Translational Coordination and Dissemination Center for the SCGE Consortium

项目总结 NIH共同基金的体细胞基因组编辑(SCGE)计划的目标是 针对基因组编辑和递送系统的技术进展 在第一阶段产生致病突变，并将这些努力转化为临床 第二阶段：SCGE翻译协调和传播中心(TCDC) 威斯康星医学院(MCW)将继续第一阶段SCGE的努力 以传播协调中心为枢纽支持三个实验室和临床 以试验为基础的倡议，以协调努力促进议定书的传播，最好 实践、SCGE结果，并建立协作网络。MCW的SCGE TCDC 带来了一支经验丰富的调查团队，为有效的沟通和跟踪提供了平台 交付成果和里程碑，并在以下领域的战略协作中取得成功 财团。SCGE技合中心的总体目标是支持SCGE联盟和工作 与所有倡议、项目和成员合作，以促进整个 SCGE联盟。为了实现这一目标，MCW技合中心将1)建立和扩展 目前的交流平台，以促进参与者之间的交流，2)开发 用于收集、消化、注释、集成和分发生成的数据和资源的基础架构 在SCGE联盟内，以及3)在SCGE内创建强大的协作平台 财团和外部合作伙伴之间的合作。MCW TCDC将创建基础设施以开发 政策，跟踪联合体内的进展，在联合体内外进行沟通， 开展外展和教育活动，以支持推进临床前研究的进程 通过监管过程，进入临床试验，最终到达患者。传播 在SCGE联盟内开发的数据和资源，SCGE平台将是 集合起来存储、查询、可视化和分析SCGE倡议的结果。这个 MCW TCDC团队将促进行政和管理活动，以支持 该计划总体上取得了成功。

PROJECT SUMMARY The goal of the NIH Common Fund’s Somatic Cell Genome Editing (SCGE) program is to take advances in technologies aimed at genome editing and delivery system approaches to correct disease-causing mutations developed in Phase I and translate these efforts into the clinic during Phase II. The SCGE Translational Coordination and Dissemination Center (TCDC) at the Medical College of Wisconsin (MCW) will continue the efforts of the Phase I SCGE Dissemination and Coordinating Center acting as the hub to support the three lab and clinical trials-based initiatives in a coordinated effort to facilitate the dissemination of protocols, best practices, SCGE results, and develop a network of collaboration. The SCGE TCDC at MCW brings a team of experienced investigators, platforms for effective communication and tracking of deliverables and milestones and demonstrated success in strategic collaborations within the consortium. The overall goal for the SCGE TCDC is to support the SCGE Consortium and work cooperatively with all initiatives, projects, and members to facilitate the objectives of the entire SCGE Consortium. To accomplish this, the MCW TCDC will 1) build upon and extend the current communication platforms to facilitate communication among participants, 2) develop the infrastructure to collect, digest, annotate, integrate, and distribute data and resources generated within the SCGE Consortium, and 3) create a robust platform for collaboration within the SCGE Consortium and with outside partners. The MCW TCDC will create the infrastructure to develop policies, track progress within the consortium, communicate within and beyond the consortium, develop outreach and educational activities to support the process of moving pre-clinical studies through the regulatory process, into clinical trials, and eventually to the patient. To disseminate data and resources developed within the SCGE Consortium, the SCGE Platform will be assembled to store, query, visualize, and analyze the outcomes of the SCGE initiatives. The MCW TCDC team will facilitate the administrative and management activities to support the overall success of the program.