Sex and Age Differences in Immunity to Influenza (SADII)

流感免疫力的性别和年龄差异 (SADII)

• 批准号: 10261763
• 负责人: SABRA L. KLEIN
• 金额: $ 3.97万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10261763
• 关键词: Affect; Age; Aging; Animal Model; Antiviral Agents; Award; Centers of Research Excellence; Cessation of life; Clinical; Collaborations; Communicable Diseases; Community Health; Female; Funding; Gender; Genetic; Hormonal; Hospitalization; Human; Immune response; Immunity; Immunology; Influenza; Influenza vaccination; International; Leadership; Life Cycle Stages; Memory; Microbiology; Mission; Parents; Pathogenesis; Policies; Population; Positioning Attribute; Productivity; Public Health; Qualitative Research; Research; Research Personnel; Research Project Grants; Resources; Role; Scientist; Sex Differences; Specialized Center; Statistical Models; Testing; Translational Research; United States; Universities; Vaccine Antigen; Vaccines; Women' s Health; age difference; age related; biological sex; career; development policy; frailty; gender difference; influenza infection; influenza virus vaccine; influenzavirus; novel; programs; response; seasonal influenza; sex; social; translational approach; translational research program; translational scientist; universal influenza vaccine; vaccination outcome; vaccine-induced immunity

Summary of funded parent award: Sex and Age Differences in Immunity to Influenza Despite the availability of antivirals and vaccines, influenza remains a significant public health threat; causing approximately 100,000 hospitalizations, 30,000 deaths, and approximately $7 billion in lost productivity per year in the United States alone. Sex and age are emerging as two host variables that significantly impact the pathogenesis of influenza virus infection and responses to influenza vaccines. The Sex and Age Differences in Immunity to Influenza (SADII, pronounced sādē) Specialized Center of Research Excellence (SCORE) leverages the internationally recognized research, resources, and educational opportunities at Johns Hopkins University to transform women’s health and impact policy decisions about influenza vaccine programs, including universal influenza vaccines. The overarching hypothesis of the SADII SCORE Research Projects is that female-biased, vaccine-induced immunity to influenza viruses is age-dependent and reflects both hormonal, genetic, and social differences between the sexes that impact immune responses (i.e., both effector and memory) to influenza vaccine antigens and outcomes. SADII brings together investigators focused on 1) seasonal influenza vaccination in an existing age and sex stratified human population; 2) animal models that can test hypotheses and mechanisms of action that are inferred from studies in human populations; and 3) the contributions of age, frailty, sex, and gender to vaccine outcomes using statistical models and qualitative research. By using the combined expertise in our research groups, SADII is uniquely positioned to identify the basis behind sex, age, and gender differences in immune responses to influenza vaccination and disseminate those findings to the broader research, clinical, and public health communities. The overarching mission of the SADII SCORE will be achieved through the following Specific Aims: 1) To provide leadership and oversight of the SADII SCORE and collaboration with other entities at Johns Hopkins and elsewhere to develop a translational research program focused on sex and age differences in immunology and infectious diseases; 2) To systematically evaluate sex and gender differences in vaccine-induced immune responses across the life course using translational approaches involving human studies and mechanistic animal models; and 3) To meet the career enhancement needs of diverse translational scientists studying sex differences at Johns Hopkins and beyond. We are prepared to transform women’s health, sex, and gender research into a signature initiative at Johns Hopkins and in the fields of microbiology and immunology.

受资助家长奖摘要：流感免疫力的性别及年龄差异 尽管抗病毒药物和疫苗的可用性，流感仍然是一个重大的公共卫生威胁; 每年约有10万人住院，3万人死亡，生产力损失约70亿美元。 年仅在美国。性别和年龄正在成为两个主机变量，显著影响 流感病毒感染的发病机制和对流感疫苗的应答。性别和年龄差异 流感免疫力（SADII，发音为sādðe）专业卓越研究中心（SCORE） 利用约翰霍普金斯国际公认的研究，资源和教育机会 大学改变妇女的健康和影响有关流感疫苗计划的政策决定， 包括通用流感疫苗。SADII SCORE研究项目的总体假设是 女性偏见，疫苗诱导的流感病毒免疫力是年龄依赖性的，反映了两者 影响免疫反应的两性之间的激素、遗传和社会差异（即，双效应器 和记忆）对流感疫苗抗原和结果的影响。SADII将调查人员聚集在一起，重点是1） 在现有年龄和性别分层的人群中进行季节性流感疫苗接种; 2）动物模型， 可以测试从人群研究中推断的假设和作用机制; 3） 使用统计模型和定性分析， research.通过使用我们研究小组的综合专业知识，SADII处于独特的地位，可以识别 流感疫苗接种和传播的免疫应答的性别、年龄和性别差异背后的基础 将这些发现推广到更广泛的研究、临床和公共卫生界。联合国的首要使命 SADII评分将通过以下具体目标实现：1）领导和监督 SADII评分和与约翰霍普金斯和其他地方的其他实体合作， 翻译研究计划，重点是免疫学和传染病的性别和年龄差异; 2） 系统评价疫苗诱导的免疫应答在整个生命周期中的性别差异 使用涉及人类研究和机械动物模型的转化方法的课程;以及3） 满足约翰研究性别差异的不同翻译科学家的职业发展需求 霍普金斯和其他地方。我们准备将女性健康、性和性别研究转化为一个签名 在约翰霍普金斯和微生物学和免疫学领域的倡议。