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中文摘要
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项目摘要 NIH共同基金的体细胞基因组编辑(SCGE)计划的目标是 旨在基因组编辑和递送系统方法的技术进展, 致病突变在I期发展,并将这些努力转化为临床, 第二阶段。常设委员会翻译协调和传播中心(技合中心) 威斯康星州医学院(MCW)将继续第一阶段SCGE的工作 传播和协调中心作为中心,支持三个实验室和临床 以审判为基础的举措,协调努力,促进传播议定书, 实践,SCGE结果,并建立合作网络。MCW的SCGE TCDC 拥有一支经验丰富的调查团队,有效沟通和跟踪的平台 可交付成果和里程碑,并在内部战略合作中取得成功 财团SCGE TCDC的总体目标是支持SCGE联合会, 与所有倡议,项目和成员合作,以促进整个目标 SCGE财团。为实现这一目标,军事和妇女发展中国家间技术合作将:1)在 现有的交流平台,以促进参与者之间的交流,2)开发 收集、摘要、注释、集成和分发生成的数据和资源的基础设施 在SCGE联盟内,以及3)在SCGE内创建一个强大的协作平台 联合体和外部合作伙伴。MCW技合将建立基础设施, 政策,跟踪联盟内的进展,在联盟内外进行沟通, 开展推广和教育活动,以支持临床前研究的转移过程 通过监管程序,进入临床试验,最终到达患者。传播 在SCGE联盟内开发的数据和资源,SCGE平台将 集合以存储、查询、可视化和分析SCGE计划的结果。的 军事和妇女部技合小组将促进行政和管理活动, 计划的全面成功。
英文摘要
PROJECT SUMMARY The goal of the NIH Common Fund’s Somatic Cell Genome Editing (SCGE) program is to take advances in technologies aimed at genome editing and delivery system approaches to correct disease-causing mutations developed in Phase I and translate these efforts into the clinic during Phase II. The SCGE Translational Coordination and Dissemination Center (TCDC) at the Medical College of Wisconsin (MCW) will continue the efforts of the Phase I SCGE Dissemination and Coordinating Center acting as the hub to support the three lab and clinical trials-based initiatives in a coordinated effort to facilitate the dissemination of protocols, best practices, SCGE results, and develop a network of collaboration. The SCGE TCDC at MCW brings a team of experienced investigators, platforms for effective communication and tracking of deliverables and milestones and demonstrated success in strategic collaborations within the consortium. The overall goal for the SCGE TCDC is to support the SCGE Consortium and work cooperatively with all initiatives, projects, and members to facilitate the objectives of the entire SCGE Consortium. To accomplish this, the MCW TCDC will 1) build upon and extend the current communication platforms to facilitate communication among participants, 2) develop the infrastructure to collect, digest, annotate, integrate, and distribute data and resources generated within the SCGE Consortium, and 3) create a robust platform for collaboration within the SCGE Consortium and with outside partners. The MCW TCDC will create the infrastructure to develop policies, track progress within the consortium, communicate within and beyond the consortium, develop outreach and educational activities to support the process of moving pre-clinical studies through the regulatory process, into clinical trials, and eventually to the patient. To disseminate data and resources developed within the SCGE Consortium, the SCGE Platform will be assembled to store, query, visualize, and analyze the outcomes of the SCGE initiatives. The MCW TCDC team will facilitate the administrative and management activities to support the overall success of the program.
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Translational Coordination and Dissemination Center for the SCGE Consortium
  • 批准号:
    10666211
  • 项目类别:
  • 资助金额:
    $130.26万
  • 财政年份:
    2023
  • 负责人:
    MELINDA R DWINELL
  • 依托单位:
Dissemination and Coordinating Center for the SCGE Consortium
  • 批准号:
    10531271
  • 项目类别:
  • 资助金额:
    $114.49万
  • 财政年份:
    2019
  • 负责人:
    MELINDA R DWINELL
  • 依托单位:
Dissemination and Coordinating Center for the SCGE Consortium
  • 批准号:
    10063999
  • 项目类别:
  • 资助金额:
    $422.02万
  • 财政年份:
    2019
  • 负责人:
    MELINDA R DWINELL
  • 依托单位:
Dissemination and Coordinating Center for the SCGE Consortium
  • 批准号:
    10331318
  • 项目类别:
  • 资助金额:
    $422.02万
  • 财政年份:
    2019
  • 负责人:
    MELINDA R DWINELL
  • 依托单位:
海外基金