Fetal ethanol-induced behavioral deficits: Mechanisms, diagnosis and Intervention

描述(由申请者提供)：NMARC是由NIAAA指定的位于UNM健康科学中心的发育酒精研究P20中心。该中心由具有合作研究互动历史的临床前和临床科学家团队组成，他们的专业知识和贡献协同了该中心的研究环境，并正在推动实现NMARC的三个战略目标。这些目标是：1)促进我们对胎儿酒精暴露的致畸后果的理解，胎儿酒精暴露会导致功能性脑损伤，从而导致不良的神经行为后果。2)开发更有效的方法来诊断FASD患者，方法是建立更敏感和可靠的酒精暴露生物标志物，并使用新的神经行为和功能神经成像评估，可以在生命的早期发现功能性脑损伤。3)针对胎儿酒精相关行为缺陷，开发更有效的神经行为、教育和药物治疗干预措施。NMARC的主流理念是，组织一个研究中心，以最大限度地协调、沟通和协同整合多条临床前和临床研究路线，为实现FASD更好的诊断和更有效的干预这两个临床目标提供最好的长期前景。这份P50拨款申请包含五个研究部分，每个部分都由调查人员团队组成，他们的项目涉及NMARC三个战略目标中的一个或多个。三个核心组成部分支持该中心的研究计划：1)一个试点项目核心，包括一个临床项目和两个临床前项目，由FASD研究领域的新手领导。2)支持所有NMARC研究人员的科学核心，并作为催化合作和同龄人小组指导的论坛。3)一个行政核心，将为整个NMARC项目提供科学和行政领导，以及对中心项目的行政支持和预算监督。行政核心还将负责确保在实现中心通过招聘其他UNM教员和新聘教员来建设研究能力的目标方面取得进展，并增强我们的知识传播能力。对NMARC的进展和成就的评估将由指导委员会与一个由七位国际知名FASD科学家组成的外部计划咨询委员会共同负责，该委员会将为NMARC的研究活动和实现中心目标和战略目标的进展提供建议和评估。

DESCRIPTION (provided by applicant): NMARC is a NIAAA-designated Developmental Alcohol Research P20 Center at the UNM Health Sciences Center. The center is comprised of teams of preclinical and clinical scientists with a history of collaborative research interactions whose expertise and contributions have synergized the center's research environment and is facilitating progress towards the achievement of NMARC's three strategic objectives. These objectives are to: 1) Advance our understanding of the teratogenic consequences of fetal alcohol exposure that cause functional brain damage leading to adverse neurobehavioral outcomes. 2) Develop more effective approaches for diagnosing individuals with FASD through the establishment of more sensitive and reliable alcohol biomarkers of alcohol exposure coupled with the use of novel neurobehavioral and functional neuroimaging assessments that can detect functional brain damage earlier in life. 3) Develop more effective neurobehavioral, educational and pharmacotherapeutic interventions tor fetal alcohol-related behavioral deficits. NMARC's prevailing philosophy is that a research center organized to maximize the coordination, communication and synergistic integration across multiple lines of preclinical and clinical investigation provides the best long-term prospect of achieving significant progress towards the dual clinical goals of better diagnosis and more effective interventions for FASD. This P50 grant application contains five research components, each consisting of teams of investigators whose project addresses one or more of NMARC's three strategic objectives. Three core components support the center's research program: 1) A Pilot Project Core with one clinical and two preclinical projects led by investigators new to the FASD research field. 2) A Science Core that supports all NMARC investigators and serves as a forum for catalyzing collaboration and peer group mentoring. 3) An Administrative Core that will provide scientific and administrative leadership for the entire NMARC program along with administrative support and budgetary oversight of the center programs. The Administrative Core will also be responsible for ensuring progress toward achieving the center's goals of building research capacity through the recruitment of other UNM faculty and new faculty hires, and enhancing our knowledge dissemination capabilities. Assessment of NMARC's progress and achievements will be the responsibility of the Steering Committee working in conjunction with an external Program Advisory Committee of seven internationally-renowned FASD scientists, who will advise and assess NMARC's research activities and progress towards the achievement of the center's goals and strategic objectives.