RESTORATION OF HAND AND ARM FUNCTION BY FNS

我们将部署4个新的上肢神经假体，覆盖所有颈椎水平的脊髓损伤(SCI)，有足够的受试者数量，为未来更大规模的临床试验提供支持。所有这些神经假体都将使用植入的刺激器，42个神经假体中的3个将使用植入的肌电记录模块。基于肌电的控制算法将提供完全植入的命令和控制接口，同时利用受试者保留的自愿功能。刺激和记录模块都将被商业化制造，极大地促进了它们最终部署到一般临床环境中。该项目还将在几个重要方面推动神经假体的前沿。与NICHD资助的一项平行努力合作，我们将致力于将更多的“脑机接口”用作高位颈髓损伤患者的神经假体命令接口。我们还将研究使用平面界面神经接口(FINE)从尽可能近的位置激活多块肌肉的潜力，这可能会导致仅使用神经电极的实施，手术影响较小。最后，我们将研究FINE作为记录手部皮肤神经束的接口的使用，作为提供有关手部状态的皮肤电反馈的信息来源。

We will deploy 4 new upper extremity neuroprostheses covering all elvels of cervical level spinal cord injuries (SCI) with sufficient numbers of subjects to provide support for larger clinical trials in the future. All of these neuroprostheses will use implanted stimulators and 3 of 4 2ill use implanted EMG recording modules. EMG-based control algorithms will provide fully implanted coman and control interfaces while exploiting the subjects' retained voluntary function. Both stimulation and recording odules will be commercially manufactured, greatly facilitating their eventual deployment in to the general clinical environment. This project will also push the frontiers of neuroprostheses in several significant ways. In collaboration with a parallel effort funded by NICHD, we will work to more "brain achine interfaces" into use as a neuroprosthesis command interface for individuals with high cervical spinal cord injusries. We will also examine the potential of useing the Flat Interface Nerve Interface (FINE) to activvate multiple muscles from as proximal a location as possible, potentially leading to a nerve electrode-only implementation with a lower surgical impact. Finally, we will examine the use of the FINE as an interface for recording from cutaneous enrve fascicles arising in the hand as a source of information for providing electrocutaneous feedback regarding the state of the hand.