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Neural Circuit Mechanisms Mediating TMS and Oxytocin Effects on Social Cognition

介导 TMS 和催产素对社会认知影响的神经回路机制

基本信息

批准号：
10295974
负责人：
MICHAEL L PLATT
金额：
$ 76.87万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-05-05 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10295974
关键词：
Aggressive behavior Ally Animals Anterior Area Argipressin Attention Automation Behavior Behavioral Biological Brain Brain imaging Chiroptera Cognitive Collaborations Communication Computer Vision Systems Computers Coupled Coupling Data Data Science Direct Costs Disease Dorsal Drug Delivery Systems Eating Economics Emotional Emotions Empathy Ethology Evaluation Facial Expression Faculty Feedback Female Future Game Theory Gestures Goals Grant Grooming Health Human Impairment Implant Individual Infusion procedures Investments Knowledge Laboratories Learning Link Macaca Mathematics Medial Mediating Memory Methods Modeling Monkeys Motivation Neurons Noise Oxytocin Peptides Perception Peripheral Personal Satisfaction Pharmacology Physiological Processes Primates Process Psyche structure Publishing Research Resources Same-sex Schizophrenia Schools Shapes Signal Transduction Social Behavior Social Development Social Environment Social Functioning Social Interaction Social support Structure of superior temporal sulcus System Techniques Technology Testing Translating Trust Update Wireless Technology Work autism spectrum disorder base cingulate cortex contagion drinking electrical microstimulation evidence base experimental study feeding fighting frontal lobe human-in-the-loop imaging study improved indexing innovation male microstimulation multi-electrode arrays neural circuit neurophysiology neurotransmission relating to nervous system sex social social attention social cognition social group social neuroscience social relationships success

项目摘要

We are requesting an increase in the yearly direct costs to support the aims of the MERIT renewal. What we propose is a dramatic leap into the future of social neuroscience and lies at the bleeding edge of current technology. The proposed research is innovative, ambitious, and necessary for understanding how primate, and by extension human, brains enable appropriate social behavior in the real world. Our proposal advances understanding of how primate brains generate appropriate social behavior through a tightly-integrated, ambitious set of 4 specific aims combining simultaneous wireless neurophysiological recordings in multiple freely-moving monkeys interacting naturally in varied social contexts, semi-to-fully-automated quantification of social behavior using computer vision, pharmacological manipulations, and reversible perturbations of neural activity. To our knowledge, none of these experiments has ever been attempted in macaques. Our pilot data compellingly demonstrate that we can do it.

我们要求增加每年的直接费用，以支持功绩更新的目标。我们要做的是求婚是迈向社会神经科学未来的一次戏剧性飞跃，它处于当前技术这项拟议的研究是创新的、雄心勃勃的，对于了解灵长类动物是如何推而广之，人类的大脑使现实世界中的适当社交行为成为可能。我们的提案推进了理解灵长类大脑如何通过紧密整合的、雄心勃勃的一套4个特定目标组合在多个自由移动中同时进行无线神经生理记录猴子在不同的社交环境中自然互动，半自动或全自动地量化社交行为使用计算机视觉、药理学操作和神经活动的可逆扰动。致我们的据了解，这些实验从来没有在猕猴身上尝试过。我们的飞行员数据令人信服证明我们能做到。