JH-EPICS Administrative Core

JH-EPICS管理核心摘要 约翰霍普金斯SARS-CoV-2发病机制和免疫卓越中心（JH- EPICS）是系统地评估外周血中对SARS-CoV-2的先天性、T细胞和抗体应答 来自COVID-19患者的单核细胞和血清样本。通过深入分析， EPICS将识别免疫反应和严重COVID-19的调节剂，并分离细胞和 COVID-19治疗的分子靶点以及SARS-CoV-2所需保护的相关因素 疫苗诱导免疫JH-EPICS行政核心（AC）的主要目标是提供 集中管理、领导、指导、共享和传播来自拟议 JH-EPICS中的研究项目和核心，以确保能够实现总体研究目标。第一 在Sabra Klein博士和Andrea考克斯博士的领导下，多个PI的目标是提供行政和 预算管理以及JH-EPICS的科学领导和沟通。JH-EPICS AC 将分配资金，组织每月的研究会议，并确保将JH-EPICS整合到 约翰霍普金斯大学的COVID-19研究和教育网络。AC还将制定标准 审查生物储存库标本申请及其分发的操作程序 收集、处理和共享JH-EPICS生成并经SeroNet批准的数据 指导委员会。JH-EPICS AC的第二个目标是促进与SeroNet的合作， 其他网络活动。JH-EPICS AC将参与所有trans-SeroNet倡议，包括 建立跨SeroNet合作研究项目。最后，JH-EPICS AC的第三个目标将 加强JH-EPICS研究结果的传播，并制定评估计划。 JH-EPICS研究结果的传播将涉及出版物和结果的传播， 每年的SeroNet会议，专业协会的国家和国际会议，以及每月的 中心研究会议。JH-EPICS网站和社交媒体的开发将进一步 协助向更广泛的受众传播研究成果。最后，JH-EPICS AC将建立一个 严格的评估计划，包括年度进度报告、现场访问和要求的文件（例如，SOP） 来自NIH。目标是确保适当管理和富有成效地传播研究成果， 将JH-EPICS的数据提供给更广泛的社区，包括通过公共宣传。

JH-EPICS ADMINISTRATIVE CORE SUMMARY The primary goal of the Johns Hopkins Excellence in Pathogenesis and Immunity Center for SARS-CoV-2 (JH- EPICS) is to systematically evaluate innate, T cell, and antibody responses to SARS-CoV-2 in peripheral blood mononuclear cells and serological samples from COVID-19 patients. Through in depth analyses, the JH- EPICS will identify the modifiers of the immune response and severe COVID-19 and isolate the cellular and molecular targets for COVID-19 treatments as well as the correlates of protection necessary for SARS-CoV-2 vaccine-induced immunity. The primary objective of the JH-EPICS Administrative Core (AC) is to provide centralized management, leadership, mentoring, sharing, and dissemination of the data from the proposed Research Projects and Cores in JH-EPICS to ensure that the overarching research goals can be met. The first Aim, under the Multiple PI leadership of Drs. Sabra Klein and Andrea Cox, will be to provide administrative and budgetary management as well as scientific leadership and communication for JH-EPICS. The JH-EPICS AC will distribute funds, organize monthly research meetings, and ensure integration of the JH-EPICS into the COVID-19 research and educational networks at Johns Hopkins University. The AC will also develop standard operating procedures for reviewing requests for specimens from the biorepository and their distribution as well as the collection, processing, and sharing of data generated by the JH-EPICS and approved by the SeroNet Steering Committee. The second Aim of the JH-EPICS AC will be to foster engagement with SeroNet and other network activities. The JH-EPICS AC will participate in all trans-SeroNet initiatives, including establishment of trans-SeroNet collaborative research projects. Finally, the third Aim of the JH-EPICS AC will be to enhance dissemination of research findings from the JH-EPICS and establish an evaluation plan. Dissemination of research findings from the JH-EPICS will involve publications and dissemination of results at the annual SeroNet meeting, national and international meetings of professional societies, and the monthly Center-wise research meetings. Development of a JH-EPICS website and social media presence will further assist with dissemination of research findings to a broader audience. Finally, the JH-EPICS AC will establish a rigorous evaluation plan, including annual progress reports, site visits, and requested documents (e.g., SOPs) from NIH. The goal will be to ensure appropriate management and productive dissemination of research and data from JH-EPICS to the broader community, including through public outreach.