Center for Functional Electrical Stimulation

功能性电刺激中心

• 批准号: 10043833
• 负责人: Robert F. Kirsch
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-10-01 至 2022-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10043833
• 关键词: Area; Autonomic nervous system; Bladder; Brain; Caring; Clinical; Collaborations; Communication; Communities; Core Facility; Desire for food; Development; Disease; Economics; Effectiveness; Electric Stimulation; Electrodes; Engineering; Environment; Epilepsy; Evolution; Foundations; Funding; Future; General Population; Goals; Growth; Hypertension; Industrialization; Inflammation; Infrastructure; Injury; Intervention; Intestines; Knowledge; Leadership; Limb structure; Medical Illustration; Mental disorders; Modeling; Movement; Movement Disorders; Nervous System Trauma; Nervous system structure; Neurologic; Neurons; Neurophysiology - biologic function; Pain; Parkinson Disease; Patients; Peripheral Nerve Stimulation; Productivity; Regulation; Rehabilitation therapy; Research; Research Personnel; Research Training; Resources; Scientist; Services; Spinal Cord; Spinal cord injury; Stroke; Structure; System; Techniques; Technology; Traumatic Brain Injury; Veterans; Visceral; base; brain health; career development; chronic pain; community building; disability; effective therapy; functional electrical stimulation; innovation; inter-institutional; models and simulation; nervous system disorder; neuropsychiatric disorder; novel strategies; rehabilitation research; research and development; respiratory; restoration; success; tool; tool development

The Center for Functional Electrical Stimulation (FES Center) is a 25 year consortium that develops and deploys rehabilitation treatments based on functional electrical stimulation (FES) for Veterans and civilians with neurological, autonomic, psychiatric, pain, and other disorders. The VISION of the Cleveland FES Center is broad - to perform cutting edge research and creative engineering, and to then transition these discoveries and technologies into the clinical environment to create effective, clinically-available options for patients and the people who care for them. The MISSION of the FES Center, however, is very clear and tightly focused - to develop interventions based on the electrical stimulation of the nervous system to replace or compensate for natural neural function lost due to neurological disease or injury. The scope of FES Center research has evolved and expanded significantly during the current five year funding cycle to reflect new scientific discoveries and new clinical opportunities. This proposal represents this evolution and thus describes the five research thrusts of the FES Center for the next five years: (1) MOVEMENT RESTORATION: restoring limb, respiratory, and other body movements; (2) BRAIN HEALTH: brain stimulation interventions for movement disorders (e.g., Parkinson's disease), stroke and traumatic brain injuries, epilepsy, and neuropsychiatric disorders, as well as brain recording technologies; (3) PAIN: pain mitigation through stimulation of peripheral nerves and the spinal cord; (4) AUTONOMIC SYSTEMS: autonomic nervous system stimulation for restoration and/or regulation of internal body and visceral functions; and (5) TECHNOLOGY AND TOOLS: development of basic stimulation techniques, implantable systems and electrodes, modeling and simulation tools, and other rehabilitation approaches complementary to FES. These seemingly diverse research thrusts in fact share a deep foundation of basic knowledge, use similar and often identical technologies, and rely on a proven model of genuine clinical-technical partnerships. The FES Center has built a critical mass of investigators in each of these research thrust areas, and will continue to pursue research in important new clinical areas where FES may provide effective treatments. FES Center research thrusts are tightly aligned with the priorities of the VA RR&D Service, and FES Center investigators are leaders in the national and local rehabilitation communities. The FES Center operates with core funding from the VA Rehabilitation Research and Development Service and uses these resources to broadly enable the success of its investigators by providing a unique technical infrastructure, specialized research services (regulatory, statistical, medical illustration, inter-institutional administrative support), development of key industrial and academic relationships, and communication to potential patients, other scientists, and to the general public. The consortium structure of the FES Center continues to effectively leverage the amazingly rich academic and clinical expertise across the Cleveland area. The FES Center focus on community building, collaboration and inclusion, and shared infrastructure – rather than on funding specific projects – has promoted continuous innovation and growth, enabled MANY investigators to successfully pursue major projects that would otherwise be impractical, and has realized economic efficiencies through core facilities and economies of scale. AND, the FES Center has steered this major enterprise to focus on the rehabilitation challenges of Veterans! The FES Center and its investigators have been highly successful over the past five years in terms of research productivity and collaboration, clinical impact, leadership in rehabilitation research, and training and career development of VA investigators. We have developed ambitious but obtainable goals for the coming 5 years, as well as a clear plan for achieving these goals. The FES Center will continue to provide core resources that can be leveraged by our investigators and their interdisciplinary teams to conduct unique, cutting-edge research and clinical deployment. The scope of FES Center research has been expanded over the past five years, but our overriding objective - to achieve increasingly meaningful impact on the lives of Veterans and civilians with disabilities - remains unchanged. The FES Center is thus poised to have continued impact on rehabilitation research into the future.

功能电刺激中心（FES中心）是一个25年的财团，发展和部署 基于功能电刺激（FES）的康复治疗 自主，精神病，疼痛和其他疾病。克利夫兰FES中心的愿景很广 - 表演 尖端的研究和创意工程，然后将这些发现和技术转变为 临床环境为患者和照顾他们的人创造有效的，临床上可用的选择。 但是 神经系统的电刺激以替换或补偿由于 神经疾病或损伤。 FES中心研究的范围在此期间已经显着发展和扩展 当前的五年资金周期，以反映新的科学发现和新的临床机会。这个建议 代表这种演变，因此在未来五年中描述了FES中心的五个研究推力：（1） 运动恢复：恢复肢体，呼吸道和其他身体运动； （2）大脑健康：大脑 刺激运动障碍的干预措施（例如帕金森氏病），中风和创伤性脑损伤， 癫痫和神经精神疾病以及大脑记录技术； （3）疼痛：缓解疼痛 刺激周围神经系统和脊髓； （4）自主系统：自主神经系统 刺激内部身体和内脏功能的恢复和/或调节； （5）技术和 工具：基本仿真技术，可植入系统和电极的开发，建模和仿真 工具和其他康复方法可以完成FES。这些看似多样的研究实际上是 分享基础知识的深刻基础，使用相似且通常相同的技术，并依靠已验证的技术 真正的临床技术伙伴关系模型。 FES中心在每个 这些研究推动了领域，并将继续在FES可能的重要新临床领域进行研究 提供有效的治疗方法。 FES中心的研究推力与VA RR＆D的优先级紧密相符 服务和FES中心的调查人员是国家和地方康复社区的领导者。 FES中心通过VA康复研究与开发服务局的核心资助以及 利用这些资源来广泛地通过提供独特的技术基础设施，即 专业研究服务（监管，统计，医学插图，机构间行政支持）， 建立关键的工业和学术关系，以及与潜在的患者，其他科学家的沟通， 并向公众。 FES中心的财团结构继续有效地利用 克利夫兰地区的学术和临床专业知识令人惊叹。 FES中心专注于社区 建造，协作和包容性以及共享基础架构（而不是在特定项目上） 促进了持续的创新和增长，使许多调查人员能够成功地追求主要项目 否则将是不切实际的，并通过核心设施和经济学实现了经济效率 规模。而且，FES中心已经蒸蒸日上了这一主要企业，专注于退伍军人的康复挑战！ 在过去的五年中，FES中心及其调查人员在研究中取得了非常成功 生产力和协作，临床影响，康复研究领导力以及培训和职业 VA调查人员的发展。我们已经建立了雄心勃勃的目标，但在未来5年中也可以实现 作为实现这些目标的明确计划。 FES中心将继续提供可以是的核心资源 我们的调查人员及其跨学科团队利用了独特的，尖端的研究和临床 部署。在过去的五年中，FES中心研究的范围已经扩大，但是我们的压倒力 目标 - 对退伍军人和残疾平民的生活产生越来越有意义的影响 - 仍然是 不变。因此，FES中心被中毒，以继续对未来的康复研究产生影响。