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Hybrid Rat Diversity Program

杂交大鼠多样性计划

基本信息

批准号：
9923779
负责人：
MELINDA R DWINELL
金额：
$ 76.95万
依托单位：
MEDICAL COLLEGE OF WISCONSIN
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9923779
关键词：
Aging Alcohols Animal Model Animal Sources Animals Anxiety Arthritis Asthma Biological Breeding Characteristics Colorado Communities Complex Cryopreservation Czech Republic DNA Sequence Data Data Analyses Diabetes Mellitus Disease Disease susceptibility Drug usage Elements Embryo Ensure Environment Environmental Impact Environmental Risk Factor Europe Exercise Exposure to Female Future Genes Genetic Genetic Heterogeneity Genetic Models Genetic Polymorphism Genetic Predisposition to Disease Genetic Transcription Genetic Variation Genetic study Genome Genomics Goals Grant Human Hybrids Hypertension Inbred Strain Inbred Strains Rats Inbreeding Infrastructure International Japan Knowledge Laboratory Research Link Location Maintenance Malignant Neoplasms Maps Missouri Modeling Molecular Monoclonal Antibody R24 Nature Pharmacogenomics Phenotype Physiological Positioning Attribute Rat Genome Database Rattus Recombinant Inbred Strain Recombinants Recovery Reproducibility Research Research Personnel Resources Resuscitation Rodent Model Sample Size Site Source Stable Populations Stroke Study models System Techniques Technology Therapeutic Time Tissues Translations Treatment Efficacy Universities Variant Wisconsin animal resource behavioral phenotyping biobank catalyst clinical translation clinically relevant cost data reuse disease mechanisms study drug development drug discovery embryo cryopreservation experimental study genetic resource genome browser genome sequencing genomic data genomic locus male medical schools molecular phenotype mortality phenotypic data potential biomarker precision medicine preference programs reproductive therapeutic target tool trait transcriptome transcriptomics translational medicine whole genome

项目摘要

The overall goal of this program is to extend the use of rat models for clinical translation through establishing an animal resource and genomic dataset to facilitate the translation of laboratory research to clinical relevance. Specifically, this project will develop the Hybrid Rat Diversity Panel (HRDP) as the source of the animal models and baseline molecular and physiological phenotypes underlying the National Rat Genetics Resource Program. To achieve this goal, we propose the following four specific aims: 1) to establish the 96 strain Hybrid Rat Diversity Panel comprised of 33 classic inbred strains, 30 HXB/BXH recombinant inbred strains and 33 FEXL/LXFE recombinant inbred strains, 2) to phenotypically characterize, maintain and distribute the HRDP, 3) to complete genomic sequencing on the full HRDP and 4) and provide data analysis, integration and dissemination primarily through the Rat Genome Database (RGD). This resource will be used to study mechanisms of complex disease traits through systems genetics by providing access to a renewable panel of inbred rat strains and biobanked tissues, reusable phenotypic data, reusable genomic sequence and strain specific variants, and the infrastructure to explore, analyze and visualize these resources through the HRDP Portal at RGD. The HRDP will have broad utility to the scientific community through the genetic and phenotypic diversity represented in the 96 strain panel used to study hypertension, stroke, diabetes, cancer, arthritis, reproductive disorders, asthma, aging, alcohol preference, anxiety, and exercise.

该计划的总体目标是通过以下方式扩展大鼠模型在临床翻译中的应用建立动物资源和基因组数据集，以促进实验室翻译临床相关性的研究。具体而言，该项目将开发杂交鼠多样性作为动物模型和基线分子和生理学来源的样本组（HRDP）国家大鼠遗传资源计划的基础表型。为了实现这一目标，我们提出以下四个具体目标：1）建立96系杂交鼠多样性小组包括33个经典自交系、30个HXB/BXH重组自交系和33个 FEXL/LXFE重组近交系，2）表型表征、维持和分发HRDP，3）完成完整HRDP的基因组测序，4）并提供主要通过大鼠基因组数据库进行数据分析、整合和传播（RGD）。该资源将用于研究复杂疾病特征的机制，系统遗传学通过提供可再生的小组近交系大鼠品系和生物库组织、可重复使用的表型数据、可重复使用的基因组序列和菌株特异性变体，以及通过HRDP门户网站探索、分析和可视化这些资源的基础设施， RGD。HRDP将通过遗传学和生物学的方法对科学界产生广泛的效用。在用于研究高血压，中风，糖尿病、癌症、关节炎、生殖障碍、哮喘、衰老、酗酒、焦虑，和锻炼。