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Sex and Age Differences in Immunity to Influenza (SADII)

流感免疫力的性别和年龄差异 (SADII)

基本信息

批准号：
10649070
负责人：
SABRA L. KLEIN
金额：
$ 2.97万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-30 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10649070
关键词：
Address Adult Adverse reactions Affect Age Age-Years Aging Animal Model Antiviral Agents Autoimmune Avian Influenza Biological Biological Aging Cells Centers of Research Excellence Cessation of life Clinical Clinical Trials Collaborations Communicable Diseases Community Health Complex Data Development Disease Disease Outcome Female Gender Genes Genetic Health Hormonal Hospitalization Human Immune Immune response Immunity Immunologics Immunology Infection Inflammation Inflammatory Influenza Influenza vaccination Interdisciplinary Study International Journals Leadership Life Cycle Stages Longevity Mediating Memory Microbiology Mission Pathogenesis Pathology Persons Pharmacotherapy Physicians Population Positioning Attribute Principal Investigator Productivity Public Health Publishing Recommendation Research Research Personnel Research Project Grants Resources Risk Role Scientist Sex Bias Sex Differences Social outcome Societies Specialized Center Statistical Models Testing Time Translational Research United States United States National Institutes of Health Universities Ursidae Family Vaccination Vaccine Antigen Vaccines Women&apos s Health age difference age related biological sex career development policy experience frailty human old age (65+)improved infectious disease treatment influenza infection influenza outbreak influenza virus vaccine influenzavirus male novel outcome prediction pandemic influenza pathogen preclinical study programs response seasonal influenza sex translational approach translational research program translational scientist treatment response trend universal influenza vaccine vaccination outcome vaccine efficacy vaccine-induced immunity young adult

项目摘要

SEX AND AGE DIFFERENCES IN IMMUNITY TO INFLUENZA (SADII) SUMMARY The NIH Office of Research on Women’s Health (ORWH) should support a Specialized Center of Research Excellence (SCORE) on sex differences in influenza immunity because despite having antivirals and vaccines, influenza remains a significant public health threat, causing approximately 100,000 hospitalizations, 30,000 deaths, and approximately $7 billion in lost productivity in the United States, alone. Sex and age are emerging as two host variables that significantly impact the pathogenesis of influenza virus infection and responses to influenza vaccines. The Sex and Age Differences in Immunity to Influenza (SADII, pronounced sādē) SCORE will leverage the internationally recognized research, resources, and educational opportunities at Johns Hopkins University to transform women’s health and impact the development of and policy decisions about influenza vaccine programs, including universal influenza vaccines. The overarching hypothesis being tested through the SADII SCORE Research Projects is that female-biased vaccine-induced immunity to influenza viruses is age-dependent and reflects both hormonal and genetic differences between the sexes that impact immune responses (i.e., both effector and memory) to influenza vaccine antigens. SADII will bring together investigators focused on 1) seasonal influenza vaccination in an existing age and sex stratified human population; 2) animal models that can test hypotheses and mechanisms of action that are inferred from studies in human populations; and 3) the contributions of age, frailty, sex, and gender to vaccine outcomes using quantitative and qualitative statistical models. By using the combined expertise in our research groups, SADII is uniquely positioned to identify the biological basis behind sex and age differences in immune responses to influenza vaccination and disseminate those findings to the broader research, clinical, and public health communities. The overarching mission of the SADII SCORE will be achieved through the following Specific Aims: 1) To provide leadership and oversight of the SADII SCORE and collaboration with other entities at Johns Hopkins and elsewhere to develop a translational research program focused on sex and age differences in immunology and infectious diseases; 2) To systematically evaluate sex differences in vaccine-induced immune responses across the life course using translational approaches involving human studies and mechanistic animal models; and 3) To meet the career enhancement needs of diverse translational scientists studying sex differences at Johns Hopkins and beyond. We are prepared to transform women’s health, sex, and gender research into a signature initiative at Johns Hopkins and in the fields of microbiology and immunology.

流感免疫力的性别和年龄差异 (SADII) 摘要美国国立卫生研究院妇女健康研究办公室 (ORWH) 应支持专门研究中心在流感免疫力的性别差异方面表现出色（得分），因为尽管有抗病毒药物和疫苗，流感仍然是一个重大的公共卫生威胁，导致约 10 万人住院、3 万人住院仅在美国，就造成了约 70 亿美元的死亡和生产力损失。性别和年龄正在显现作为两个宿主变量，显着影响流感病毒感染的发病机制和对流感病毒的反应流感疫苗。流感免疫力的性别和年龄差异（SADII，发音为 sādē）评分将利用约翰斯大学国际公认的研究、资源和教育机会霍普金斯大学致力于改变女性健康并影响相关领域的发展和政策决定流感疫苗计划，包括通用流感疫苗。正在检验的总体假设通过 SADII SCORE 研究项目发现，女性偏向的疫苗诱导的流感免疫力病毒与年龄有关，反映了影响性别的荷尔蒙和遗传差异对流感疫苗抗原的免疫反应（即效应器和记忆）。 SADII 将汇聚研究人员重点关注 1) 在现有年龄和性别分层的人群中接种季节性流感疫苗人口; 2）可以测试从研究中推断的假设和作用机制的动物模型在人群中； 3) 年龄、虚弱、性别和性别对疫苗结果的影响定量和定性统计模型。通过利用我们研究小组的综合专业知识，SADII 具有独特的优势，可以确定免疫反应中性别和年龄差异背后的生物学基础流感疫苗接种并将这些发现传播到更广泛的研究、临床和公共卫生领域社区。 SADII SCORE 的总体使命将通过以下具体措施来实现目标： 1) 领导和监督 SADII SCORE 以及与其他实体的合作约翰·霍普金斯大学和其他机构开发了一个专注于性别和年龄差异的转化研究项目免疫学和传染病； 2) 系统评估疫苗诱导的性别差异使用涉及人体研究的转化方法来研究整个生命过程中的免疫反应机械动物模型； 3）满足不同转化科学家的职业提升需求在约翰·霍普金斯大学及其他大学研究性别差异。我们准备改变女性的健康、性、约翰·霍普金斯大学的一项标志性倡议以及微生物学和性别研究领域免疫学。

项目成果

期刊论文数量（22）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Erratum: Author Correction: Age-associated changes in the impact of sex steroids on influenza vaccine responses in males and females.

勘误：作者更正：性类固醇对男性和女性流感疫苗反应影响的年龄相关变化。

DOI：
10.1038/s41541-019-0130-8
发表时间：
2019
期刊：
NPJ vaccines
影响因子：
9.2
作者：
Potluri,Tanvi;Fink,AshleyL;Sylvia,KristynE;Dhakal,Santosh;Vermillion,MeghanS;VomSteeg,Landon;Deshpande,Sharvari;Narasimhan,Harish;Klein,SabraL
通讯作者：
Klein,SabraL

Estradiol Mediates Greater Germinal Center Responses to Influenza Vaccination in Female than Male Mice.

雌二醇介导雌性小鼠比雄性小鼠生发中心对流感疫苗的更大反应。

DOI：
10.1101/2023.11.27.568847
发表时间：
2023
期刊：
bioRxiv : the preprint server for biology
影响因子：
0
作者：
Dhakal,Santosh;Park,Han-Sol;Seddu,Kumba;Lee,John;Creisher,PatrickS;Davis,KimberlyM;Hernandez,IsabellaR;Maul,RobertW;Klein,SabraL
通讯作者：
Klein,SabraL

Sex Differences in Immunity to Viral Infections.