NorthStar Node of the Clinical Trials Network

临床试验网络的 NorthStar 节点

• 批准号: 10682035
• 负责人: GAVIN BART
• 金额: $ 23.15万
• 依托单位: HENNEPIN HEALTHCARE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-11 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10682035
• 关键词: Abstinence; Address; Adoption; Adult; Advisory Committees; Affect; Alaska Native; American Indians; Biological; COVID-19 pandemic; Chronic; Clinical Trials Network; Communities; Development; Enrollment; Evaluation; Facebook; Gender; Generations; Geographic Locations; HIV; Health; Hepatitis C; Intervention; Lead; Media Intervention; Minnesota; Modeling; Morbidity - disease rate; National Institute of Drug Abuse; Opioid; Overdose; Participant; Pharmaceutical Preparations; Pharmacotherapy; Phase; Population; Protocols documentation; Public Health; Randomized; Recovery; Recovery Support; Relapse; Research; Resources; Risk; Site; Social Network; Social support; Stress and Coping; Testing; Time; Trauma; United States; Woman; active control; addiction; base; comparison intervention; cultural values; design; digital; effectiveness trial; evidence base; experience; healthcare community; high risk; medication-assisted treatment; men; mortality; opioid use; opioid use disorder; perceived stress; prevent; resilience; social; social health determinants; social media; stress management; stress reactivity; substance use; therapy development; uptake; virtual

Project Summary Since the COVID-19 pandemic, American Indian and Alaska Native (AIAN) adults now experience the highest rate of drug overdose in the United States, which is 31% higher than that of White adults.1 AI/AN adults are particularly at high risk for opioid use disorder (OUD) due to elevated risk of chronic health conditions influenced primarily by social determinants of health, as well as historical trauma.2 Illicit use of opioids is a major public health problem associated with significant morbidity and mortality related to HIV, hepatitis C, and overdose.3-5 AIAN adults in Minnesota are seven times more likely to die of an overdose involving opioids than whites, representing the greatest disparity observed between AIAN and whites in the US.6 Medication for opioid use disorder (MOUD) is an evidence-based approach,7-9 and strategies to promote the continuation of pharmacotherapy and support OUD recovery are important.10,11 Gender-specific factors affecting opioid use relapse and recovery that are more prevalent in women compared with men include perceived stress, trauma, and enhanced biological stress reactivity; as well as less social support for abstinence.12,13 AIAN gender- specific interventions for OUD do not exist. Research has documented the positive impact of social networks and social support on abstinence from substance use.145 However, understanding how best to leverage social support remains a key challenge for the addictions treatment field.15 In NIDA CTN-0123 (Aim 1) we are addressing these gaps by developing a social digital (Facebook) intervention to promote stress management and social network support for opioid abstinence among AIAN women. Especially with the COVID-19 pandemic, virtual digital platforms have potential for greater reach and scale.16,17 Consistent with the AIAN cultural value of interdependence, social media-formed groups to prevent opioid relapse could lead to greater adoption and sustainability by encouraging collaborative efforts across generations of AIAN women and leveraging community resilience for coping with stress.18-21 The overall research objective is to develop and evaluate the feasibility of a Facebook intervention for supporting recovery from opioid use among AIAN women. This project was designed with community partners at the MN Indian Women’s Resource Center (MIWRC). A community advisory committee (CAC) contributed to the development of the Facebook intervention content and study protocol for Aim 1 (NIDA CTN 0123) and will continue to guide all study activities for the Aim 2 pilot RCT proposed here.

项目概要 自 COVID-19 大流行以来，美洲印第安人和阿拉斯加原住民 (AIAN) 成年人现在经历了最高的 美国的药物过量发生率比白人成年人高 31%。1 AI/AN 成年人 由于慢性健康问题的风险增加，特别是阿片类药物使用障碍 (OUD) 的高风险人群 主要受到健康问题社会决定因素以及历史创伤的影响。2 非法使用阿片类药物是一个 与艾滋病毒、丙型肝炎和艾滋病相关的显着发病率和死亡率相关的重大公共卫生问题 过量。明尼苏达州的 3-5 名 AIAN 成年人死于阿片类药物过量的可能性是其七倍 白人，代表了在美国 AIAN 和白人之间观察到的最大差异。 6 药物治疗 阿片类药物使用障碍 (MOUD) 是一种基于证据的方法，7-9 以及促进持续使用的策略 药物治疗和支持 OUD 恢复很重要。10,11 影响阿片类药物使用的性别特定因素 与男性相比，女性更容易复发和恢复，包括感知到的压力、创伤、 和增强的生物应激反应性；以及对禁欲的社会支持较少。12,13 AIAN 性别- 针对 OUD 的具体干预措施并不存在。研究记录了社交网络的积极影响 145 然而，了解如何最好地利用社会支持 支持仍然是成瘾治疗领域的一个关键挑战。15 在 NIDA CTN-0123（目标 1）中，我们 通过开发社交数字 (Facebook) 干预措施来促进压力管理来解决这些差距 以及社交网络对 AIAN 女性戒除阿片类药物的支持。尤其是面对新冠肺炎 (COVID-19) 大流行期间，虚拟数字平台有可能扩大影响范围和规模。16,17 与 AIAN 一致 相互依存的文化价值，社交媒体形成的防止阿片类药物复发的团体可能会导致更大的 通过鼓励几代 AIAN 女性和女性的合作努力来实现采用和可持续性 利用社区复原力应对压力。18-21 总体研究目标是开发和 评估 Facebook 干预支持 AIAN 从阿片类药物使用中恢复的可行性 女性。该项目是与明尼苏达州印第安妇女资源中心的社区合作伙伴共同设计的 （MIWRC）。社区咨询委员会 (CAC) 为 Facebook 的发展做出了贡献 目标 1 (NIDA CTN 0123) 的干预内容和研究方案，并将继续指导所有研究 此处建议的 Aim 2 试点 RCT 活动。