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Neural Circuit Mechanisms Mediating TMS and Oxytocin Effects on Social Cognition

介导 TMS 和催产素对社会认知影响的神经回路机制

基本信息

批准号：
10401957
负责人：
MICHAEL L PLATT
金额：
$ 75.38万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-05-05 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10401957
关键词：
Aggressive behavior Ally Animals Anterior Area Argipressin Attention Automation Behavior Behavioral Biological Brain Brain imaging Chiroptera Cognitive Collaborations Communication Computer Vision Systems Computers Coupled Coupling Data Data Science Direct Costs Disease Dorsal Drug Delivery Systems Eating Economics Emotional Emotions Empathy Ethology Evaluation Facial Expression Faculty Feedback Female Future Game Theory Gestures Goals Grant Grooming Health Human Impairment Implant Individual Infusion procedures Investments Knowledge Laboratories Learning Link Macaca Mathematics Medial Mediating Memory Methods Modeling Monkeys Motivation Neurons Noise Oxytocin Peptides Perception Peripheral Personal Satisfaction Pharmacology Physiological Processes Primates Process Psyche structure Publishing Research Resources Same-sex Schizophrenia Schools Shapes Signal Transduction Social Behavior Social Development Social Environment Social Functioning Social Interaction Social support Structure of superior temporal sulcus System Techniques Technology Testing Translating Trust Update Work autism spectrum disorder base cingulate cortex contagion drinking electrical microstimulation evidence base experimental study feeding fighting frontal lobe human-in-the-loop imaging study improved indexing innovation male microstimulation multi-electrode arrays neural circuit neurophysiology neurotransmission relating to nervous system sex social social attention social cognition social group social neuroscience social relationships success wireless

项目摘要

We are requesting an increase in the yearly direct costs to support the aims of the MERIT renewal. What we propose is a dramatic leap into the future of social neuroscience and lies at the bleeding edge of current technology. The proposed research is innovative, ambitious, and necessary for understanding how primate, and by extension human, brains enable appropriate social behavior in the real world. Our proposal advances understanding of how primate brains generate appropriate social behavior through a tightly-integrated, ambitious set of 4 specific aims combining simultaneous wireless neurophysiological recordings in multiple freely-moving monkeys interacting naturally in varied social contexts, semi-to-fully-automated quantification of social behavior using computer vision, pharmacological manipulations, and reversible perturbations of neural activity. To our knowledge, none of these experiments has ever been attempted in macaques. Our pilot data compellingly demonstrate that we can do it.

我们要求增加每年的直接成本，以支持 MERIT 更新的目标。我们什么提出的是社会神经科学未来的巨大飞跃，处于当前社会神经科学的最前沿技术。拟议的研究具有创新性、雄心勃勃，对于了解灵长类动物和通过扩展人类，大脑可以在现实世界中实现适当的社会行为。我们的提案取得进展了解灵长类动物的大脑如何通过紧密整合的、雄心勃勃的大脑产生适当的社会行为一组 4 个具体目标，结合多个自由移动的同时无线神经生理学记录猴子在不同的社会环境中自然互动，社会行为的半自动量化使用计算机视觉、药理学操作和神经活动的可逆扰动。致我们的据了解，这些实验都没有在猕猴身上进行过。我们的试点数据引人注目证明我们可以做到。