Hybrid Rat Diversity Program
杂交大鼠多样性计划
基本信息
- 批准号:9923779
- 负责人:
- 金额:$ 76.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2022-04-30
- 项目状态:已结题
- 来源:
- 关键词:AgingAlcoholsAnimal ModelAnimal SourcesAnimalsAnxietyArthritisAsthmaBiologicalBreedingCharacteristicsColoradoCommunitiesComplexCryopreservationCzech RepublicDNA SequenceDataData AnalysesDiabetes MellitusDiseaseDisease susceptibilityDrug usageElementsEmbryoEnsureEnvironmentEnvironmental ImpactEnvironmental Risk FactorEuropeExerciseExposure toFemaleFutureGenesGeneticGenetic HeterogeneityGenetic ModelsGenetic PolymorphismGenetic Predisposition to DiseaseGenetic TranscriptionGenetic VariationGenetic studyGenomeGenomicsGoalsGrantHumanHybridsHypertensionInbred StrainInbred Strains RatsInbreedingInfrastructureInternationalJapanKnowledgeLaboratory ResearchLinkLocationMaintenanceMalignant NeoplasmsMapsMissouriModelingMolecularMonoclonal Antibody R24NaturePharmacogenomicsPhenotypePhysiologicalPositioning AttributeRat Genome DatabaseRattusRecombinant Inbred StrainRecombinantsRecoveryReproducibilityResearchResearch PersonnelResourcesResuscitationRodent ModelSample SizeSiteSourceStable PopulationsStrokeStudy modelsSystemTechniquesTechnologyTherapeuticTimeTissuesTranslationsTreatment EfficacyUniversitiesVariantWisconsinanimal resourcebehavioral phenotypingbiobankcatalystclinical translationclinically relevantcostdata reusedisease mechanisms studydrug developmentdrug discoveryembryo cryopreservationexperimental studygenetic resourcegenome browsergenome sequencinggenomic datagenomic locusmalemedical schoolsmolecular phenotypemortalityphenotypic datapotential biomarkerprecision medicinepreferenceprogramsreproductivetherapeutic targettooltraittranscriptometranscriptomicstranslational medicinewhole genome
项目摘要
The overall goal of this program is to extend the use of rat models for clinical translation through
establishing an animal resource and genomic dataset to facilitate the translation of laboratory
research to clinical relevance. Specifically, this project will develop the Hybrid Rat Diversity
Panel (HRDP) as the source of the animal models and baseline molecular and physiological
phenotypes underlying the National Rat Genetics Resource Program. To achieve this goal, we
propose the following four specific aims: 1) to establish the 96 strain Hybrid Rat Diversity Panel
comprised of 33 classic inbred strains, 30 HXB/BXH recombinant inbred strains and 33
FEXL/LXFE recombinant inbred strains, 2) to phenotypically characterize, maintain and
distribute the HRDP, 3) to complete genomic sequencing on the full HRDP and 4) and provide
data analysis, integration and dissemination primarily through the Rat Genome Database
(RGD). This resource will be used to study mechanisms of complex disease traits through
systems genetics by providing access to a renewable panel of inbred rat strains and biobanked
tissues, reusable phenotypic data, reusable genomic sequence and strain specific variants, and
the infrastructure to explore, analyze and visualize these resources through the HRDP Portal at
RGD. The HRDP will have broad utility to the scientific community through the genetic and
phenotypic diversity represented in the 96 strain panel used to study hypertension, stroke,
diabetes, cancer, arthritis, reproductive disorders, asthma, aging, alcohol preference, anxiety,
and exercise.
该计划的总体目标是通过以下方式扩展大鼠模型在临床翻译中的应用
建立动物资源和基因组数据集,以促进实验室翻译
临床相关性的研究。具体而言,该项目将开发杂交鼠多样性
作为动物模型和基线分子和生理学来源的样本组(HRDP)
国家大鼠遗传资源计划的基础表型。为了实现这一目标,我们
提出以下四个具体目标:1)建立96系杂交鼠多样性小组
包括33个经典自交系、30个HXB/BXH重组自交系和33个
FEXL/LXFE重组近交系,2)表型表征、维持和
分发HRDP,3)完成完整HRDP的基因组测序,4)并提供
主要通过大鼠基因组数据库进行数据分析、整合和传播
(RGD)。该资源将用于研究复杂疾病特征的机制,
系统遗传学通过提供可再生的小组近交系大鼠品系和生物库
组织、可重复使用的表型数据、可重复使用的基因组序列和菌株特异性变体,以及
通过HRDP门户网站探索、分析和可视化这些资源的基础设施,
RGD。HRDP将通过遗传学和生物学的方法对科学界产生广泛的效用。
在用于研究高血压,中风,
糖尿病、癌症、关节炎、生殖障碍、哮喘、衰老、酗酒、焦虑,
和锻炼。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MELINDA R DWINELL其他文献
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{{ truncateString('MELINDA R DWINELL', 18)}}的其他基金
Translational Coordination and Dissemination Center for the SCGE Consortium
SCGE 联盟翻译协调和传播中心
- 批准号:
10666211 - 财政年份:2023
- 资助金额:
$ 76.95万 - 项目类别:
Translational Coordination and Dissemination Center for the SCGE Consortium
SCGE 联盟翻译协调和传播中心
- 批准号:
10908953 - 财政年份:2023
- 资助金额:
$ 76.95万 - 项目类别:
Dissemination and Coordinating Center for the SCGE Consortium
SCGE 联盟传播和协调中心
- 批准号:
10531271 - 财政年份:2019
- 资助金额:
$ 76.95万 - 项目类别:
Dissemination and Coordinating Center for the SCGE Consortium
SCGE 联盟传播和协调中心
- 批准号:
10063999 - 财政年份:2019
- 资助金额:
$ 76.95万 - 项目类别:
Dissemination and Coordinating Center for the SCGE Consortium
SCGE 联盟传播和协调中心
- 批准号:
10331318 - 财政年份:2019
- 资助金额:
$ 76.95万 - 项目类别:
Hybrid Rat Diversity Program - cryopreservation resource for rat models
杂交大鼠多样性计划 - 大鼠模型的冷冻保存资源
- 批准号:
10609632 - 财政年份:2018
- 资助金额:
$ 76.95万 - 项目类别:
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