NorthStar Node of the Clinical Trials Network

临床试验网络的 NorthStar 节点

• 批准号: 10682035
• 负责人: GAVIN BART
• 金额: $ 23.15万
• 依托单位: HENNEPIN HEALTHCARE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-11 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10682035
• 关键词: Abstinence; Address; Adoption; Adult; Advisory Committees; Affect; Alaska Native; American Indians; Biological; COVID-19 pandemic; Chronic; Clinical Trials Network; Communities; Development; Enrollment; Evaluation; Facebook; Gender; Generations; Geographic Locations; HIV; Health; Hepatitis C; Intervention; Lead; Media Intervention; Minnesota; Modeling; Morbidity - disease rate; National Institute of Drug Abuse; Opioid; Overdose; Participant; Pharmaceutical Preparations; Pharmacotherapy; Phase; Population; Protocols documentation; Public Health; Randomized; Recovery; Recovery Support; Relapse; Research; Resources; Risk; Site; Social Network; Social support; Stress and Coping; Testing; Time; Trauma; United States; Woman; active control; addiction; base; comparison intervention; cultural values; design; digital; effectiveness trial; evidence base; experience; healthcare community; high risk; medication-assisted treatment; men; mortality; opioid use; opioid use disorder; perceived stress; prevent; resilience; social; social health determinants; social media; stress management; stress reactivity; substance use; therapy development; uptake; virtual

Project Summary Since the COVID-19 pandemic, American Indian and Alaska Native (AIAN) adults now experience the highest rate of drug overdose in the United States, which is 31% higher than that of White adults.1 AI/AN adults are particularly at high risk for opioid use disorder (OUD) due to elevated risk of chronic health conditions influenced primarily by social determinants of health, as well as historical trauma.2 Illicit use of opioids is a major public health problem associated with significant morbidity and mortality related to HIV, hepatitis C, and overdose.3-5 AIAN adults in Minnesota are seven times more likely to die of an overdose involving opioids than whites, representing the greatest disparity observed between AIAN and whites in the US.6 Medication for opioid use disorder (MOUD) is an evidence-based approach,7-9 and strategies to promote the continuation of pharmacotherapy and support OUD recovery are important.10,11 Gender-specific factors affecting opioid use relapse and recovery that are more prevalent in women compared with men include perceived stress, trauma, and enhanced biological stress reactivity; as well as less social support for abstinence.12,13 AIAN gender- specific interventions for OUD do not exist. Research has documented the positive impact of social networks and social support on abstinence from substance use.145 However, understanding how best to leverage social support remains a key challenge for the addictions treatment field.15 In NIDA CTN-0123 (Aim 1) we are addressing these gaps by developing a social digital (Facebook) intervention to promote stress management and social network support for opioid abstinence among AIAN women. Especially with the COVID-19 pandemic, virtual digital platforms have potential for greater reach and scale.16,17 Consistent with the AIAN cultural value of interdependence, social media-formed groups to prevent opioid relapse could lead to greater adoption and sustainability by encouraging collaborative efforts across generations of AIAN women and leveraging community resilience for coping with stress.18-21 The overall research objective is to develop and evaluate the feasibility of a Facebook intervention for supporting recovery from opioid use among AIAN women. This project was designed with community partners at the MN Indian Women’s Resource Center (MIWRC). A community advisory committee (CAC) contributed to the development of the Facebook intervention content and study protocol for Aim 1 (NIDA CTN 0123) and will continue to guide all study activities for the Aim 2 pilot RCT proposed here.

项目摘要 自从Covid-19大流行以来 在美国，药物过量的速率比白人成人高31％。1AI/AN成年人是 特别是由于慢性健康状况的风险升高而导致阿片类药物使用障碍（OUD）的高风险 主要受健康的社会决定者以及历史创伤的影响。2非法使用阿片类药物是一种 与艾滋病毒，丙型肝炎和 服用过量。明尼苏达州的3-5名艾安成年人死于涉及阿片类药物的过量的可能性是 白人，代表美国艾安和白人之间观察到的最大差距。6药物 Oopioid使用障碍（MOUD）是一种基于证据的方法，7-9和促进延续的策略 药物治疗和支持OUD恢复很重要。10,11影响使用阿片类药物的性别特定因素 与男性相比，女性更普遍的接力和恢复包括感知的压力，创伤， 并增强了生物胁迫反应性；以及对禁欲的社会支持较少。12,13Aian性别 - 不存在针对OUD的具体干预措施。研究记录了社交网络的积极影响 145但是，了解如何最好地利用社会 支持仍然是增加治疗领域的关键挑战。15在NIDA CTN-0123中（AIM 1）我们是 通过开发社交数字（Facebook）干预来促进压力管理来解决这些差距 和社交网络支持Aian妇女的阿片类药物禁欲。特别是与19号 大流行，虚拟数字平台有可能获得更大的覆盖范围和规模。16,17与Aian一致 相互依存的文化价值，社交媒体形成的群体以防止阿片类中继导致更大 通过鼓励几代艾安妇女的合作努力，采用和可持续性 利用社区的韧性应对压力。18-21总体研究目标是发展和 评估Facebook干预以支持Aian中阿片类药物使用恢复的可行性 女性。该项目是由MN印度妇女资源中心的社区合作伙伴设计的 （MIWRC）。社区咨询委员会（CAC）为Facebook的发展做出了贡献 AIM 1（NIDA CTN 0123）的干预内容和研究方案，并将继续指导所有研究 AIM 2 PILOT RCT的活动在这里提出。