Intracranial multimodal physiological monitoring in acute brain injury
急性脑损伤的颅内多模态生理监测
基本信息
- 批准号:10675428
- 负责人:
- 金额:$ 165.81万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-15 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:Acute Brain InjuriesAgeAlgorithmsBiologicalBiomedical EngineeringBloodBlood PressureBrainBrain HypoxiaBrain InjuriesCaringCephalicCerebrumClinicalComplexCoupledCritical IllnessCustomDataData AnalysesData DisplayDevelopmentDevicesDiagnostic EquipmentDiameterElectrodesElectroencephalographyElectronicsEngineeringEvaluationFailureFunctional disorderGoalsHeart RateHemorrhageHomeostasisHumanIncidenceIndividualInfectionInjuryIntensive Care UnitsIntracranial PressureMarketingMathematicsMeasurementMeasuresMetabolicMetabolismMilitary PersonnelModalityMonitorNervous System TraumaNeurologicOutputOxygenPatient CarePatient riskPatient-Focused OutcomesPatientsPersonsPhasePhysiciansPhysiologic MonitoringPhysiologicalPhysiologyPilot ProjectsProviderPublic HealthPulse OximetryRiskSafetyScalp structureSeizuresSignal TransductionSourceStreamSurvivorsSystemSystemic blood pressureTBI PatientsTBI treatmentTabletsTechnologyTemperatureTestingTimeTrainingTranslatingTraumaTraumatic Brain InjuryUniversitiesVendorVisualizationbench to bedsidebrain parenchymabrain tissueclinical examinationcohortcomputerized data processingcostdata acquisitiondata exchangedata integrationdata streamsdigitaldisabilityfabricationflexibilityhealth economicsimplantable deviceimprovedimproved outcomein vivoindividualized medicineinnovationinstrumentationinterestmortalitymultidisciplinarymultimodal datamultimodalityneural implantneurophysiologyneurosurgerypersonalized carepersonalized medicinepopulation basedpressurepreventsafety assessmentsafety testingsensorsocioeconomicssoftware systemstechnology developmenttransmission processtrauma centersusabilitywounded soldieryoung adult
项目摘要
PROJECT SUMMARY
Present day multimodal monitoring for traumatic brain injury (TBI) is limited in its implementation as it
necessitates multiple invasive probes to measure intracranial pressure (ICP), intracranial EEG (icEEG),
intracranial temperature (icT), and brain tissue oxygen (PBTO2), the majority of which require their own
instrumentation and monitors. While there is increasing evidence to support multimodal monitoring in TBI and
other acute brain injuries, the present cumbersome systems make it nearly impossible to use outside of major
Level 1 trauma centers. The challenges include the need for expertise with both probe placement and data
interpretation as well as the integration of multiple electronic units from different vendors with diverse software
systems, each requiring training, IT and biomedical engineering support. Coupled with this is an increased risk
of bleeding and infection from the multiple entry points into brain parenchyma. Our objective is to develop a
single source brain monitoring solution for the management of severe TBI. We will integrate the modalities
indicated for severe TBI (ICP, icEEG, icT, PBTO2) in a brain implantable device called the NeuroProbe with a
target diameter which is equivalent to, or smaller than, individual current probes. We will develop a single
interface device called the NeuroLink to acquire the multi-modal intracranial data from the NeuroProbe as well
as scalp EEG and patient physiological data including systemic blood pressure (SBP), heart rate (HR), mean
arterial pressure (MAP) and blood oxygen (SpO2) and transmit these sensor signals to monitors as a time-
locked single digital data stream. We will develop a display unit called the NeuroMonitor to analyze and display
the acquired multimodal data in a synchronized real-time manner. We call the composite solution created by
the NeuroProbe, NeuroLink, and NeuroMonitor devices the NeuroProbe Solution. The technological
development of the NeuroProbe Solution dramatically expands the capabilities of the existing icEEG depth
electrodes developed at Yale University and multimodal probes currently on the market. The key innovations of
the NeuroProbe Solution are:
1. Integration of multiple physiologic sensors on a single intracranial probe (NeuroProbe).
2. Simplification of NeuroProbe to allow placement at bedside in a civilian or military facility.
3. Development of a multimodal interface device (NeuroLink) to store and relay time-locked digital data
acquired from the NeuroProbe and extracranial sensors to the NeuroMonitor and other clinical monitors.
4. Development of an iPad sized monitor (NeuroMonitor) to analyze and display multimodal data.
5. Time-locked multi-stream data transfer which allows for real-time and post-hoc data review and analysis.
This innovative solution allows acquisition and integration of data from multiple physiological parameters
through a standard small tablet creating a simple single end-to-end solution from sensors to multimodal data
analysis and display in an otherwise fragmented and complex domain.
项目摘要
目前,创伤性脑损伤(TBI)的多模式监测在其实施方面受到限制,因为它
需要多个侵入式探头来测量颅内压(ICP)、颅内EEG(icEEG),
颅内温度(icT)和脑组织氧(PBTO 2),其中大多数需要自己的
仪器和监视器。虽然有越来越多的证据支持TBI的多模式监测,
其他急性脑损伤,目前繁琐的系统,使它几乎不可能使用以外的主要
一级创伤中心。挑战包括需要探针放置和数据方面的专业知识
解释以及来自不同供应商的多个电子单元与不同软件的集成
系统,每个都需要培训,IT和生物医学工程支持。再加上这是一个风险增加
出血和感染从多处进入脑实质我们的目标是发展一个
用于严重TBI管理的单一来源脑监测解决方案。我们将整合各种模式,
适用于严重TBI(ICP,icEEG,icT,PBTO 2),在称为NeuroProbe的大脑植入式设备中,
目标直径等于或小于单个电流探针。我们将开发一个单一的
称为NeuroLink的接口设备也可从NeuroProbe采集多模态颅内数据
作为头皮EEG和患者生理数据,包括全身血压(SBP)、心率(HR)、平均
动脉压(MAP)和血氧(SpO2),并将这些传感器信号作为时间传输到监护仪。
锁定的单个数字数据流。我们将开发一个名为NeuroMonitor的显示单元来分析和显示
以同步的实时方式获取多模态数据。我们称之为由
NeuroProbe、NeuroLink和NeuroMonitor器械NeuroProbe解决方案。技术
NeuroProbe解决方案的开发极大地扩展了现有icEEG深度的能力,
耶鲁大学开发的电极和目前市场上的多模式探针。的关键创新
NeuroProbe解决方案包括:
1.在单个颅内探头(NeuroProbe)上集成多个生理传感器。
2.简化NeuroProbe,允许放置在民用或军用设施的床边。
3.开发多模式接口设备(NeuroLink),以存储和中继时间锁定的数字数据
从NeuroProbe和颅外传感器采集的数据传输到NeuroMonitor和其他临床监护仪。
4.开发iPad大小的监视器(NeuroMonitor),用于分析和显示多模态数据。
5.时间锁定的多流数据传输,允许实时和事后数据审查和分析。
这种创新的解决方案允许采集和整合来自多个生理参数的数据
通过一个标准的小平板电脑创建一个简单的从传感器到多模式数据的端到端解决方案
在分散且复杂的领域中进行分析和显示。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
STEVEN J SCHIFF其他文献
STEVEN J SCHIFF的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('STEVEN J SCHIFF', 18)}}的其他基金
Intracranial multimodal physiological monitoring in acute brain injury
急性脑损伤的颅内多模态生理监测
- 批准号:
10291003 - 财政年份:2022
- 资助金额:
$ 165.81万 - 项目类别:
Predictive Personalized Public Health (P3H): A Novel Paradigm to Treat Infectious Disease
预测性个性化公共卫生(P3H):治疗传染病的新范式
- 批准号:
10241253 - 财政年份:2018
- 资助金额:
$ 165.81万 - 项目类别:
Predictive Personalized Public Health (P3H): A Novel Paradigm to Treat Infectious Disease
预测性个性化公共卫生(P3H):治疗传染病的新范式
- 批准号:
10006784 - 财政年份:2018
- 资助金额:
$ 165.81万 - 项目类别:
Predictive Personalized Public Health (P3H): A Novel Paradigm to Treat Infectious Disease
预测性个性化公共卫生(P3H):治疗传染病的新范式
- 批准号:
10699327 - 财政年份:2018
- 资助金额:
$ 165.81万 - 项目类别:
Control of the Neonatal Septisome and Hydrocephalus in sub-Saharan Africa
撒哈拉以南非洲地区新生儿败血症和脑积水的控制
- 批准号:
8754244 - 财政年份:2015
- 资助金额:
$ 165.81万 - 项目类别:
Innovations at the Intersection of Neural Engineering, Materials Sci & Medicine
神经工程、材料科学交叉点的创新
- 批准号:
7856458 - 财政年份:2009
- 资助金额:
$ 165.81万 - 项目类别:
Innovations at the Intersection of Neural Engineering, Materials Sci & Medicine
神经工程、材料科学交叉点的创新
- 批准号:
7941719 - 财政年份:2009
- 资助金额:
$ 165.81万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政策的情绪动态
- 批准号:
10108433 - 财政年份:2024
- 资助金额:
$ 165.81万 - 项目类别:
EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
- 批准号:
MR/X032809/1 - 财政年份:2024
- 资助金额:
$ 165.81万 - 项目类别:
Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
- 批准号:
MR/X034690/1 - 财政年份:2024
- 资助金额:
$ 165.81万 - 项目类别:
Fellowship
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341426 - 财政年份:2024
- 资助金额:
$ 165.81万 - 项目类别:
Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341424 - 财政年份:2024
- 资助金额:
$ 165.81万 - 项目类别:
Continuing Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
- 批准号:
2335955 - 财政年份:2024
- 资助金额:
$ 165.81万 - 项目类别:
Standard Grant
The economics of (mis)information in the age of social media
社交媒体时代(错误)信息的经济学
- 批准号:
DP240103257 - 财政年份:2024
- 资助金额:
$ 165.81万 - 项目类别:
Discovery Projects
How age & sex impact the transcriptional control of mammalian muscle growth
你多大
- 批准号:
DP240100408 - 财政年份:2024
- 资助金额:
$ 165.81万 - 项目类别:
Discovery Projects
Supporting teachers and teaching in the age of Artificial Intelligence
支持人工智能时代的教师和教学
- 批准号:
DP240100111 - 财政年份:2024
- 资助金额:
$ 165.81万 - 项目类别:
Discovery Projects
Enhancing Wahkohtowin (Kinship beyond the immediate family) Community-based models of care to reach and support Indigenous and racialized women of reproductive age and pregnant women in Canada for the prevention of congenital syphilis
加强 Wahkohtowin(直系亲属以外的亲属关系)以社区为基础的护理模式,以接触和支持加拿大的土著和种族育龄妇女以及孕妇,预防先天梅毒
- 批准号:
502786 - 财政年份:2024
- 资助金额:
$ 165.81万 - 项目类别:
Directed Grant