Neural Circuit Mechanisms Mediating TMS and Oxytocin Effects on Social Cognition

介导 TMS 和催产素对社会认知影响的神经回路机制

基本信息

批准号：
10576968
负责人：
MICHAEL L PLATT
金额：
$ 74.03万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-05-05 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10576968
关键词：
Aggressive behavior Ally Animals Anterior Area Argipressin Attention Automation Behavior Behavioral Biological Brain Brain imaging Chiroptera Cognitive Collaborations Communication Computer Vision Systems Computers Cortical Synchronization Coupled Coupling Data Data Science Direct Costs Disease Dorsal Drug Delivery Systems Eating Economics Emotional Emotions Empathy Ethology Evaluation Facial Expression Faculty Feedback Female Future Game Theory Gestures Goals Grant Grooming Health Heart Rate Homologous Gene Human Impairment Implant Individual Infusion procedures Investments Knowledge Laboratories Learning Link Macaca Mathematics Medial Mediating Memory Methods Modeling Monkeys Motivation Neurons Noise Oxytocin Peptides Perception Peripheral Personal Satisfaction Pharmacology Physiological Processes Primates Process Publishing Research Resources Same-sex Schizophrenia Schools Shapes Signal Transduction Social Behavior Social Development Social Environment Social Functioning Social Interaction Structure of superior temporal sulcus System Techniques Technology Testing Translating Trust Update Work autism spectrum disorder cingulate cortex contagion drinking electrical microstimulation evidence base experimental study feeding fighting frontal lobe human-in-the-loop imaging study improved indexing innovation male mentalization microstimulation multi-electrode arrays neural neural circuit neurophysiology neurotransmission pharmacologic restraint sex social social attention social cognition social group social neuroscience social relationships success wireless

项目摘要

We are requesting an increase in the yearly direct costs to support the aims of the MERIT renewal. What we propose is a dramatic leap into the future of social neuroscience and lies at the bleeding edge of current technology. The proposed research is innovative, ambitious, and necessary for understanding how primate, and by extension human, brains enable appropriate social behavior in the real world. Our proposal advances understanding of how primate brains generate appropriate social behavior through a tightly-integrated, ambitious set of 4 specific aims combining simultaneous wireless neurophysiological recordings in multiple freely-moving monkeys interacting naturally in varied social contexts, semi-to-fully-automated quantification of social behavior using computer vision, pharmacological manipulations, and reversible perturbations of neural activity. To our knowledge, none of these experiments has ever been attempted in macaques. Our pilot data compellingly demonstrate that we can do it.

我们要求增加年度直接成本，以支持绩效续约的目标。我们什么提议是社会神经科学的未来的一个巨大飞跃，并且在当前的出血边缘技术。拟议的研究是创新的，雄心勃勃的，并且是了解灵长类动物和如何通过扩展，大脑可以在现实世界中实现适当的社会行为。我们的建议进展了解灵长类动物大脑如何通过紧密融合，雄心勃勃的人产生适当的社会行为组合4个特定目的，结合了多个自由移动的同时无线神经生理记录猴子在各种社会环境中自然互动，半自动化的社会行为量化使用计算机视觉，药理学操纵以及神经活动的可逆扰动。向我们知识，这些实验从未尝试过猕猴。我们的飞行员数据令人震惊证明我们可以做到。