Translational Coordination and Dissemination Center for the SCGE Consortium

SCGE 联盟翻译协调和传播中心

• 批准号: 10666211
• 负责人: MELINDA R DWINELL
• 金额: $ 130.26万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10666211
• 关键词: Academia; Acceleration; Biological Assay; Clinic; Clinical Trials; Collaborations; Communication; Communities; Complex; Data; Data Element; Development; Education and Outreach; Educational Activities; Educational workshop; Elements; Foundations; Funding; Goals; Government; Individual; Industry; Infrastructure; Leadership; Organ; Outcome; Participant; Patients; Phase; Policies; Procedures; Process; Protocols documentation; Research Design; Research Personnel; Research Project Grants; Resources; Schedule; Series; System; Technology; Testing; Tissues; Translating; Translational Research; Translations; United States National Institutes of Health; Validation; Visualization; Wisconsin; Work; data access; data format; data management; data quality; disease-causing mutation; distributed data; ethical, legal, and social implication; experience; genome editing; medical schools; meetings; member; outreach; pre-clinical; preclinical study; programs; scientific organization; somatic cell gene editing; success; tool; translational goal; user-friendly; virtual; working group

PROJECT SUMMARY The goal of the NIH Common Fund’s Somatic Cell Genome Editing (SCGE) program is to take advances in technologies aimed at genome editing and delivery system approaches to correct disease-causing mutations developed in Phase I and translate these efforts into the clinic during Phase II. The SCGE Translational Coordination and Dissemination Center (TCDC) at the Medical College of Wisconsin (MCW) will continue the efforts of the Phase I SCGE Dissemination and Coordinating Center acting as the hub to support the three lab and clinical trials-based initiatives in a coordinated effort to facilitate the dissemination of protocols, best practices, SCGE results, and develop a network of collaboration. The SCGE TCDC at MCW brings a team of experienced investigators, platforms for effective communication and tracking of deliverables and milestones and demonstrated success in strategic collaborations within the consortium. The overall goal for the SCGE TCDC is to support the SCGE Consortium and work cooperatively with all initiatives, projects, and members to facilitate the objectives of the entire SCGE Consortium. To accomplish this, the MCW TCDC will 1) build upon and extend the current communication platforms to facilitate communication among participants, 2) develop the infrastructure to collect, digest, annotate, integrate, and distribute data and resources generated within the SCGE Consortium, and 3) create a robust platform for collaboration within the SCGE Consortium and with outside partners. The MCW TCDC will create the infrastructure to develop policies, track progress within the consortium, communicate within and beyond the consortium, develop outreach and educational activities to support the process of moving pre-clinical studies through the regulatory process, into clinical trials, and eventually to the patient. To disseminate data and resources developed within the SCGE Consortium, the SCGE Platform will be assembled to store, query, visualize, and analyze the outcomes of the SCGE initiatives. The MCW TCDC team will facilitate the administrative and management activities to support the overall success of the program.

项目总结