Fetal ethanol-induced behavioral deficits: Mechanisms, diagnoses and intervention

胎儿乙醇引起的行为缺陷：机制、诊断和干预

• 批准号: 10674485
• 负责人: Daniel D. Savage
• 金额: $ 148.23万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10674485
• 关键词: Acceleration; Achievement; Address; Advisory Committees; Affect; Alcohols; Area; Award; Behavioral; Biochemical; Biological Markers; Brain Injuries; Child; Cities; Clinical; Clinical Sciences; Communication; Community Outreach; Complement; Development; Diagnosis; Education; Ensure; Environment; Ethanol; Faculty; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal alcohol effects; Fetus; Foundations; Goals; Grant; Health Sciences; Individual; International; Intervention; Investigation; Knowledge; Leadership; Life; Mentors; Methods; National Institute on Alcohol Abuse and Alcoholism; New Mexico; Patients; Phase; Philosophy; Physiological; Pilot Projects; Problem behavior; Procedures; Recording of previous events; Research; Research Activity; Research Personnel; Risk; Scientist; Series; Training; Training Programs; Translational Research; Universities; Work; alcohol consumption during pregnancy; alcohol exposure; alcohol research; biobehavior; clinical investigation; diagnostic biomarker; effective intervention; efficacy evaluation; faculty mentor; fetal; graduate student; laboratory experience; meetings; neurobehavioral; neurobiological mechanism; novel; pre-clinical; prenatal; prenatal intervention; prognostic; programs; recruit; symposium; synergism; tool; undergraduate student; web page

PROJECT SUMMARY - OVERALL NMARC is a NIAAA-designated Alcohol Research P50 Center at the UNM Health Sciences Center. The center is comprised of teams of preclinical and clinical scientists with a history of collaborative research interactions whose expertise and contributions have synergized the center’s research environment and is facilitating progress towards the achievement of NMARC’s three strategic objectives. These strategic objectives are to: 1) Advance our understanding of how prenatal alcohol exposure affects basic neurobiological mechanisms resulting in functional brain damage which can lead to life-long adverse neurobehavioral consequences. 2) Develop more effective approaches for the diagnosis of individuals with FASD through the establishment of more sensitive and clinically reliable biochemical, physiological and neurobehavioral biomarkers of alcohol exposure that are detectible early in life, are prognostic of functional brain damage, and could predict long-lasting neurobehavioral consequences in patients with FASD. 3) Develop interventions that are more effective for prenatal alcohol- related behavioral deficits. Better interventions may ultimately require combinations of neurobehavioral, educational and/or pharmacotherapeutic approaches to ameliorate the often subtle, but long-lasting impact of prenatal alcohol-induced behavioral problems. NMARC’s prevailing philosophy is that a research center organized to maximize the coordination, communication and synergistic integration across multiple lines of preclinical and clinical investigation in these three strategic objective areas provides the best long-term prospect of achieving significant progress towards the dual clinical goals of better diagnosis and more effective interventions for patients with FASD. NMARC’s specific aims as an integrated whole during the P50 Phase II will continue to be to: 1) Accelerate progress on each on NMARC’s three strategic objectives. 2) Catalyze the expansion of NMARC’s research capacity and capabilities. 3) Enhance our capability to disseminate knowledge about FASD through seminars, symposia and community outreach activities. 4) Increase the number of undergraduate and graduate students, fellows and residents training in the FASD research field. This P50 competing renewal contains four research components, each consisting of teams of investigators whose projects address one or more of NMARC’s three strategic objectives. Two core components support the center’s research program: 1) A Pilot Project Core with two two-year projects involving faculty investigators new to the FASD research field. 2) An Administrative Core that provides scientific and administrative leadership for the entire NMARC program, along with administrative support and budgetary oversight of all NMARC-related activities. The Administrative Core is also responsible for ensuring progress toward achieving the specific aims of the center as a whole. Assessment of NMARC’s progress towards the achievement of these aims and the strategic objectives is the responsibility of the Executive and Steering Committees working in conjunction with our external Program Advisory Committee comprised of seven internationally renowned FASD scientists.

项目概要-总体 NMARC是UNM健康科学中心的NIAAA指定酒精研究P50中心。中心 由临床前和临床科学家组成的团队，具有合作研究互动的历史 他们的专业知识和贡献协同中心的研究环境， 实现了NMARC的三大战略目标。这些战略目标是：（1）推进 我们对产前酒精暴露如何影响基本神经生物学机制的理解， 功能性脑损伤，可能导致终身不良神经行为后果。2)开发更多 通过建立更敏感和更有效的方法来诊断FASD患者， 酒精暴露的临床可靠的生化，生理和神经行为生物标志物， 可在生命早期检测到，是功能性脑损伤的预后，并可预测长期的神经行为 FASD患者的后果。3)开发对产前酒精更有效的干预措施- 相关的行为缺陷。更好的干预措施最终可能需要神经行为， 教育和/或药物治疗方法，以改善往往微妙的，但长期的影响， 产前酒精诱发的行为问题NMARC的主流理念是， 组织起来，最大限度地加强多方面的协调、沟通和协同一体化， 这三个战略目标领域的临床前和临床研究提供了最佳的长期前景 实现更好的诊断和更有效的双重临床目标的重大进展 对FASD患者进行干预。NMARC在P50第二阶段作为一个整体的具体目标 将继续：1）加快NMARC三个战略目标的进展。2)催化 扩大NMARC的研究能力和能力。3)提高我们传播知识的能力 通过研讨会、专题讨论会和社区外展活动，宣传FASD。4)使更多的 本科生和研究生，研究员和居民培训在FASD研究领域。P50 竞争性更新包括四个研究部分，每个部分由研究人员组成，他们的项目 实现NMARC三大战略目标中的一个或多个。两个核心组件支持该中心的 研究计划：1）一个试点项目的核心，有两个为期两年的项目，涉及教师调查新的 FASD研究领域。2)一个行政核心，提供科学和行政领导， 整个NMARC程序，沿着所有与NMARC相关的行政支持和预算监督 活动行政核心还负责确保实现具体目标的进展 中心作为一个整体。评估NMARC在实现这些目标方面取得的进展， 战略目标是执行委员会和指导委员会的责任， 我们的外部项目咨询委员会由七位国际知名的FASD科学家组成。

项目成果

Covariation Between Brain Function (MEG) and Structure (DTI) Differentiates Adolescents with Fetal Alcohol Spectrum Disorder from Typically Developing Controls.

• DOI: 10.1016/j.neuroscience.2020.09.053
• 发表时间: 2020-11-21
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: Pinner JFL;Coffman BA;Stephen JM
• 通讯作者: Stephen JM

Prenatal alcohol exposure alters p35, CDK5 and GSK3β in the medial frontal cortex and hippocampus of adolescent mice.

• DOI: 10.1016/j.toxrep.2014.08.005
• 发表时间: 2014
• 期刊: TOXICOLOGY REPORTS
• 作者: Goggin, Samantha L;Caldwell, Kevin K;Cunningham, Lee Anna;Allan, Andrea M
• 通讯作者: Allan, Andrea M

Low concentrations of alcohol inhibit BDNF-dependent GABAergic plasticity via L-type Ca2+ channel inhibition in developing CA3 hippocampal pyramidal neurons.

• DOI: 10.1523/jneurosci.5405-09.2010
• 发表时间: 2010-05-12
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Zucca S;Valenzuela CF
• 通讯作者: Valenzuela CF

Effects of spinal non-viral interleukin-10 gene therapy formulated with d-mannose in neuropathic interleukin-10 deficient mice: Behavioral characterization, mRNA and protein analysis in pain relevant tissues.

• DOI: 10.1016/j.bbi.2017.11.004
• 发表时间: 2018-03
• 期刊: Brain, behavior, and immunity
• 作者: Vanderwall AG;Noor S;Sun MS;Sanchez JE;Yang XO;Jantzie LL;Mellios N;Milligan ED
• 通讯作者: Milligan ED

Disrupted dynamic functional network connectivity in fetal alcohol spectrum disorders.

胎儿酒精谱系障碍的动态功能网络连接中断。

• DOI: 10.1111/acer.15046
• 发表时间: 2023
• 期刊: Alcohol, clinical & experimental research
• 作者: Candelaria-Cook,FelichaT;Schendel,MeganE;Flynn,Lucinda;Cerros,Cassandra;Hill,DinaE;Stephen,JuliaM
• 通讯作者: Stephen,JuliaM