Translational Coordination and Dissemination Center for the SCGE Consortium
Translational Coordination and Dissemination Center for the SCGE Consortium
批准号:
10908953
负责人:
MELINDA R DWINELL
金额:
$4.0万
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-06-01 至 2028-05-31
关键词:
AcademiaAccelerationBiological AssayClinicClinical TrialsCollaborationsCommunicationCommunitiesComplexDataData ElementDevelopmentEducation and OutreachEducational ActivitiesEducational workshopElementsFoundationsFundingGoalsGovernmentIndividualIndustryInfrastructureLeadershipOrganOutcomeParticipantPatientsPhasePoliciesProceduresProcessProtocols documentationResearch DesignResearch PersonnelResearch Project GrantsResourcesScheduleSeriesSystemTechnologyTestingTissuesTranslatingTranslational ResearchTranslationsUnited States National Institutes of HealthValidationVisualizationWisconsinWorkdata accessdata formatdata managementdata qualitydisease-causing mutationdistributed dataethical, legal, and social implicationexperiencegenome editingmedical schoolsmeetingsmemberoutreachpre-clinicalpreclinical studyprogramsscientific organizationsomatic cell gene editingsuccesstooltranslational goaluser-friendlyvirtualworking group
中文摘要
项目总结
NIH共同基金的体细胞基因组编辑(SCGE)计划的目标是
针对基因组编辑和递送系统的技术进展
在第一阶段产生致病突变,并将这些努力转化为临床
第二阶段:SCGE翻译协调和传播中心(TCDC)
威斯康星医学院(MCW)将继续第一阶段SCGE的努力
以传播协调中心为枢纽支持三个实验室和临床
以试验为基础的倡议,以协调努力促进议定书的传播,最好
实践、SCGE结果,并建立协作网络。MCW的SCGE TCDC
带来了一支经验丰富的调查团队,为有效的沟通和跟踪提供了平台
交付成果和里程碑,并在以下领域的战略协作中取得成功
财团。SCGE技合中心的总体目标是支持SCGE联盟和工作
与所有倡议、项目和成员合作,以促进整个
SCGE联盟。为了实现这一目标,MCW技合中心将1)建立和扩展
目前的交流平台,以促进参与者之间的交流,2)开发
用于收集、消化、注释、集成和分发生成的数据和资源的基础架构
在SCGE联盟内,以及3)在SCGE内创建强大的协作平台
财团和外部合作伙伴之间的合作。MCW TCDC将创建基础设施以开发
政策,跟踪联合体内的进展,在联合体内外进行沟通,
开展外展和教育活动,以支持推进临床前研究的进程
通过监管过程,进入临床试验,最终到达患者。传播
在SCGE联盟内开发的数据和资源,SCGE平台将是
集合起来存储、查询、可视化和分析SCGE倡议的结果。这个
MCW TCDC团队将促进行政和管理活动,以支持
该计划总体上取得了成功。
英文摘要
PROJECT SUMMARY
The goal of the NIH Common Fund’s Somatic Cell Genome Editing (SCGE) program is to take
advances in technologies aimed at genome editing and delivery system approaches to correct
disease-causing mutations developed in Phase I and translate these efforts into the clinic during
Phase II. The SCGE Translational Coordination and Dissemination Center (TCDC) at the
Medical College of Wisconsin (MCW) will continue the efforts of the Phase I SCGE
Dissemination and Coordinating Center acting as the hub to support the three lab and clinical
trials-based initiatives in a coordinated effort to facilitate the dissemination of protocols, best
practices, SCGE results, and develop a network of collaboration. The SCGE TCDC at MCW
brings a team of experienced investigators, platforms for effective communication and tracking
of deliverables and milestones and demonstrated success in strategic collaborations within the
consortium. The overall goal for the SCGE TCDC is to support the SCGE Consortium and work
cooperatively with all initiatives, projects, and members to facilitate the objectives of the entire
SCGE Consortium. To accomplish this, the MCW TCDC will 1) build upon and extend the
current communication platforms to facilitate communication among participants, 2) develop the
infrastructure to collect, digest, annotate, integrate, and distribute data and resources generated
within the SCGE Consortium, and 3) create a robust platform for collaboration within the SCGE
Consortium and with outside partners. The MCW TCDC will create the infrastructure to develop
policies, track progress within the consortium, communicate within and beyond the consortium,
develop outreach and educational activities to support the process of moving pre-clinical studies
through the regulatory process, into clinical trials, and eventually to the patient. To disseminate
data and resources developed within the SCGE Consortium, the SCGE Platform will be
assembled to store, query, visualize, and analyze the outcomes of the SCGE initiatives. The
MCW TCDC team will facilitate the administrative and management activities to support the
overall success of the program.
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Translational Coordination and Dissemination Center for the SCGE Consortium
-
批准号:10666211
-
项目类别:
-
资助金额:$130.26万
-
财政年份:2023
-
负责人:MELINDA R DWINELL
-
依托单位:
Dissemination and Coordinating Center for the SCGE Consortium
-
批准号:10531271
-
项目类别:
-
资助金额:$114.49万
-
财政年份:2019
-
负责人:MELINDA R DWINELL
-
依托单位:
Dissemination and Coordinating Center for the SCGE Consortium
-
批准号:10063999
-
项目类别:
-
资助金额:$422.02万
-
财政年份:2019
-
负责人:MELINDA R DWINELL
-
依托单位:
Dissemination and Coordinating Center for the SCGE Consortium
-
批准号:10331318
-
项目类别:
-
资助金额:$422.02万
-
财政年份:2019
-
负责人:MELINDA R DWINELL
-
依托单位:
Hybrid Rat Diversity Program
-
批准号:10215989
-
项目类别:
-
资助金额:$32.63万
-
财政年份:2018
-
负责人:MELINDA R DWINELL
-
依托单位:
Hybrid Rat Diversity Program - cryopreservation resource for rat models
-
批准号:10609632
-
项目类别:
-
资助金额:$20.34万
-
财政年份:2018
-
负责人:MELINDA R DWINELL
-
依托单位:
Hybrid Rat Diversity Program
-
批准号:10598105
-
项目类别:
-
资助金额:$77.85万
-
财政年份:2018
-
负责人:MELINDA R DWINELL
-
依托单位:
Hybrid Rat Diversity Program
-
批准号:9923779
-
项目类别:
-
资助金额:$76.95万
-
财政年份:2018
-
负责人:MELINDA R DWINELL
-
依托单位:
Hybrid Rat Diversity Program
-
批准号:9752686
-
项目类别:
-
资助金额:$76.38万
-
财政年份:2018
-
负责人:MELINDA R DWINELL
-
依托单位:
Hybrid Rat Diversity Program
-
批准号:10411190
-
项目类别:
-
资助金额:$77.94万
-
财政年份:2018
-
负责人:MELINDA R DWINELL
-
依托单位:
Gene targeted rat resource for the study of complex disease
-
批准号:8849963
-
项目类别:
-
资助金额:$184.25万
-
财政年份:2013
-
负责人:MELINDA R DWINELL
-
依托单位:
Gene targeted rat resource for the study of complex disease
-
批准号:9069959
-
项目类别:
-
资助金额:$171.71万
-
财政年份:2013
-
负责人:MELINDA R DWINELL
-
依托单位:
Gene targeted rat resource for the study of complex disease
-
批准号:9279218
-
项目类别:
-
资助金额:$149.66万
-
财政年份:2013
-
负责人:MELINDA R DWINELL
-
依托单位:
Integration of phenotype data from multiple centers using ontologies
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批准号:7933480
-
项目类别:
-
资助金额:$37.74万
-
财政年份:2010
-
负责人:MELINDA R DWINELL
-
依托单位:
Integration of phenotype data from multiple centers using ontologies
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批准号:8293181
-
项目类别:
-
资助金额:$37.62万
-
财政年份:2010
-
负责人:MELINDA R DWINELL
-
依托单位:
Integration of phenotype data from multiple centers using ontologies
-
批准号:8109936
-
项目类别:
-
资助金额:$38.0万
-
财政年份:2010
-
负责人:MELINDA R DWINELL
-
依托单位:
海外基金