NorthStar Node of the Clinical Trials Network

临床试验网络的 NorthStar 节点

• 批准号: 10583144
• 负责人: GAVIN BART
• 金额: $ 650.79万
• 依托单位: HENNEPIN HEALTHCARE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10583144
• 关键词: Address; Adoption; Algorithms; American; Artificial Intelligence; Big Data; Cannabis; Cardiovascular Diseases; Caring; Childhood; Chronic; Chronic Disease; Clinic; Clinical; Clinical Research; Clinical Sciences; Clinical Treatment; Clinical Trials Network; Communities; Comparative Effectiveness Research; Counseling; County; Criminal Justice; Data Science; Development; Diagnosis; Disease Outcome; Dose; Drug Kinetics; Drug abuse; Drug user; Electronic Health Record; Ensure; Federally Qualified Health Center; Fellowship Program; Guidelines; HIV; Health; Health Personnel; Health Services Research; Health system; Healthcare; Helping to End Addiction Long-term; Homelessness; Housing; Human Resources; Infrastructure; Institutes; Institution; Integrated Health Care Systems; Intervention; Iowa; Learning; Machine Learning; Major Depressive Disorder; Medical; Medicine; Mental disorders; Mentors; Methamphetamine; Methamphetamine use disorder; Midwestern United States; Minnesota; Mission; Modeling; Multi-Institutional Clinical Trial; National Institute of Drug Abuse; Natural Language Processing; Neurosciences; North Dakota; Opiate Addiction; Opioid; Outcome; Patient Care; Patient-Focused Outcomes; Patients; Persons; Pharmaceutical Preparations; Policies; Population; Population Heterogeneity; Positioning Attribute; Primary Health Care; Protocols documentation; Psychiatry; Public Health; Public Health Informatics; Randomized Controlled Trials; Recovery; Research; Research Personnel; Rural; SECTM1 gene; Scientist; Site; Social Work; South Dakota; Speed; Student Health Services; Substance Use Disorder; Sum; Technology Transfer; Testing; Training; Training Programs; Translating; Translational Research; Translations; Treatment outcome; Underrepresented Minority; United States National Institutes of Health; Universities; Viral hepatitis; Wisconsin; Workforce Development; addiction; adolescent health; base; career; clinical practice; cognitive training; collaborative care; community based participatory research; community engagement; comorbidity; evidence base; health care delivery; health care service utilization; illicit drug use; implementation science; improved; innovation; machine learning algorithm; medical specialties; novel therapeutic intervention; novel therapeutics; opioid misuse; personalized medicine; pragmatic implementation; pragmatic trial; precision medicine; predictive modeling; research and development; research data dissemination; rural area; safety net; screening; special interest group; substance use; treatment program; university student; urban Native American; urban area; working group

This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative bolsters research across NIH to improve treatment for opioid misuse and addiction. Since joining the NIDA National Drug Abuse Treatment Clinical Trials Network (CTN) in 2015, the NorthStar Node has made significant contributions to the objectives and priorities of the CTN. The NorthStar Node and its investigators have led or co-led five CTN protocols, served as a research site for seven CTN studies, co- chaired the CTN Steering Committee and the Data Science Work Group, served on the Research Development Committee, and contributed to several special interest groups. The NorthStar Node's research portfolio includes traditional randomized controlled trials (CTN-0068), pragmatic comparative effectiveness research (CTN-0098A and CTN-0099), implementation science (CTN-0074, CTN-0098B, and CTN-0099), community-based participatory research (CTN-0096), data science (CTN-0076 and CTN-0087), and health services research (CTN-0070). In this application, the NorthStar Node has seven guiding objectives (POLARIS): 1) generating evidence that informs Policy and clinical guidelines; 2) evaluating models addressing co-Occurring SUD and medical and psychiatric conditions; 3) using principals of a Learning health system to conduct pragmatic trials; 4) using Artificial intelligence and other data sciences approaches to enhance SUD research and care; 5) Reaching understudied populations to ensure SUD research is relevant to diverse populations; 6) using Implementation science to test the integration of evidence-based SUD practices into general medical settings; and 7) testing innovative Strategies for SUD treatment. Potential studies to meet these objectives include 1) a novel therapeutic intervention for methamphetamine use disorder; 2) development of machine learning algorithms in the electronic health record to target substance use screening and enhance substance use disorder diagnoses; 3) precision/personalized medicine studies using population pharmacokinetics to better define and refine medication dosing strategies that improve treatment outcome; and 4) testing collaborative care models to address co-occurring chronic medical illnesses in specialty addiction treatment settings. Our expertise spans multi-site clinical trials, implementation science, community-based participatory research, EHR-based interventions, machine learning and natural language processing, and health services research. In addition to community partners that include urban and rural integrated health systems, federally qualified health centers serving underrepresented minorities, specialty addiction treatment programs, and pediatric and adolescent health clinics, the NorthStar Node brings affiliated research and dissemination networks into the CTN, including CTSA, SIREN, PCORNet, JCOIN, HOPE, the Network Coordinating Office of the Addiction Technology Transfer Centers, a learning health system training program (K12), three NIDA training programs (T32), and fellowship programs in addiction medicine and addiction psychiatry. The NorthStar Node is well situated to address current and emerging SUD issues and advance research in the field in order to improve patient outcome and transform health systems.

这项研究是NIH帮助结束长期成瘾（HEAL）计划的一部分，旨在加速科学解决国家阿片类药物公共卫生危机。NIH HEAL倡议支持整个NIH的研究，以改善阿片类药物滥用和成瘾的治疗。自2015年加入NIDA国家药物滥用治疗临床试验网络（CTN）以来，北极星节点为CTN的目标和优先事项做出了重大贡献。北极星节点及其研究人员已经领导或共同领导了五个CTN协议，作为七个CTN研究的研究中心， 担任CTN指导委员会和数据科学工作组主席，在研究发展委员会任职，并为几个特殊兴趣小组做出贡献。北极星节点的研究组合包括传统的随机对照试验（CTN-0068），务实的比较有效性研究（CTN-0098 A和CTN-0099），实施科学（CTN-0074，CTN-0098 B和CTN-0099）， 基于社区的参与性研究（CTN-0096），数据科学（CTN-0076和CTN-0087）和卫生服务研究（CTN-0070）。在此应用中，北极星节点有七个指导目标（POLARIS）：1）生成通知政策和临床指南的证据; 2）评估解决共同SUD和医疗及精神疾病的模型; 3）使用学习健康的原则 系统进行务实的试验; 4）使用人工智能和其他数据科学方法来加强SUD研究和护理; 5）接触研究不足的人群，以确保SUD研究与不同人群相关; 6）使用实施科学来测试循证SUD实践与一般医疗环境的整合;以及7）测试SUD治疗的创新策略。实现这些目标的潜在研究包括：1）针对甲基苯丙胺使用障碍的新型治疗干预; 2）在电子健康记录中开发机器学习算法，以针对物质使用筛查并增强物质使用障碍诊断; 3）使用人群的精确/个性化医学研究 药代动力学，以更好地定义和完善改善治疗结果的药物给药策略;以及4）测试协作护理模式，以解决专业成瘾治疗环境中共同发生的慢性医学疾病。我们的专业知识涵盖多地点临床试验，实施科学，基于社区的参与性研究，基于EHR的干预措施，机器学习和自然语言处理以及卫生服务研究。除了社区合作伙伴，包括城市和农村综合卫生系统，联邦合格的卫生中心服务代表性不足的少数民族，专业成瘾治疗计划，以及儿科和青少年健康诊所，北极星节点带来了附属的研究和 该网络包括CTSA、SIREN、PCORNet、JCOIN、HOPE、成瘾技术转移中心网络协调办公室、学习健康系统培训方案（K12）、三个NIDA培训方案（T32）以及成瘾医学和成瘾精神病学研究金方案。北极星节点处于有利地位，以解决当前和新出现的SUD问题，并推进该领域的研究，以改善患者的治疗效果和改变卫生系统。