Sex and Age Differences in Immunity to Influenza (SADII)

流感免疫力的性别和年龄差异 (SADII)

• 批准号: 10649070
• 负责人: SABRA L. KLEIN
• 金额: $ 2.97万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10649070
• 关键词: Address; Adult; Adverse reactions; Affect; Age; Age-Years; Aging; Animal Model; Antiviral Agents; Autoimmune; Avian Influenza; Biological; Biological Aging; Cells; Centers of Research Excellence; Cessation of life; Clinical; Clinical Trials; Collaborations; Communicable Diseases; Community Health; Complex; Data; Development; Disease; Disease Outcome; Female; Gender; Genes; Genetic; Health; Hormonal; Hospitalization; Human; Immune; Immune response; Immunity; Immunologics; Immunology; Infection; Inflammation; Inflammatory; Influenza; Influenza vaccination; Interdisciplinary Study; International; Journals; Leadership; Life Cycle Stages; Longevity; Mediating; Memory; Microbiology; Mission; Pathogenesis; Pathology; Persons; Pharmacotherapy; Physicians; Population; Positioning Attribute; Principal Investigator; Productivity; Public Health; Publishing; Recommendation; Research; Research Personnel; Research Project Grants; Resources; Risk; Role; Scientist; Sex Bias; Sex Differences; Social outcome; Societies; Specialized Center; Statistical Models; Testing; Time; Translational Research; United States; United States National Institutes of Health; Universities; Ursidae Family; Vaccination; Vaccine Antigen; Vaccines; Women' s Health; age difference; age related; biological sex; career; development policy; experience; frailty; human old age (65+); improved; infectious disease treatment; influenza infection; influenza outbreak; influenza virus vaccine; influenzavirus; male; novel; outcome prediction; pandemic influenza; pathogen; preclinical study; programs; response; seasonal influenza; sex; translational approach; translational research program; translational scientist; treatment response; trend; universal influenza vaccine; vaccination outcome; vaccine efficacy; vaccine-induced immunity; young adult

SEX AND AGE DIFFERENCES IN IMMUNITY TO INFLUENZA (SADII) SUMMARY The NIH Office of Research on Women’s Health (ORWH) should support a Specialized Center of Research Excellence (SCORE) on sex differences in influenza immunity because despite having antivirals and vaccines, influenza remains a significant public health threat, causing approximately 100,000 hospitalizations, 30,000 deaths, and approximately $7 billion in lost productivity in the United States, alone. Sex and age are emerging as two host variables that significantly impact the pathogenesis of influenza virus infection and responses to influenza vaccines. The Sex and Age Differences in Immunity to Influenza (SADII, pronounced sādē) SCORE will leverage the internationally recognized research, resources, and educational opportunities at Johns Hopkins University to transform women’s health and impact the development of and policy decisions about influenza vaccine programs, including universal influenza vaccines. The overarching hypothesis being tested through the SADII SCORE Research Projects is that female-biased vaccine-induced immunity to influenza viruses is age-dependent and reflects both hormonal and genetic differences between the sexes that impact immune responses (i.e., both effector and memory) to influenza vaccine antigens. SADII will bring together investigators focused on 1) seasonal influenza vaccination in an existing age and sex stratified human population; 2) animal models that can test hypotheses and mechanisms of action that are inferred from studies in human populations; and 3) the contributions of age, frailty, sex, and gender to vaccine outcomes using quantitative and qualitative statistical models. By using the combined expertise in our research groups, SADII is uniquely positioned to identify the biological basis behind sex and age differences in immune responses to influenza vaccination and disseminate those findings to the broader research, clinical, and public health communities. The overarching mission of the SADII SCORE will be achieved through the following Specific Aims: 1) To provide leadership and oversight of the SADII SCORE and collaboration with other entities at Johns Hopkins and elsewhere to develop a translational research program focused on sex and age differences in immunology and infectious diseases; 2) To systematically evaluate sex differences in vaccine-induced immune responses across the life course using translational approaches involving human studies and mechanistic animal models; and 3) To meet the career enhancement needs of diverse translational scientists studying sex differences at Johns Hopkins and beyond. We are prepared to transform women’s health, sex, and gender research into a signature initiative at Johns Hopkins and in the fields of microbiology and immunology.

性别和年龄在抗沙坦（SADII）免疫方面的差异 美国国立卫生研究院妇女健康研究办公室（ORWH）应该支持一个专门的研究中心 卓越（SCORE）对流感免疫力的性别差异，因为尽管有抗病毒药物和疫苗， 流感仍然是一个重大的公共卫生威胁，造成大约10万人住院，3万人死亡， 死亡，仅在美国就损失了大约70亿美元的生产力。性别和年龄正在显现 作为两个宿主变量，显著影响流感病毒感染的发病机制和对 流感疫苗。流感免疫力的性别和年龄差异（SADII，发音为sād）评分 将利用国际公认的研究，资源和教育机会在约翰 霍普金斯大学改变妇女的健康和影响的发展和政策决定 流感疫苗计划，包括通用流感疫苗。被测试的首要假设 通过SADII SCORE研究项目， 病毒具有年龄依赖性，反映了性别之间的激素和遗传差异，从而影响 免疫应答（即，效应物和记忆物）与流感疫苗抗原的结合。SADII将汇集 研究者关注1）现有年龄和性别分层人群的季节性流感疫苗接种 群体; 2）可以测试从研究中推断的假设和作用机制的动物模型 在人群中;和3）年龄，虚弱，性别和性别对疫苗结果的贡献， 定量和定性统计模型。通过利用我们研究小组的综合专业知识， 是唯一定位，以确定背后的免疫反应的性别和年龄差异的生物学基础， 流感疫苗接种，并将这些发现传播到更广泛的研究，临床和公共卫生 社区. SADII SCORE的首要使命将通过以下具体内容实现 目的：1）领导和监督SADII SCORE，并与其他实体合作， 约翰霍普金斯和其他地方开发一个转化研究计划，重点是性别和年龄差异 2）系统评价疫苗诱导的免疫学和感染性疾病的性别差异， 使用涉及人类研究的转化方法， 机械动物模型; 3）满足不同转化科学家的职业提升需求 在约翰霍普金斯和其他地方研究性别差异。我们已经准备好改变女性的健康，性， 和性别研究成为约翰霍普金斯和微生物学领域的标志性举措， 免疫学

项目成果

Erratum: Author Correction: Age-associated changes in the impact of sex steroids on influenza vaccine responses in males and females.

勘误：作者更正：性类固醇对男性和女性流感疫苗反应影响的年龄相关变化。

• DOI: 10.1038/s41541-019-0130-8
• 发表时间: 2019
• 期刊: NPJ vaccines
• 影响因子: 9.2
• 作者: Potluri,Tanvi;Fink,AshleyL;Sylvia,KristynE;Dhakal,Santosh;Vermillion,MeghanS;VomSteeg,Landon;Deshpande,Sharvari;Narasimhan,Harish;Klein,SabraL
• 通讯作者: Klein,SabraL

Estradiol Mediates Greater Germinal Center Responses to Influenza Vaccination in Female than Male Mice.

雌二醇介导雌性小鼠比雄性小鼠生发中心对流感疫苗的更大反应。

• DOI: 10.1101/2023.11.27.568847
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Dhakal,Santosh;Park,Han-Sol;Seddu,Kumba;Lee,John;Creisher,PatrickS;Davis,KimberlyM;Hernandez,IsabellaR;Maul,RobertW;Klein,SabraL
• 通讯作者: Klein,SabraL

Sex Differences in Immunity to Viral Infections.

• DOI: 10.3389/fimmu.2021.720952
• 发表时间: 2021
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Jacobsen H;Klein SL
• 通讯作者: Klein SL

Needs and unmet needs for support services for recently pregnant intimate partner violence survivors in Ethiopia during the COVID-19 pandemic.

• DOI: 10.1186/s12889-023-15634-7
• 发表时间: 2023-04-20
• 期刊: BMC public health
• 影响因子: 4.5

The intersection of biological sex and gender in adverse events following seasonal influenza vaccination in older adults.

• DOI: 10.1186/s12979-023-00367-3
• 发表时间: 2023-08-29
• 期刊: Immunity & ageing : I & A