Center for Functional Electrical Stimulation

功能性电刺激中心(FES Center)是一个有25年历史的联盟，开发和部署 基于功能性电刺激(FES)的退伍军人和平民神经疾病康复治疗， 自主神经、精神、疼痛和其他障碍。克利夫兰FES中心的视野是广阔的-执行 尖端研究和创意工程，然后将这些发现和技术转化为 临床环境，为患者和护理他们的人创造有效的、临床可用的选择。这个 然而，FES中心的使命是非常明确和密切关注的--根据 电刺激神经系统，以取代或补偿因以下原因而丧失的自然神经功能 神经性疾病或损伤。在此期间，FES中心的研究范围得到了显著的发展和扩大 目前的五年筹资周期，以反映新的科学发现和新的临床机会。这项建议 代表了这一演变，并由此描述了FES中心在未来五年的五个研究重点：(1) 运动恢复：恢复肢体、呼吸和其他身体运动；(2)大脑健康：大脑 对运动障碍(如帕金森氏病)、中风和创伤性脑损伤的刺激干预， 癫痫和神经精神障碍，以及脑记录技术；(3)疼痛：通过 刺激周围神经和脊髓；(4)自主系统：自主神经系统 对恢复和/或调节体内和内脏功能的刺激；和(5)技术和 工具：开发基本刺激技术、植入式系统和电极、建模和仿真 工具和其他康复方法作为对残疾家庭教育的补充。这些看似多样化的研究实际上推动了 共享深厚的基本知识基础，使用相似且往往相同的技术，并依赖于经过验证的 真正的临床-技术伙伴关系的典范。FES中心在每一个地方都建立了足够多的调查人员 这些研究主要集中在领域，并将继续在重要的新临床领域进行研究，在这些领域 提供有效的治疗。FES中心的研究努力与退伍军人管理局RR&D的优先事项紧密结合 服务和FES中心的调查人员是国家和地方康复社区的领导者。 FES中心由退伍军人康复研究和发展局提供核心资金，并 利用这些资源，通过提供独特的技术基础设施，使其调查人员能够取得广泛的成功， 专门研究服务(监管、统计、医学说明、机构间行政支助)， 发展关键的产业和学术关系，并与潜在患者、其他科学家、 以及对普通公众来说。FES中心的联合体结构继续有效地利用 克利夫兰地区令人惊讶的丰富的学术和临床专业知识。FES中心专注于社区 建设、协作和包容以及共享基础设施--而不是为特定项目提供资金--具有 促进持续创新和增长，使许多研究人员能够成功地开展重大项目 否则是不切实际的，并已通过核心设施和经济实现了经济效率 比例。而且，FES中心已经引导这家主要企业专注于退伍军人的康复挑战！ 在过去的五年里，FES中心及其调查人员在研究方面取得了巨大的成功 工作效率和协作、临床影响、康复研究领域的领导地位以及培训和职业生涯 发展退伍军人管理局调查人员。我们也为未来5年制定了雄心勃勃但可以实现的目标 作为实现这些目标的明确计划。FES中心将继续提供核心资源，可以 利用我们的研究人员及其跨学科团队进行独特、尖端的研究和临床 部署。FES中心的研究范围在过去五年中有所扩大，但我们的压倒一切 目标--对残疾退伍军人和平民的生活产生越来越有意义的影响 保持不变。因此，FES中心将继续对未来的康复研究产生影响。

The Center for Functional Electrical Stimulation (FES Center) is a 25 year consortium that develops and deploys rehabilitation treatments based on functional electrical stimulation (FES) for Veterans and civilians with neurological, autonomic, psychiatric, pain, and other disorders. The VISION of the Cleveland FES Center is broad - to perform cutting edge research and creative engineering, and to then transition these discoveries and technologies into the clinical environment to create effective, clinically-available options for patients and the people who care for them. The MISSION of the FES Center, however, is very clear and tightly focused - to develop interventions based on the electrical stimulation of the nervous system to replace or compensate for natural neural function lost due to neurological disease or injury. The scope of FES Center research has evolved and expanded significantly during the current five year funding cycle to reflect new scientific discoveries and new clinical opportunities. This proposal represents this evolution and thus describes the five research thrusts of the FES Center for the next five years: (1) MOVEMENT RESTORATION: restoring limb, respiratory, and other body movements; (2) BRAIN HEALTH: brain stimulation interventions for movement disorders (e.g., Parkinson's disease), stroke and traumatic brain injuries, epilepsy, and neuropsychiatric disorders, as well as brain recording technologies; (3) PAIN: pain mitigation through stimulation of peripheral nerves and the spinal cord; (4) AUTONOMIC SYSTEMS: autonomic nervous system stimulation for restoration and/or regulation of internal body and visceral functions; and (5) TECHNOLOGY AND TOOLS: development of basic stimulation techniques, implantable systems and electrodes, modeling and simulation tools, and other rehabilitation approaches complementary to FES. These seemingly diverse research thrusts in fact share a deep foundation of basic knowledge, use similar and often identical technologies, and rely on a proven model of genuine clinical-technical partnerships. The FES Center has built a critical mass of investigators in each of these research thrust areas, and will continue to pursue research in important new clinical areas where FES may provide effective treatments. FES Center research thrusts are tightly aligned with the priorities of the VA RR&D Service, and FES Center investigators are leaders in the national and local rehabilitation communities. The FES Center operates with core funding from the VA Rehabilitation Research and Development Service and uses these resources to broadly enable the success of its investigators by providing a unique technical infrastructure, specialized research services (regulatory, statistical, medical illustration, inter-institutional administrative support), development of key industrial and academic relationships, and communication to potential patients, other scientists, and to the general public. The consortium structure of the FES Center continues to effectively leverage the amazingly rich academic and clinical expertise across the Cleveland area. The FES Center focus on community building, collaboration and inclusion, and shared infrastructure – rather than on funding specific projects – has promoted continuous innovation and growth, enabled MANY investigators to successfully pursue major projects that would otherwise be impractical, and has realized economic efficiencies through core facilities and economies of scale. AND, the FES Center has steered this major enterprise to focus on the rehabilitation challenges of Veterans! The FES Center and its investigators have been highly successful over the past five years in terms of research productivity and collaboration, clinical impact, leadership in rehabilitation research, and training and career development of VA investigators. We have developed ambitious but obtainable goals for the coming 5 years, as well as a clear plan for achieving these goals. The FES Center will continue to provide core resources that can be leveraged by our investigators and their interdisciplinary teams to conduct unique, cutting-edge research and clinical deployment. The scope of FES Center research has been expanded over the past five years, but our overriding objective - to achieve increasingly meaningful impact on the lives of Veterans and civilians with disabilities - remains unchanged. The FES Center is thus poised to have continued impact on rehabilitation research into the future.