RESTORATION OF HAND AND ARM FUNCTION BY FNS

我们将部署4种新的上肢神经假体，覆盖所有级别的颈椎水平脊髓损伤（SCI），并有足够数量的受试者为未来更大规模的临床试验提供支持。所有这些神经假体都将使用植入的刺激器，其中3个将使用植入的肌电图记录模块。基于肌电图的控制算法将提供完全植入的指令和控制接口，同时利用受试者保留的自主功能。刺激和记录模块都将商业化生产，极大地促进了它们最终在一般临床环境中的部署。这个项目也将在几个重要的方面推动神经修复的前沿。通过与NICHD资助的平行项目合作，我们将致力于将更多的“脑机接口”作为神经假体命令接口用于高度颈脊髓不公正的个体。我们还将研究使用平面界面神经界面（FINE）从尽可能近端的位置激活多个肌肉的潜力，这可能会导致仅神经电极实施，手术影响更小。最后，我们将研究使用FINE作为记录手部皮肤神经束的接口，作为提供关于手部状态的皮肤电反馈的信息源。

We will deploy 4 new upper extremity neuroprostheses covering all elvels of cervical level spinal cord injuries (SCI) with sufficient numbers of subjects to provide support for larger clinical trials in the future. All of these neuroprostheses will use implanted stimulators and 3 of 4 2ill use implanted EMG recording modules. EMG-based control algorithms will provide fully implanted coman and control interfaces while exploiting the subjects' retained voluntary function. Both stimulation and recording odules will be commercially manufactured, greatly facilitating their eventual deployment in to the general clinical environment. This project will also push the frontiers of neuroprostheses in several significant ways. In collaboration with a parallel effort funded by NICHD, we will work to more "brain achine interfaces" into use as a neuroprosthesis command interface for individuals with high cervical spinal cord injusries. We will also examine the potential of useing the Flat Interface Nerve Interface (FINE) to activvate multiple muscles from as proximal a location as possible, potentially leading to a nerve electrode-only implementation with a lower surgical impact. Finally, we will examine the use of the FINE as an interface for recording from cutaneous enrve fascicles arising in the hand as a source of information for providing electrocutaneous feedback regarding the state of the hand.