Training in Neurodegenerative Diseases

神经退行性疾病培训

• 批准号: 10213144
• 负责人: Xiongwei Zhu
• 金额: $ 14.69万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10213144
• 关键词: Neurodegenerative Disorders; Training

As our population ages, the incidence of Alzheimer disease (AD), Parkinson disease (PD), Amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases continues to rise, and the need for successful translational research programs is imperative to maintain a healthy aging population and reduce the burden of increased health care costs on society. While much understanding of neurodegenerative mechanisms have been gained over the years of investigation, not much had been successfully translated into patient treatment which calls for deeper appreciation of these diseases through clinical perspective in the future neurodegeneration investigators. The Neurodegeneration Training Program (NTP) has been designed for selected students to provide rigorous pre-doctoral scientific training in the field of neurodegeneration along with extensive clinical exposure. The goal of the NTP is to provide trainees with the fundamental skills necessary for outstanding careers in neurodegeneration research, together with an appreciation of the challenges and complexity of diagnosing and treating neurodegenerative diseases in the clinical setting. The NTP emphasizes rigorous PHD training in fundamental aspects of neurodegeneration and mechanisms of diseases involving neurodegeneration and clinical perspectives through classroom teaching, neurodegeneration-related laboratory research and mentored neurodegenerative clinical experiences combined with educational forums that address important topics in clinical and translational neurodegeneration research. A competitive pool of trainees will combine with 19 outstanding faculty in state-of –the-art facilities to investigate a wide range of neurodegeneration-related topics spanning research areas such as molecular genetics, protein structure, cell and molecular biology and in vitro and in vivo models of disease. The NTP promotes collaboration between departments and schools at Case Western Reserve University, particularly the School of Medicine, and with its affiliated institutions in the Cleveland area: University Hospitals Cleveland Medical Center (UHCMC), and the Cleveland Clinic Foundation (CCF, including the Lerner Research Institute). All of these institutions are within walking distance of each other and this rich training environment enjoys very active basic science and clinical activities. The updated curriculum provides a solid foundation for neurodegeneration research. The well-received mentored neurodegenerative clinical experience has been expanded to include six renowned clinicians enabling direct interaction with patients and caregivers in several different clinical centers close to CWRU campus providing motivation to the trainees to produce advances in disease diagnosis and therapies. The recently added career development and professional enrichment module ensures better preparedness of our trainees to achieve their desired career goals. Together, NTP training will provide trainees a solid foundation for an outstanding neurodegeneration-related career.

随着我国人口的老龄化，阿尔茨海默病（AD）、帕金森病（PD）、肌萎缩侧索硬化症（ALS） 硬化症（ALS）和其他相关的神经退行性疾病的发病率持续上升，并且需要成功的治疗。 转化研究计划对于保持健康的老龄化人口和减轻 增加了社会的医疗费用。虽然对神经退行性机制的了解很多， 虽然经过多年的研究取得了一些成果，但并没有多少成功地转化为病人的治疗。 这就要求将来通过临床视角对这些疾病进行更深入的了解 神经变性研究者神经退行性疾病训练计划（NTP）旨在 选择学生提供严格的博士前科学培训，在神经退行性疾病领域沿着 广泛的临床暴露。NTP的目标是为学员提供必要的基本技能 在神经退行性疾病研究方面的杰出职业生涯，以及对挑战和 在临床环境中诊断和治疗神经退行性疾病的复杂性。NTP强调 严格的博士培训，在神经变性的基本方面和疾病的机制，包括 神经退行性变和临床观点，通过课堂教学，神经退行性变相关 实验室研究和指导神经退行性疾病的临床经验与教育论坛相结合 它涉及临床和转化神经变性研究的重要课题。 一个有竞争力的受训人员库将与19名优秀教师在最先进的设施中联合收割机相结合， 研究范围广泛的神经退行性变相关主题，跨越研究领域，如分子 遗传学、蛋白质结构、细胞和分子生物学以及体外和体内疾病模型。的NTP 促进凯斯西储大学各部门和学校之间的合作，特别是 医学院及其在克利夫兰地区的附属机构：克利夫兰大学医院 医学中心（UHCMC）和克利夫兰诊所基金会（CCF，包括勒纳研究所）。 所有这些机构都在步行距离之内，这种丰富的培训环境非常享受 积极开展基础科学和临床活动。更新的课程为以下方面提供了坚实的基础： 神经退化研究广受欢迎的指导神经退行性疾病的临床经验， 扩大到包括六名著名的临床医生，使患者和护理人员能够在几个 靠近CWRU校园的不同临床中心为学员提供动力，使其在以下方面取得进步： 疾病诊断和治疗。最近增加的职业发展和专业充实模块 确保我们的学员更好地准备实现他们的理想职业目标。NTP培训将 为学员提供一个坚实的基础，一个出色的神经退行性疾病相关的职业生涯。