Immune Mechanisms Underlying the Neuroprotective Effects of Physical Activity in Human and Mouse Models of Genetic Risk for Alzheimers Disease

在阿尔茨海默病遗传风险的人类和小鼠模型中，体力活动的神经保护作用背后的免疫机制

• 批准号: 10321974
• 负责人: Bruce T Lamb
• 金额: $ 41万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10321974
• 关键词: Alzheimer' s Disease; Alzheimer' s disease risk; Amyloid deposition; Anatomy; Animals; Biochemical; Brain; Cerebrum; Diffusion Magnetic Resonance Imaging; Elderly; Genetic Risk; Hippocampus (Brain); Histologic; Image; Immune; Individual; MRI Scans; Magnetic Resonance Imaging; Measures; Mus; Outcome; Physical activity; Positron-Emission Tomography; Risk; Scanning; Spin Labels; Testing; anatomic imaging; apolipoprotein E-4; blood perfusion; design; human model; human study; human subject; longitudinal design; mouse model

项目成果

Physical activity and brain function in older adults at increased risk for Alzheimer's disease.

• DOI: 10.3390/brainsci3010054
• 发表时间: 2013-01-14
• 期刊: Brain sciences
• 影响因子: 3.3
• 作者: Smith JC;Nielson KA;Woodard JL;Seidenberg M;Rao SM
• 通讯作者: Rao SM

Introduction to JINS Special Issue on Human Brain Connectivity in the Modern Era: Relevance to Understanding Health and Disease.

• DOI: 10.1017/s1355617716000047
• 发表时间: 2016-02
• 期刊: Journal of the International Neuropsychological Society : JINS
• 作者: Barch DM;Verfaellie M;Rao SM
• 通讯作者: Rao SM

Introduction to the JINS Special Issue: Physical Activity and Brain Plasticity.

JINS 特刊简介：体力活动与大脑可塑性。

• DOI: 10.1017/s1355617715001149
• 发表时间: 2015
• 期刊: Journal of the International Neuropsychological Society : JINS
• 作者: CarsonSmith,J;Erickson,KirkI;Rao,StephenM
• 通讯作者: Rao,StephenM

Performance variability during a multitrial list-learning task as a predictor of future cognitive decline in healthy elders.

多试验列表学习任务中的表现变异性可作为健康老年人未来认知能力下降的预测因子。

• DOI: 10.1080/13803395.2013.877875
• 发表时间: 2014
• 期刊: Journal of clinical and experimental neuropsychology
• 影响因子: 2.2
• 作者: Sugarman,MichaelA;Woodard,JohnL;Nielson,KristyA;Smith,JCarson;Seidenberg,Michael;Durgerian,Sally;Norman,AndriaL;Hantke,NathanC;Rao,StephenM
• 通讯作者: Rao,StephenM

Interactive effects of physical activity and APOE-ε4 on white matter tract diffusivity in healthy elders.

体育活动和APOE-ε4对健康长老中白质扩散率的互动效应。

• DOI: 10.1016/j.neuroimage.2015.08.007
• 发表时间: 2016-05-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Smith JC;Lancaster MA;Nielson KA;Woodard JL;Seidenberg M;Durgerian S;Sakaie K;Rao SM
• 通讯作者: Rao SM