Fetal ethanol-induced behavioral deficits: Mechanisms, diagnosis and Intervention

描述（由申请人提供）：NMARC是niaaa指定的新墨西哥大学健康科学中心的发展酒精研究P20中心。该中心由具有合作研究互动历史的临床前和临床科学家团队组成，他们的专业知识和贡献协同了中心的研究环境，并促进了NMARC三大战略目标的实现。这些目标是：1)提高我们对胎儿酒精暴露导致功能性脑损伤导致不良神经行为结果的致畸后果的理解。2)通过建立更敏感和可靠的酒精暴露酒精生物标志物，结合使用新的神经行为和功能神经影像学评估，开发更有效的方法来诊断FASD患者，这些评估可以在生命早期检测功能性脑损伤。3)针对胎儿酒精相关行为缺陷制定更有效的神经行为、教育和药物治疗干预措施。NMARC的主要理念是建立一个研究中心，最大限度地协调、沟通和协同整合临床前和临床研究的多个线，为实现更好的诊断和更有效的干预FASD的双重临床目标取得重大进展提供最佳的长期前景。这项P50拨款申请包括五个研究部分，每个研究部分由研究小组组成，研究小组的项目涉及NMARC的三个战略目标中的一个或多个。三个核心组成部分支持该中心的研究计划：1)一个试点项目核心，由FASD研究领域的新研究者领导一个临床和两个临床前项目。2)支持所有NMARC研究人员的科学核心，并作为促进合作和同伴小组指导的论坛。3)行政核心将为整个NMARC项目提供科学和行政领导，并为中心项目提供行政支持和预算监督。行政核心还将负责确保中心通过招聘其他新墨西哥大学教师和新教师来实现建立研究能力的目标，并提高我们的知识传播能力。评估NMARC的进展和成就将由指导委员会负责，并与由7名国际知名的FASD科学家组成的外部项目咨询委员会合作，他们将为NMARC的研究活动和实现中心目标和战略目标的进展提供建议和评估。

DESCRIPTION (provided by applicant): NMARC is a NIAAA-designated Developmental Alcohol Research P20 Center at the UNM Health Sciences Center. The center is comprised of teams of preclinical and clinical scientists with a history of collaborative research interactions whose expertise and contributions have synergized the center's research environment and is facilitating progress towards the achievement of NMARC's three strategic objectives. These objectives are to: 1) Advance our understanding of the teratogenic consequences of fetal alcohol exposure that cause functional brain damage leading to adverse neurobehavioral outcomes. 2) Develop more effective approaches for diagnosing individuals with FASD through the establishment of more sensitive and reliable alcohol biomarkers of alcohol exposure coupled with the use of novel neurobehavioral and functional neuroimaging assessments that can detect functional brain damage earlier in life. 3) Develop more effective neurobehavioral, educational and pharmacotherapeutic interventions tor fetal alcohol-related behavioral deficits. NMARC's prevailing philosophy is that a research center organized to maximize the coordination, communication and synergistic integration across multiple lines of preclinical and clinical investigation provides the best long-term prospect of achieving significant progress towards the dual clinical goals of better diagnosis and more effective interventions for FASD. This P50 grant application contains five research components, each consisting of teams of investigators whose project addresses one or more of NMARC's three strategic objectives. Three core components support the center's research program: 1) A Pilot Project Core with one clinical and two preclinical projects led by investigators new to the FASD research field. 2) A Science Core that supports all NMARC investigators and serves as a forum for catalyzing collaboration and peer group mentoring. 3) An Administrative Core that will provide scientific and administrative leadership for the entire NMARC program along with administrative support and budgetary oversight of the center programs. The Administrative Core will also be responsible for ensuring progress toward achieving the center's goals of building research capacity through the recruitment of other UNM faculty and new faculty hires, and enhancing our knowledge dissemination capabilities. Assessment of NMARC's progress and achievements will be the responsibility of the Steering Committee working in conjunction with an external Program Advisory Committee of seven internationally-renowned FASD scientists, who will advise and assess NMARC's research activities and progress towards the achievement of the center's goals and strategic objectives.