RESTORATION OF HAND AND ARM FUNCTION BY FNS

我们将部署4个新的上肢神经假体，覆盖颈段脊髓损伤（SCI）的所有级别，有足够数量的受试者，为未来更大规模的临床试验提供支持。 所有这些神经假体都将使用植入式刺激器，4/2的患者将使用植入式EMG记录模块。 基于EMG的控制算法将提供完全植入的昏迷和控制界面，同时利用受试者保留的随意功能。 刺激和记录模块都将进行商业化生产，极大地促进其最终部署到一般临床环境中。 该项目还将在几个重要方面推动神经假体的前沿。 与NICHD资助的平行工作合作，我们将致力于更多的“脑机器人接口”，作为高颈脊髓不公正的个人的神经假体命令接口。 我们还将研究使用扁平接口神经接口（FINE）从尽可能近的位置激活多块肌肉的潜力，可能导致仅神经电极的实施，手术影响较低。 最后，我们将研究使用的罚款作为一个接口，记录从皮肤enrve束产生的手作为一个来源的信息，提供关于手的状态的皮肤电反馈。

We will deploy 4 new upper extremity neuroprostheses covering all elvels of cervical level spinal cord injuries (SCI) with sufficient numbers of subjects to provide support for larger clinical trials in the future. All of these neuroprostheses will use implanted stimulators and 3 of 4 2ill use implanted EMG recording modules. EMG-based control algorithms will provide fully implanted coman and control interfaces while exploiting the subjects' retained voluntary function. Both stimulation and recording odules will be commercially manufactured, greatly facilitating their eventual deployment in to the general clinical environment. This project will also push the frontiers of neuroprostheses in several significant ways. In collaboration with a parallel effort funded by NICHD, we will work to more "brain achine interfaces" into use as a neuroprosthesis command interface for individuals with high cervical spinal cord injusries. We will also examine the potential of useing the Flat Interface Nerve Interface (FINE) to activvate multiple muscles from as proximal a location as possible, potentially leading to a nerve electrode-only implementation with a lower surgical impact. Finally, we will examine the use of the FINE as an interface for recording from cutaneous enrve fascicles arising in the hand as a source of information for providing electrocutaneous feedback regarding the state of the hand.