Fetal ethanol-induced behavioral deficits: Mechanisms, diagnoses and intervention

项目总结--总体 NMARC是新墨西哥州大学健康科学中心的NIAAA指定的酒精研究P50中心。中心 是由具有合作研究互动历史的临床前和临床科学家组成的团队 他们的专业知识和贡献协同了该中心的研究环境，并正在推动进展 实现NMARC的三个战略目标。这些战略目标是：1)推进 我们对产前酒精暴露如何影响基本神经生物学机制的理解 功能性脑损伤，可能导致终生不良的神经行为后果。2)发展更多 通过建立更敏感和更有效的方法来诊断FASD患者 酒精暴露的临床可靠的生化、生理和神经行为生物标记物 在生命早期就可以检测到，是功能性脑损伤的预测，并可以预测长期的神经行为 FASD患者的后果。3)制定对产前饮酒更有效的干预措施- 相关的行为缺陷。更好的干预最终可能需要神经行为、 教育和/或药物治疗方法，以改善通常微妙但长期的影响 产前饮酒导致的行为问题。NMARC的主流理念是，一个研究中心 组织以最大限度地提高协调、沟通和协同集成的能力 这三个战略目标领域的临床前和临床研究提供了最好的长期前景 朝着更好的诊断和更有效的双重临床目标取得重大进展 FASD患者的干预措施。NMARC在P50第二阶段作为一个整体的具体目标 将继续：1)加快NMARC三个战略目标的进展。2)催化 扩大NMARC的研究能力和能力。3)增强传播知识的能力 通过研讨会、座谈会和社区外展活动了解FASD。4)增加 FASD研究领域的本科生、研究生、研究员和住院医师培训。本页第50页 竞争性更新包含四个研究部分，每个部分由研究人员团队组成，他们的项目 实现NMARC的三个战略目标中的一个或多个。两个核心组件支持该中心的 研究计划：1)一个试点项目核心，有两个为期两年的项目，由新加入的教员调查人员参与 FASD研究领域。2)提供科学和行政领导的行政核心 整个NMARC计划，以及所有与NMARC相关的行政支持和预算监督 活动。行政核心还负责确保在实现具体目标方面取得进展 作为一个整体的中心。评估NMARC在实现这些目标方面取得的进展以及 战略目标是执行委员会和指导委员会共同努力的责任 我们的外部计划咨询委员会由七名国际知名的FASD科学家组成。

PROJECT SUMMARY - OVERALL NMARC is a NIAAA-designated Alcohol Research P50 Center at the UNM Health Sciences Center. The center is comprised of teams of preclinical and clinical scientists with a history of collaborative research interactions whose expertise and contributions have synergized the center’s research environment and is facilitating progress towards the achievement of NMARC’s three strategic objectives. These strategic objectives are to: 1) Advance our understanding of how prenatal alcohol exposure affects basic neurobiological mechanisms resulting in functional brain damage which can lead to life-long adverse neurobehavioral consequences. 2) Develop more effective approaches for the diagnosis of individuals with FASD through the establishment of more sensitive and clinically reliable biochemical, physiological and neurobehavioral biomarkers of alcohol exposure that are detectible early in life, are prognostic of functional brain damage, and could predict long-lasting neurobehavioral consequences in patients with FASD. 3) Develop interventions that are more effective for prenatal alcohol- related behavioral deficits. Better interventions may ultimately require combinations of neurobehavioral, educational and/or pharmacotherapeutic approaches to ameliorate the often subtle, but long-lasting impact of prenatal alcohol-induced behavioral problems. NMARC’s prevailing philosophy is that a research center organized to maximize the coordination, communication and synergistic integration across multiple lines of preclinical and clinical investigation in these three strategic objective areas provides the best long-term prospect of achieving significant progress towards the dual clinical goals of better diagnosis and more effective interventions for patients with FASD. NMARC’s specific aims as an integrated whole during the P50 Phase II will continue to be to: 1) Accelerate progress on each on NMARC’s three strategic objectives. 2) Catalyze the expansion of NMARC’s research capacity and capabilities. 3) Enhance our capability to disseminate knowledge about FASD through seminars, symposia and community outreach activities. 4) Increase the number of undergraduate and graduate students, fellows and residents training in the FASD research field. This P50 competing renewal contains four research components, each consisting of teams of investigators whose projects address one or more of NMARC’s three strategic objectives. Two core components support the center’s research program: 1) A Pilot Project Core with two two-year projects involving faculty investigators new to the FASD research field. 2) An Administrative Core that provides scientific and administrative leadership for the entire NMARC program, along with administrative support and budgetary oversight of all NMARC-related activities. The Administrative Core is also responsible for ensuring progress toward achieving the specific aims of the center as a whole. Assessment of NMARC’s progress towards the achievement of these aims and the strategic objectives is the responsibility of the Executive and Steering Committees working in conjunction with our external Program Advisory Committee comprised of seven internationally renowned FASD scientists.