NRSA Training Core

NRSA 培训核心

• 批准号: 10398854
• 负责人: Thomas Michel
• 金额: $ 72.4万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10398854
• 关键词: Active Learning; Basic Science; Bioinformatics; Biological; Biological Sciences; Biology; Biomedical Research; Boston; Chemicals; Chemistry; Clinical; Clinical Medicine; Clinical Sciences; Communities; Complement; Diagnosis; Discipline; Disease; Doctor of Philosophy; Educational Curriculum; Faculty; Foundations; Funding; Future; Goals; Human Biology; Immunology; Infrastructure; Leadership; Mentors; Methodology; Methods; National Research Service Awards; Neurosciences; Patients; Physicians; Prevention; Research; Science; Students; Systems Biology; TNFSF15 gene; Time; Training; Training Programs; Training Support; Translational Research; Translations; Universities; Workforce Development; base; career; catalyst; experience; graduate student; human disease; learning strategy; programs; translational medicine

The Harvard Catalyst (HC) TL1 Training Program provides the organizational, curricular, and intellectual infrastructure for creating and mentoring a community of students and faculty engaged in disease-oriented research and the translation of principles of human biology to clinical medicine. TL1 offers an interdisciplinary PhD program that integrates human biology and translational medicine training for graduate students in life sciences graduate programs across Harvard University (HU). For the past nine years, the TL1 Program has provided a cornerstone of support for some of the best graduate students in the Leder Human Biology Program (LHB Program). TL1 currently supports 39 students, integrated in the larger community of 78 students in the LHB program. Students in the TL1 program come from graduate programs across Harvard University, including Biological and Biomedical Sciences, Neurosciences, Immunology, Systems Biology, and Chemistry and Chemical Biology. The two TL1 Co-Leads, Connie Cepko, PhD, and Thomas Michel, MD, PhD, have extensive and complementary expertise in basic, translational, and clinical science, and longstanding experience in the leadership of graduate training programs. Going forward, TL1 will continue to represent a key component of the HC Translational Workforce Development (see Core D. Translational Endeavors). TL1 will expand to incorporate new training programs in team science, quantitative methods, and bioinformatics that complement current programs to prepare an effective biomedical research workforce of the future. Each year TL1 will select seven new first-year graduate students. The average time to obtaining the PhD degree for TL1 students is 5.7 years. Awardees will be supported for the first two years of their PhD studies, after which support will come from their PhD mentors' research program, or from institutional funds or foundations. The objectives of the TL1 Training Core are to: (Aim 1) Provide a graduate curriculum with a focus on quantitative team-based active learning methods that will train graduate students in the mechanisms and methodologies of human biology and disease-oriented T0/T1 discovery, and provide them with direct clinical contact with patients and physicians; (Aim 2) Establish a context for human disease-oriented translational research in paracurricular activities across HC that connect clinical medicine with student research in human biology and translational medicine; and (Aim 3) Nurture a diverse community of students and faculty with shared goals of applying rigorous methodologies to the translation of basic discoveries to prevention, diagnosis, and treatment of human disease, while also reaching out into the broader Boston community. TL1 will select and support the training of the best graduate students committed to careers in human biology and translational medicine, and who will benefit from and contribute to the discipline at HU and beyond.

哈佛催化剂（HC）TL 1培训计划提供组织，课程和知识 建立和指导学生和教师社区的基础设施， 研究和人类生物学的原则，临床医学的翻译。TL 1提供跨学科的 博士课程，整合人类生物学和转化医学培训的研究生在生活中 哈佛大学（HU）的科学研究生课程。在过去的九年里，TL 1计划 为Leder人类生物学计划中一些最优秀的研究生提供了支持的基石 (LHB程序）。TL 1目前支持39名学生，融入78名学生的更大社区， LHB程序。TL 1项目的学生来自哈佛大学的研究生课程， 包括生物和生物医学科学、神经科学、免疫学、系统生物学和化学 和化学生物学。两位TL 1联合负责人Connie Cepko博士和托马斯米歇尔医学博士， 在基础、转化和临床科学方面的广泛和互补的专业知识， 领导研究生培训项目的经验。 今后，TL 1将继续成为HC翻译团队的重要组成部分 发展（见核心D。翻译努力）。TL 1将扩展，以纳入新的培训计划， 团队科学，定量方法和生物信息学，补充当前的计划，以准备一个 未来的生物医学研究人才。每年TL 1将选择七个新的一年级毕业生 学生TL 1学生获得博士学位的平均时间为5.7年。获奖者将 支持他们的博士研究的前两年，之后的支持将来自他们的博士导师 研究计划，或从机构基金或基金会。 TL 1培训核心的目标是：（目标1）提供一个研究生课程，重点是 量化的团队为基础的主动学习方法，将培养研究生的机制， 人类生物学和疾病导向的T0/T1发现的方法，并为他们提供直接的临床 与患者和医生接触;（目的2）建立一个以人类疾病为导向的翻译环境 研究跨HC的课外活动，将临床医学与学生的人类研究联系起来 生物学和转化医学;以及（目标3）培养学生和教师的多元化社区， 采用严格的方法将基本发现转化为预防措施的共同目标， 诊断和治疗人类疾病，同时也深入到更广泛的波士顿社区。 TL 1将选择并支持致力于人类生物学职业的最佳研究生的培训 和转化医学，谁将受益于并有助于在胡和超越学科。