well as the correlates of protection necessary for SARS-CoV-2 vaccine-induced immunity. The primary objective of the JH-EPICS Administrative Core (AC) is to provide centralized management, leadership, mentoring, sharing, and dissemination of the data from the proposed Research Projects and Cores in JH-EPICS to ensure that the overarching research goals can be met. The first Aim, under the Multiple PI leadership of Drs. Sabra Klein and Andrea Cox, will be to provide administrative and budgetary management as well as scientific leadership and communication for JH-EPICS. The JH-EPICS AC will distribute funds, organize monthly research meetings, and ensure integration of the JH-EPICS into the COVID-19 research and educational networks at Johns Hopkins University. The AC will also develop standard operating procedures for reviewing requests for specimens from the biorepository and their distribution as well as the collection, processing, and sharing of data generated by the JH-EPICS and approved by the SeroNet Steering Committee. The second Aim of the JH-EPICS AC will be to foster engagement with SeroNet and other network activities. The JH-EPICS AC will participate in all trans-SeroNet initiatives, including establishment of trans-SeroNet collaborative research projects. Finally, the third Aim of the JH-EPICS AC will be to enhance dissemination of research findings from the JH-EPICS and establish an evaluation plan. Dissemination of research findings from the JH-EPICS will involve publications and dissemination of results at the annual SeroNet meeting, national and international meetings of professional societies, and the monthly Center-wise research meetings. Development of a JH-EPICS website and social media presence will further assist with dissemination of research findings to a broader audience. Finally, the JH-EPICS AC will establish a rigorous evaluation plan, including annual progress reports, site visits, and requested documents (e.g., SOPs) from NIH. The goal will be to ensure appropriate management and productive dissemination of research and data from JH-EPICS to the broader community, including through public outreach.