NorthStar Node of the Clinical Trials Network

自2015年加入NIDA国家药物滥用治疗临床试验网络(CTN)以来，北极星 NODE为CTN的目标和优先事项作出了重大贡献。北极星节点及其 调查人员领导或共同领导了五项CTN方案，作为七项CTN研究的研究地点，共同 担任CTN指导委员会和数据科学工作组主席，参与研究 发展委员会，并为几个特殊利益集团作出了贡献。北极星节点的研究 研究组合包括传统随机对照试验(CTN-0068)、实用比较有效性 研究(CTN-0098A和CTN-0099)、实施科学(CTN-0074、CTN-0098B和CTN-0099)、 基于社区的参与性研究(CTN-0096)、数据科学(CTN-0076和CTN-0087)和健康 服务研究(CTN-0070)。在此应用程序中，北极星节点有七个指导目标 (北极星)：1)生成为政策和临床指南提供信息的证据；2)评估模型 3)使用学习型健康的原则解决同时发生的SUD以及医疗和精神疾病 进行实用试验的系统；4)使用人工智能和其他数据科学方法 加强SUD研究和护理；5)接触未充分研究的人群，以确保SUD研究与 不同人群；6)使用执行科学测试基于证据的可持续发展做法的整合 应用到普通医疗环境中；以及7)测试SUD治疗的创新策略。需要满足的潜在研究 这些目标包括1)一种治疗甲基苯丙胺使用障碍的新疗法；2) 机器学习算法在电子健康档案靶向物质使用筛选中的应用 并加强药物使用障碍的诊断；3)利用人群进行精准/个性化的医学研究 药代动力学，以更好地定义和改进用药策略，以改善治疗结果；以及 4)测试协作护理模式，以应对专业成瘾患者的共生慢性疾病 治疗设置。我们的专业知识涵盖多个地点的临床试验、实施科学、基于社区的 参与性研究、基于电子病历的干预、机器学习和自然语言处理，以及 健康服务研究。除了包括城乡一体化保健在内的社区合作伙伴 系统，联邦合格的卫生中心为代表不足的少数民族提供服务，专门的成瘾治疗 项目以及儿科和青少年健康诊所，北极星节点带来了附属的研究和 传播网络进入CTN，包括CTSA、SIREN、PCORnet、JCOIN、HOPE、The Network 成瘾技术转移中心协调办公室，一个学习健康系统培训计划 (K12)，三个NIDA培训方案(T32)，以及成瘾药物和成瘾研究金方案 精神病学。北极星节点非常适合解决当前和新出现的SUD问题并推动 在这一领域进行研究，以改善患者的预后和改变卫生系统。

Since joining the NIDA National Drug Abuse Treatment Clinical Trials Network (CTN) in 2015, the NorthStar Node has made significant contributions to the objectives and priorities of the CTN. The NorthStar Node and its investigators have led or co-led five CTN protocols, served as a research site for seven CTN studies, co- chaired the CTN Steering Committee and the Data Science Work Group, served on the Research Development Committee, and contributed to several special interest groups. The NorthStar Node's research portfolio includes traditional randomized controlled trials (CTN-0068), pragmatic comparative effectiveness research (CTN-0098A and CTN-0099), implementation science (CTN-0074, CTN-0098B, and CTN-0099), community-based participatory research (CTN-0096), data science (CTN-0076 and CTN-0087), and health services research (CTN-0070). In this application, the NorthStar Node has seven guiding objectives (POLARIS): 1) generating evidence that informs Policy and clinical guidelines; 2) evaluating models addressing co-Occurring SUD and medical and psychiatric conditions; 3) using principals of a Learning health system to conduct pragmatic trials; 4) using Artificial intelligence and other data sciences approaches to enhance SUD research and care; 5) Reaching understudied populations to ensure SUD research is relevant to diverse populations; 6) using Implementation science to test the integration of evidence-based SUD practices into general medical settings; and 7) testing innovative Strategies for SUD treatment. Potential studies to meet these objectives include 1) a novel therapeutic intervention for methamphetamine use disorder; 2) development of machine learning algorithms in the electronic health record to target substance use screening and enhance substance use disorder diagnoses; 3) precision/personalized medicine studies using population pharmacokinetics to better define and refine medication dosing strategies that improve treatment outcome; and 4) testing collaborative care models to address co-occurring chronic medical illnesses in specialty addiction treatment settings. Our expertise spans multi-site clinical trials, implementation science, community-based participatory research, EHR-based interventions, machine learning and natural language processing, and health services research. In addition to community partners that include urban and rural integrated health systems, federally qualified health centers serving underrepresented minorities, specialty addiction treatment programs, and pediatric and adolescent health clinics, the NorthStar Node brings affiliated research and dissemination networks into the CTN, including CTSA, SIREN, PCORNet, JCOIN, HOPE, the Network Coordinating Office of the Addiction Technology Transfer Centers, a learning health system training program (K12), three NIDA training programs (T32), and fellowship programs in addiction medicine and addiction psychiatry. The NorthStar Node is well situated to address current and emerging SUD issues and advance research in the field in order to improve patient outcome and transform health systems.