Fetal ethanol-induced behavioral deficits: Mechanisms, diagnosis and Intervention

描述（由申请人提供）：NMARC是UNM健康科学中心的NIAAA指定的发展酒精研究P20中心。该中心由临床前和临床科学家团队组成，他们有着合作研究互动的历史，他们的专业知识和贡献协同了中心的研究环境，并促进了NMARC三大战略目标的实现。这些目标是：1）推进我们对胎儿酒精暴露的致畸后果的理解，这种致畸后果会导致功能性脑损伤，从而导致不良的神经行为结果。2)开发更有效的方法，通过建立更敏感和可靠的酒精暴露的酒精生物标志物，结合使用新的神经行为和功能性神经成像评估，可以在生命早期检测功能性脑损伤，来诊断FASD患者。3)为胎儿酒精相关行为缺陷制定更有效的神经行为、教育和药物干预措施。NMARC的主要理念是，组织研究中心，以最大限度地提高临床前和临床研究的多个领域的协调、沟通和协同整合，为实现FASD更好诊断和更有效干预的双重临床目标提供最佳长期前景。这个P50补助金申请包含五个研究部分，每个部分由研究人员组成，其项目涉及NMARC三个战略目标中的一个或多个。三个核心组成部分支持该中心的研究计划：1）试点项目核心与一个临床和两个临床前项目由新的研究人员领导的FASD研究领域。2)一个科学核心，支持所有NMARC调查人员，并作为一个论坛，促进合作和同行小组辅导。3)一个行政核心，将提供科学和行政领导的整个NMARC计划沿着行政支持和预算监督的中心计划。行政核心还将负责确保通过招聘其他UNM教师和新教师来实现中心建设研究能力的目标，并提高我们的知识传播能力。NMARC的进展和成就的评估将是指导委员会的责任，该委员会将与由七位国际知名的FASD科学家组成的外部计划咨询委员会合作，他们将为NMARC的研究活动和实现中心目标和战略目标的进展提供建议和评估。

DESCRIPTION (provided by applicant): NMARC is a NIAAA-designated Developmental Alcohol Research P20 Center at the UNM Health Sciences Center. The center is comprised of teams of preclinical and clinical scientists with a history of collaborative research interactions whose expertise and contributions have synergized the center's research environment and is facilitating progress towards the achievement of NMARC's three strategic objectives. These objectives are to: 1) Advance our understanding of the teratogenic consequences of fetal alcohol exposure that cause functional brain damage leading to adverse neurobehavioral outcomes. 2) Develop more effective approaches for diagnosing individuals with FASD through the establishment of more sensitive and reliable alcohol biomarkers of alcohol exposure coupled with the use of novel neurobehavioral and functional neuroimaging assessments that can detect functional brain damage earlier in life. 3) Develop more effective neurobehavioral, educational and pharmacotherapeutic interventions tor fetal alcohol-related behavioral deficits. NMARC's prevailing philosophy is that a research center organized to maximize the coordination, communication and synergistic integration across multiple lines of preclinical and clinical investigation provides the best long-term prospect of achieving significant progress towards the dual clinical goals of better diagnosis and more effective interventions for FASD. This P50 grant application contains five research components, each consisting of teams of investigators whose project addresses one or more of NMARC's three strategic objectives. Three core components support the center's research program: 1) A Pilot Project Core with one clinical and two preclinical projects led by investigators new to the FASD research field. 2) A Science Core that supports all NMARC investigators and serves as a forum for catalyzing collaboration and peer group mentoring. 3) An Administrative Core that will provide scientific and administrative leadership for the entire NMARC program along with administrative support and budgetary oversight of the center programs. The Administrative Core will also be responsible for ensuring progress toward achieving the center's goals of building research capacity through the recruitment of other UNM faculty and new faculty hires, and enhancing our knowledge dissemination capabilities. Assessment of NMARC's progress and achievements will be the responsibility of the Steering Committee working in conjunction with an external Program Advisory Committee of seven internationally-renowned FASD scientists, who will advise and assess NMARC's research activities and progress towards the achievement of the center's goals and strategic objectives.