Sex and Age Differences in Immunity to Influenza (SADII)
流感免疫力的性别和年龄差异 (SADII)
基本信息
- 批准号:10649070
- 负责人:
- 金额:$ 2.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-30 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAdverse reactionsAffectAgeAge-YearsAgingAnimal ModelAntiviral AgentsAutoimmuneAvian InfluenzaBiologicalBiological AgingCellsCenters of Research ExcellenceCessation of lifeClinicalClinical TrialsCollaborationsCommunicable DiseasesCommunity HealthComplexDataDevelopmentDiseaseDisease OutcomeFemaleGenderGenesGeneticHealthHormonalHospitalizationHumanImmuneImmune responseImmunityImmunologicsImmunologyInfectionInflammationInflammatoryInfluenzaInfluenza vaccinationInterdisciplinary StudyInternationalJournalsLeadershipLife Cycle StagesLongevityMediatingMemoryMicrobiologyMissionPathogenesisPathologyPersonsPharmacotherapyPhysiciansPopulationPositioning AttributePrincipal InvestigatorProductivityPublic HealthPublishingRecommendationResearchResearch PersonnelResearch Project GrantsResourcesRiskRoleScientistSex BiasSex DifferencesSocial outcomeSocietiesSpecialized CenterStatistical ModelsTestingTimeTranslational ResearchUnited StatesUnited States National Institutes of HealthUniversitiesUrsidae FamilyVaccinationVaccine AntigenVaccinesWomen&aposs Healthage differenceage relatedbiological sexcareerdevelopment policyexperiencefrailtyhuman old age (65+)improvedinfectious disease treatmentinfluenza infectioninfluenza outbreakinfluenza virus vaccineinfluenzavirusmalenoveloutcome predictionpandemic influenzapathogenpreclinical studyprogramsresponseseasonal influenzasextranslational approachtranslational research programtranslational scientisttreatment responsetrenduniversal influenza vaccinevaccination outcomevaccine efficacyvaccine-induced immunityyoung adult
项目摘要
SEX AND AGE DIFFERENCES IN IMMUNITY TO INFLUENZA (SADII) SUMMARY
The NIH Office of Research on Women’s Health (ORWH) should support a Specialized Center of Research
Excellence (SCORE) on sex differences in influenza immunity because despite having antivirals and vaccines,
influenza remains a significant public health threat, causing approximately 100,000 hospitalizations, 30,000
deaths, and approximately $7 billion in lost productivity in the United States, alone. Sex and age are emerging
as two host variables that significantly impact the pathogenesis of influenza virus infection and responses to
influenza vaccines. The Sex and Age Differences in Immunity to Influenza (SADII, pronounced sādē) SCORE
will leverage the internationally recognized research, resources, and educational opportunities at Johns
Hopkins University to transform women’s health and impact the development of and policy decisions about
influenza vaccine programs, including universal influenza vaccines. The overarching hypothesis being tested
through the SADII SCORE Research Projects is that female-biased vaccine-induced immunity to influenza
viruses is age-dependent and reflects both hormonal and genetic differences between the sexes that impact
immune responses (i.e., both effector and memory) to influenza vaccine antigens. SADII will bring together
investigators focused on 1) seasonal influenza vaccination in an existing age and sex stratified human
population; 2) animal models that can test hypotheses and mechanisms of action that are inferred from studies
in human populations; and 3) the contributions of age, frailty, sex, and gender to vaccine outcomes using
quantitative and qualitative statistical models. By using the combined expertise in our research groups, SADII
is uniquely positioned to identify the biological basis behind sex and age differences in immune responses to
influenza vaccination and disseminate those findings to the broader research, clinical, and public health
communities. The overarching mission of the SADII SCORE will be achieved through the following Specific
Aims: 1) To provide leadership and oversight of the SADII SCORE and collaboration with other entities at
Johns Hopkins and elsewhere to develop a translational research program focused on sex and age differences
in immunology and infectious diseases; 2) To systematically evaluate sex differences in vaccine-induced
immune responses across the life course using translational approaches involving human studies and
mechanistic animal models; and 3) To meet the career enhancement needs of diverse translational scientists
studying sex differences at Johns Hopkins and beyond. We are prepared to transform women’s health, sex,
and gender research into a signature initiative at Johns Hopkins and in the fields of microbiology and
immunology.
性别和年龄在抗沙坦(SADII)免疫方面的差异
美国国立卫生研究院妇女健康研究办公室(ORWH)应该支持一个专门的研究中心
卓越(SCORE)对流感免疫力的性别差异,因为尽管有抗病毒药物和疫苗,
流感仍然是一个重大的公共卫生威胁,造成大约10万人住院,3万人死亡,
死亡,仅在美国就损失了大约70亿美元的生产力。性别和年龄正在显现
作为两个宿主变量,显著影响流感病毒感染的发病机制和对
流感疫苗。流感免疫力的性别和年龄差异(SADII,发音为sād)评分
将利用国际公认的研究,资源和教育机会在约翰
霍普金斯大学改变妇女的健康和影响的发展和政策决定
流感疫苗计划,包括通用流感疫苗。被测试的首要假设
通过SADII SCORE研究项目,
病毒是年龄依赖性的,反映了性别之间的激素和遗传差异,
免疫应答(即,效应物和记忆物)与流感疫苗抗原的结合。SADII将汇集
研究者关注1)现有年龄和性别分层人群的季节性流感疫苗接种
2)动物模型,可以测试从研究中推断的假设和作用机制
在人群中;和3)年龄,虚弱,性别和性别对疫苗结果的贡献,
定量和定性统计模型。通过利用我们研究小组的综合专业知识,
是唯一定位,以确定背后的免疫反应的性别和年龄差异的生物学基础,
流感疫苗接种,并将这些发现传播到更广泛的研究,临床和公共卫生
社区. SADII SCORE的首要使命将通过以下具体内容实现
目的:1)领导和监督SADII SCORE,并与其他实体合作,
约翰霍普金斯和其他地方开发一个转化研究计划,重点是性别和年龄差异
2)系统评价疫苗诱导的免疫学和感染性疾病的性别差异,
使用涉及人类研究的转化方法,
机械动物模型; 3)满足不同转化科学家的职业提升需求
在约翰霍普金斯和其他地方研究性别差异。我们已经准备好改变女性的健康,性,
和性别研究成为约翰霍普金斯和微生物学领域的标志性举措,
免疫学
项目成果
期刊论文数量(22)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Erratum: Author Correction: Age-associated changes in the impact of sex steroids on influenza vaccine responses in males and females.
勘误:作者更正:性类固醇对男性和女性流感疫苗反应影响的年龄相关变化。
- DOI:10.1038/s41541-019-0130-8
- 发表时间:2019
- 期刊:
- 影响因子:9.2
- 作者:Potluri,Tanvi;Fink,AshleyL;Sylvia,KristynE;Dhakal,Santosh;Vermillion,MeghanS;VomSteeg,Landon;Deshpande,Sharvari;Narasimhan,Harish;Klein,SabraL
- 通讯作者:Klein,SabraL
Estradiol Mediates Greater Germinal Center Responses to Influenza Vaccination in Female than Male Mice.
雌二醇介导雌性小鼠比雄性小鼠生发中心对流感疫苗的更大反应。
- DOI:10.1101/2023.11.27.568847
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Dhakal,Santosh;Park,Han-Sol;Seddu,Kumba;Lee,John;Creisher,PatrickS;Davis,KimberlyM;Hernandez,IsabellaR;Maul,RobertW;Klein,SabraL
- 通讯作者:Klein,SabraL
Sex Differences in Immunity to Viral Infections.
- DOI:10.3389/fimmu.2021.720952
- 发表时间:2021
- 期刊:
- 影响因子:7.3
- 作者:Jacobsen H;Klein SL
- 通讯作者:Klein SL
Needs and unmet needs for support services for recently pregnant intimate partner violence survivors in Ethiopia during the COVID-19 pandemic.
- DOI:10.1186/s12889-023-15634-7
- 发表时间:2023-04-20
- 期刊:
- 影响因子:4.5
- 作者:
- 通讯作者:
The intersection of biological sex and gender in adverse events following seasonal influenza vaccination in older adults.
- DOI:10.1186/s12979-023-00367-3
- 发表时间:2023-08-29
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
SABRA L. KLEIN其他文献
SABRA L. KLEIN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('SABRA L. KLEIN', 18)}}的其他基金
2023 Sex Differences in Immunity Gordon Research Conference
2023 年免疫性别差异戈登研究会议
- 批准号:
10721480 - 财政年份:2023
- 资助金额:
$ 2.97万 - 项目类别:
Project 3: Defining the antibody landscape after SARS-CoV-2 infection
项目 3:定义 SARS-CoV-2 感染后的抗体格局
- 批准号:
10221910 - 财政年份:2020
- 资助金额:
$ 2.97万 - 项目类别:
Project 3: Defining the antibody landscape after SARS-CoV-2 infection
项目 3:定义 SARS-CoV-2 感染后的抗体格局
- 批准号:
10688368 - 财政年份:2020
- 资助金额:
$ 2.97万 - 项目类别:
Sex and Age Differences in Immunity to Influenza (SADII)
流感免疫力的性别和年龄差异 (SADII)
- 批准号:
10213168 - 财政年份:2018
- 资助金额:
$ 2.97万 - 项目类别:
Genetic and hormonal mechanisms of sex differences in immune responses and influenza vaccine efficacy in young and aged mice
年轻和老年小鼠免疫反应和流感疫苗功效性别差异的遗传和激素机制
- 批准号:
10213173 - 财政年份:2018
- 资助金额:
$ 2.97万 - 项目类别:
Sex and Age Differences in Immunity to Influenza (SADII)
流感免疫力的性别和年龄差异 (SADII)
- 批准号:
10261763 - 财政年份:2018
- 资助金额:
$ 2.97万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 2.97万 - 项目类别:
Research Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 2.97万 - 项目类别:
Standard Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 2.97万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 2.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 2.97万 - 项目类别:
Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 2.97万 - 项目类别:
Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
- 批准号:
10065645 - 财政年份:2023
- 资助金额:
$ 2.97万 - 项目类别:
Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 2.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 2.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 2.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)