JH-EPICS Administrative Core

JH-EPICS 管理核心

• 批准号: 10688357
• 负责人: SABRA L. KLEIN
• 金额: $ 44.47万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10688357
• 关键词: 2019-nCoV; Antibody Response; COVID-19; COVID-19 patient; COVID-19 treatment; COVID-19 vaccine; Collection; Communication; Communities; Data; Development; Ensure; Evaluation; Fostering; Funding; Goals; Immune response; Immunity; Information Dissemination; International; Leadership; Mentors; Molecular Target; Pathogenesis; Peripheral Blood Mononuclear Cell; Procedures; Professional Organizations; Progress Reports; Publications; Research; Research Personnel; Research Project Grants; Sampling; Serology; Site Visit; Specimen; T-Lymphocyte; United States National Institutes of Health; Universities; biobank; cellular targeting; data dissemination; data sharing; meetings; outreach; severe COVID-19; skills; social media; vaccine-induced immunity; web site

JH-EPICS ADMINISTRATIVE CORE SUMMARY The primary goal of the Johns Hopkins Excellence in Pathogenesis and Immunity Center for SARS-CoV-2 (JH- EPICS) is to systematically evaluate innate, T cell, and antibody responses to SARS-CoV-2 in peripheral blood mononuclear cells and serological samples from COVID-19 patients. Through in depth analyses, the JH- EPICS will identify the modifiers of the immune response and severe COVID-19 and isolate the cellular and molecular targets for COVID-19 treatments as well as the correlates of protection necessary for SARS-CoV-2 vaccine-induced immunity. The primary objective of the JH-EPICS Administrative Core (AC) is to provide centralized management, leadership, mentoring, sharing, and dissemination of the data from the proposed Research Projects and Cores in JH-EPICS to ensure that the overarching research goals can be met. The first Aim, under the Multiple PI leadership of Drs. Sabra Klein and Andrea Cox, will be to provide administrative and budgetary management as well as scientific leadership and communication for JH-EPICS. The JH-EPICS AC will distribute funds, organize monthly research meetings, and ensure integration of the JH-EPICS into the COVID-19 research and educational networks at Johns Hopkins University. The AC will also develop standard operating procedures for reviewing requests for specimens from the biorepository and their distribution as well as the collection, processing, and sharing of data generated by the JH-EPICS and approved by the SeroNet Steering Committee. The second Aim of the JH-EPICS AC will be to foster engagement with SeroNet and other network activities. The JH-EPICS AC will participate in all trans-SeroNet initiatives, including establishment of trans-SeroNet collaborative research projects. Finally, the third Aim of the JH-EPICS AC will be to enhance dissemination of research findings from the JH-EPICS and establish an evaluation plan. Dissemination of research findings from the JH-EPICS will involve publications and dissemination of results at the annual SeroNet meeting, national and international meetings of professional societies, and the monthly Center-wise research meetings. Development of a JH-EPICS website and social media presence will further assist with dissemination of research findings to a broader audience. Finally, the JH-EPICS AC will establish a rigorous evaluation plan, including annual progress reports, site visits, and requested documents (e.g., SOPs) from NIH. The goal will be to ensure appropriate management and productive dissemination of research and data from JH-EPICS to the broader community, including through public outreach.

JH-EPICS 管理核心摘要 约翰·霍普金斯大学 SARS-CoV-2 发病机制和免疫卓越中心 (JH- EPICS）旨在系统地评估外周血中对 SARS-CoV-2 的先天反应、T 细胞和抗体反应 来自 COVID-19 患者的单核细胞和血清学样本。通过深入分析，JH- EPICS 将识别免疫反应和严重 COVID-19 的调节因子，并分离细胞和 COVID-19 治疗的分子靶点以及 SARS-CoV-2 所需保护的相关性 疫苗诱导的免疫。 JH-EPICS 管理核心 (AC) 的主要目标是提供 集中管理、领导、指导、共享和传播拟议的数据 JH-EPICS 中的研究项目和核心确保总体研究目标得以实现。第一个 目标，在 Drs 的多个 PI 领导下。 Sabra Klein 和 Andrea Cox 将提供行政和 JH-EPICS 的预算管理以及科学领导和沟通。 JH-EPICS AC 将分配资金，组织每月的研究会议，并确保 JH-EPICS 纳入 约翰·霍普金斯大学的 COVID-19 研究和教育网络。 AC还将制定标准 审查生物样本库标本申请及其分发的操作程序 作为 JH-EPICS 生成并经 SeroNet 批准的数据的收集、处理和共享 指导委员会。 JH-EPICS AC 的第二个目标是促进与 SeroNet 和 其他网络活动。 JH-EPICS AC 将参与所有跨 SeroNet 计划，包括 建立跨SeroNet合作研究项目。最后，JH-EPICS AC 的第三个目标是 加强JH-EPICS研究成果的传播并制定评估计划。 JH-EPICS 研究成果的传播将涉及在以下网站发表和传播结果： 年度 SeroNet 会议、专业协会的国内和国际会议以及月度会议 中心研究会议。 JH-EPICS 网站和社交媒体的开发将进一步推动 协助将研究成果传播给更广泛的受众。最后，JH-EPICS AC 将建立一个 严格的评估计划，包括年度进度报告、实地考察和所需文件（例如标准操作程序） 来自美国国立卫生研究院。目标是确保研究和成果的适当管理和有效传播 将数据从 JH-EPICS 提供给更广泛的社区，包括通过公共宣传。