Center for Functional Electrical Stimulation

功能性电刺激中心

• 批准号: 10043833
• 负责人: Robert F. Kirsch
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-10-01 至 2022-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10043833
• 关键词: Area; Autonomic nervous system; Bladder; Brain; Caring; Clinical; Collaborations; Communication; Communities; Core Facility; Desire for food; Development; Disease; Economics; Effectiveness; Electric Stimulation; Electrodes; Engineering; Environment; Epilepsy; Evolution; Foundations; Funding; Future; General Population; Goals; Growth; Hypertension; Industrialization; Inflammation; Infrastructure; Injury; Intervention; Intestines; Knowledge; Leadership; Limb structure; Medical Illustration; Mental disorders; Modeling; Movement; Movement Disorders; Nervous System Trauma; Nervous system structure; Neurologic; Neurons; Neurophysiology - biologic function; Pain; Parkinson Disease; Patients; Peripheral Nerve Stimulation; Productivity; Regulation; Rehabilitation therapy; Research; Research Personnel; Research Training; Resources; Scientist; Services; Spinal Cord; Spinal cord injury; Stroke; Structure; System; Techniques; Technology; Traumatic Brain Injury; Veterans; Visceral; base; brain health; career development; chronic pain; community building; disability; effective therapy; functional electrical stimulation; innovation; inter-institutional; models and simulation; nervous system disorder; neuropsychiatric disorder; novel strategies; rehabilitation research; research and development; respiratory; restoration; success; tool; tool development

The Center for Functional Electrical Stimulation (FES Center) is a 25 year consortium that develops and deploys rehabilitation treatments based on functional electrical stimulation (FES) for Veterans and civilians with neurological, autonomic, psychiatric, pain, and other disorders. The VISION of the Cleveland FES Center is broad - to perform cutting edge research and creative engineering, and to then transition these discoveries and technologies into the clinical environment to create effective, clinically-available options for patients and the people who care for them. The MISSION of the FES Center, however, is very clear and tightly focused - to develop interventions based on the electrical stimulation of the nervous system to replace or compensate for natural neural function lost due to neurological disease or injury. The scope of FES Center research has evolved and expanded significantly during the current five year funding cycle to reflect new scientific discoveries and new clinical opportunities. This proposal represents this evolution and thus describes the five research thrusts of the FES Center for the next five years: (1) MOVEMENT RESTORATION: restoring limb, respiratory, and other body movements; (2) BRAIN HEALTH: brain stimulation interventions for movement disorders (e.g., Parkinson's disease), stroke and traumatic brain injuries, epilepsy, and neuropsychiatric disorders, as well as brain recording technologies; (3) PAIN: pain mitigation through stimulation of peripheral nerves and the spinal cord; (4) AUTONOMIC SYSTEMS: autonomic nervous system stimulation for restoration and/or regulation of internal body and visceral functions; and (5) TECHNOLOGY AND TOOLS: development of basic stimulation techniques, implantable systems and electrodes, modeling and simulation tools, and other rehabilitation approaches complementary to FES. These seemingly diverse research thrusts in fact share a deep foundation of basic knowledge, use similar and often identical technologies, and rely on a proven model of genuine clinical-technical partnerships. The FES Center has built a critical mass of investigators in each of these research thrust areas, and will continue to pursue research in important new clinical areas where FES may provide effective treatments. FES Center research thrusts are tightly aligned with the priorities of the VA RR&D Service, and FES Center investigators are leaders in the national and local rehabilitation communities. The FES Center operates with core funding from the VA Rehabilitation Research and Development Service and uses these resources to broadly enable the success of its investigators by providing a unique technical infrastructure, specialized research services (regulatory, statistical, medical illustration, inter-institutional administrative support), development of key industrial and academic relationships, and communication to potential patients, other scientists, and to the general public. The consortium structure of the FES Center continues to effectively leverage the amazingly rich academic and clinical expertise across the Cleveland area. The FES Center focus on community building, collaboration and inclusion, and shared infrastructure – rather than on funding specific projects – has promoted continuous innovation and growth, enabled MANY investigators to successfully pursue major projects that would otherwise be impractical, and has realized economic efficiencies through core facilities and economies of scale. AND, the FES Center has steered this major enterprise to focus on the rehabilitation challenges of Veterans! The FES Center and its investigators have been highly successful over the past five years in terms of research productivity and collaboration, clinical impact, leadership in rehabilitation research, and training and career development of VA investigators. We have developed ambitious but obtainable goals for the coming 5 years, as well as a clear plan for achieving these goals. The FES Center will continue to provide core resources that can be leveraged by our investigators and their interdisciplinary teams to conduct unique, cutting-edge research and clinical deployment. The scope of FES Center research has been expanded over the past five years, but our overriding objective - to achieve increasingly meaningful impact on the lives of Veterans and civilians with disabilities - remains unchanged. The FES Center is thus poised to have continued impact on rehabilitation research into the future.

功能性电刺激中心（FES中心）是一个25年的联盟，开发和部署 康复治疗基于功能性电刺激（FES）为退伍军人和平民与神经， 自主神经、精神、疼痛和其他疾病。克利夫兰FES中心的愿景是广泛的-执行 尖端的研究和创造性的工程，然后将这些发现和技术转化为 临床环境，为患者和护理他们的人创造有效的、临床可用的选择。的 然而，FES中心的使命非常明确，重点非常突出--根据 神经系统的电刺激，以替代或补偿由于 神经系统疾病或损伤。FES中心的研究范围在2000年期间得到了显著的发展和扩大。 目前的五年资助周期，以反映新的科学发现和新的临床机会。这项建议 代表了这种演变，因此描述了FES中心未来五年的五个研究重点：（1） 运动恢复：恢复肢体、呼吸和其他身体运动;（2）大脑健康：大脑 用于运动障碍的刺激干预（例如，帕金森氏病），中风和创伤性脑损伤， 癫痫和神经精神疾病，以及大脑记录技术;（3）疼痛：通过 刺激周围神经和脊髓;（4）自主神经系统：自主神经系统 刺激恢复和/或调节体内和内脏功能;以及（5）技术和 工具：开发基本刺激技术、植入式系统和电极、建模和仿真 工具和其他与FES互补的康复方法。这些看似多样化的研究方向 共享基础知识的深厚基础，使用相似且通常相同的技术，并依赖于经过验证的 真正的临床技术合作模式。FES中心已经在每个国家建立了足够数量的调查人员， 这些研究重点领域，并将继续在重要的新的临床领域进行研究，其中FES可能 提供有效的治疗。FES中心的研究重点与VA RR&D的优先事项密切相关 服务和FES中心的调查人员是国家和地方康复社区的领导者。 FES中心的核心资金来自VA康复研究和发展服务， 利用这些资源，通过提供独特的技术基础设施， 专业研究服务（监管、统计、医学插图、机构间行政支持）， 发展关键的工业和学术关系，并与潜在患者，其他科学家， 以及公众的关注FES中心的联盟结构继续有效地利用 令人惊讶的丰富的学术和临床专业知识在整个克利夫兰地区。FES中心专注于社区 建设、合作和包容以及共享基础设施--而不是资助具体项目-- 促进了持续的创新和增长，使许多调查人员能够成功地从事重大项目， 否则将是不切实际的，并通过核心设施和经济实现了经济效益， 规模而且，FES中心已经引导这个主要的企业专注于退伍军人的康复挑战！ FES中心及其研究人员在过去五年中在研究方面取得了巨大成功 生产力和协作，临床影响，康复研究领导力，培训和职业生涯 研究人员的发展。我们也为未来5年制定了雄心勃勃但可以实现的目标 作为实现这些目标的明确计划。FES中心将继续提供核心资源， 通过我们的研究人员及其跨学科团队进行独特的，尖端的研究和临床 部署. FES中心的研究范围在过去五年中有所扩大，但我们最重要的是 目标--对退伍军人和残疾平民的生活产生越来越有意义的影响--仍然是 不变因此，FES中心准备对未来的康复研究产生持续的影响。