RR&D Research Career Scientist Application

RR

• 批准号: 10536800
• 负责人: Robert F. Kirsch
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10536800
• 关键词: Academia; Activities of Daily Living; Address; Algorithms; American; Amputees; Anatomy; Area; Artificial Intelligence; Biomedical Engineering; Brain; Caring; Cervical; Cervical spinal cord injury; Characteristics; Clinical; Communities; Custom; Development; Doctor of Philosophy; Education; Elbow; Electrodes; Engineering; Faculty; Funding; Hand; Health; Healthcare; Human; Human Resources; Incidence; Individual; Injury; Institutes; Intervention; Intuition; Journals; K-Series Research Career Programs; Laboratories; Leadership; Learning; Medical; Mentors; Methods; Military Personnel; Modeling; Movement; Muscle; Muscle Contraction; Muscle function; Musculoskeletal; Neck; Nerve; Orthotic Devices; Pain; Paralysed; Participant; Pattern; Persons; Population; Prosthesis; Proxy; Psychological reinforcement; Publications; Quadriplegia; Rehabilitation therapy; Research; Research Activity; Research Personnel; Research Project Grants; Role; Scientist; Seminal; Series; Services; Shoulder; Signal Transduction; Skeletal Muscle; Spinal Cord; Spinal cord injury; Study Section; System; Techniques; Training; Translational Research; Translations; United States; United States National Institutes of Health; Universities; Upper Extremity; Upper limb movement; Veterans; Volition; Work; arm; arm movement; brain computer interface; brain health; career; combat injury; design; disability; first-in-human; functional electrical stimulation; improved; member; nervous system disorder; neural implant; neural network; neuroregulation; neurorestoration; neurotechnology; novel; programs; prosthesis control; rehabilitation research; relating to nervous system; research and development; restoration; simulation; symposium; translational research program; undergraduate student

Dr. Kirsch has been a VA RR&D research for 28 years, and a VA RR&D Research Career Scientist since 2007. He has a very active research program and is a leader in both rehabilitation research and academia. His personal research activities focus on restoring shoulder, arm, and hand movements to individuals with extensive paralysis due to spinal cord injury (SCI). SCI is a devastating condition that often causes significant disability and loss of independence. Veterans are historically over-represented in the SCI population, and the incidence of SCI in more recent military engagements remains high. As a result, the VA Rehabilitation Research and Development Service has prioritized SCI research, and Dr. Kirsch’s research directly aligns with this priority. His research specifically focuses on restoring arm/hand movement to individuals with high cervical (C1-C4) SCI, a condition referred to as high tetraplegia, who have extensive paralysis below the neck. Such individuals are typically dependent on others for most aspects of care and activities of daily living. Dr. Kirsch has developed state-of-the-art (1) functional electrical stimulation (FES) systems for powering and coordinating arm and hand movements in people with high tetraplegia, (2) human brain-computer interfaces that allow users to intuitively command FES-powered arm movements, and (3) musculoskeletal models of the human shoulder and elbow that are modified to reflect the specific characteristics of individuals with SCI or other disabilities, and then used in simulation to explore the feasibility of an intervention (e.g., FES) and to optimize system design for clinical deployment, substantially decreasing experimental trial-and-error. Dr. Kirsch’s research work is well-funded, his publication record over the past five years has been very strong (quality and quantity), and he is a sought-after speaker for seminars and conferences. Dr. Kirsch has also undertaken a number of leadership roles in rehabilitation research. He has been the Executive Director of the VA RR&D-supported FES Center since January 2012. The FES Center is a global leader in neurostimulation/neuromodulation research that addresses the unmet rehabilitation needs of Veterans and civilians with neurological disorders. Specifically, the FES Center has 86 investigators (43 scientists/engineers and 43 clinicians) and almost 200 total personnel who perform and facilitate cutting edge research across 5 different rehabilitation research thrusts: (1) Movement Restoration, (2) Pain Mitigation, (3) Autonomic Restoration, (4) Brain Health, and (5) Translation and Clinical Dissemination. In addition, Dr. Kirsch is a leader in translational research, being a co-PI of the of a new VA center entitled the “VA Translational Education and Mentoring (VA-TEAM) Center” that is focused on educating and mentoring the VA’s most promising translational research projects across the US., as well as the PI of the Case-Coulter Translational Research Partnership, a nationally prominent program at Case Western Reserve University. Dr. Kirsch is very active in the national research and academic communities. He was a member of the VA RR&D Career Development Award panel for 10 years and was its Chair for 5 years. He has served on review panels for VA RR&D center applications, Research Career Scientist review panels, two standing NIH study sections, and more than 50 proposal review panels overall. He served as the host for the 2017 VA RR&D National Center/REAP Directors’ Retreat. He serves on 12 advisory or review boards for academic departments and research centers. Dr. Kirsch has been the Chair of Biomedical Engineering at Case Western Reserve University for 10 years. He served as Vice Chair (2016), Chair (2017), and Immediate Past Chair (2018) of the national Biomedical Engineering Council of Chairs, and was the host of the national Council of Chairs Educational Summit in 2019. He is a Fellow of the American Institute of Medical and Biological Engineering (AIMBE). He is a prolific mentor, having trained 17 PhD graduates and mentored large numbers of undergraduate students, young investigators, and faculty at several levels.

Kirsch博士从事VA RR&D研究已有28年，自2009年起担任VA RR&D研究职业科学家。 2007.他有一个非常活跃的研究计划，是康复研究和学术界的领导者。他 个人研究活动的重点是恢复肩，手臂和手部运动的个人， 由于脊髓损伤（SCI）引起的广泛瘫痪。SCI是一种破坏性的疾病， 残疾和失去独立性。退伍军人在SCI人群中的比例历来过高， 在最近的军事交战中SCI的发病率仍然很高。因此，VA康复 研究和发展服务优先考虑SCI研究，Kirsch博士的研究直接符合 这个优先级。他的研究特别关注恢复高颈椎病患者的手臂/手部运动。 （C1-C4）SCI，一种被称为高位四肢瘫痪的疾病，颈部以下广泛瘫痪。等 个人在日常生活的大部分护理和活动方面通常依赖于他人。基尔希博士 开发了最先进的（1）功能性电刺激（FES）系统，用于供电和协调 四肢瘫痪患者的手臂和手部运动，（2）允许用户 直观地命令FES驱动的手臂运动，以及（3）人类肩部的肌肉骨骼模型 和肘部，以反映SCI或其他残疾人的具体特征， 然后用于模拟以探索干预的可行性（例如，FES）和优化系统 设计用于临床部署，大大减少了实验性试错。基尔希博士的研究工作 资金充足，他在过去五年的出版记录非常强劲（质量和数量）， 他是研讨会和会议上广受欢迎的演讲者。 Kirsch博士还在康复研究中担任了许多领导角色。他一直是 自2012年1月起担任VA RR& D支持的FES中心执行主任。FES中心是一个全球性的 神经刺激/神经调节研究领域的领导者，致力于满足 退伍军人和患有神经系统疾病的平民。具体而言，FES中心有86名调查员（43 科学家/工程师和43名临床医生）和近200名执行和促进尖端技术的人员 5个不同康复研究方向的研究：（1）运动恢复，（2）疼痛缓解，（3） 自主神经恢复，（4）大脑健康，（5）翻译和临床传播。此外，Kirsch博士 是翻译研究的领导者，是一个名为“VA翻译”的新VA中心的共同PI 教育和指导（VA-TEAM）中心”，专注于教育和指导VA的最 美国各地有前途的转化研究项目，以及凯斯库尔特翻译公司的PI 研究伙伴关系，凯斯西储大学的一个全国著名的项目。 Kirsch博士在国家研究和学术界非常活跃。他是一个成员的 VA RR&D职业发展奖评审团10年，并担任其主席5年。他曾服务于 VA RR&D中心申请的审查小组，研究职业科学家审查小组，两个常设NIH 研究部门和50多个提案审查小组。他曾担任2017年VA RR&D的主持人 国家中心/REAP主任务虚会。他在12个学术咨询或审查委员会任职， 部门和研究中心。Kirsch博士一直是凯斯西方生物医学工程的主席 预备大学10年他曾担任副主席（2016年），主席（2017年）和前任主席 （2018年）的国家生物医学工程理事会主席，并主办了国家理事会的主席。 2019年主持教育峰会。他是美国医学和生物学会的会员 工程（AIMBE）。他是一位多产的导师，培养了17名博士毕业生，并指导了大量的 本科生，年轻的研究人员和教师在几个层次。