Fetal ethanol-induced behavioral deficits: Mechanisms, diagnosis and Intervention
胎儿乙醇引起的行为缺陷:机制、诊断和干预
基本信息
- 批准号:9242967
- 负责人:
- 金额:$ 6.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-08-05 至 2018-06-30
- 项目状态:已结题
- 来源:
- 关键词:AchievementAddressAdvisory CommitteesAffectAlcoholsApplications GrantsAreaAwardBehavioralBiological MarkersBrainBrain InjuriesChildCitiesClinicalClinical SciencesCollaborationsCommunicationCommunity OutreachComplementCoupledDevelopmentDiagnosisEnsureEnvironmentEthanolFacultyFetal Alcohol ExposureFetal Alcohol Spectrum DisorderFetal alcohol effectsFetusGoalsGrantHealthHealth SciencesIndividualInterventionInvestigationKnowledgeLeadLeadershipLifeLightMentorsMethodsNational Institute on Alcohol Abuse and AlcoholismNew MexicoOutcomePeer GroupPhasePhilosophyPilot ProjectsProceduresRecording of previous eventsResearchResearch ActivityResearch PersonnelRiskScienceScientistSeriesTNFRSF5 geneTrainingTraining ProgramsTranslational ResearchUniversitiesWorkalcohol consumption during pregnancyalcohol exposurealcohol researchclinical investigationdiagnostic biomarkereffective interventionexpectationfaculty mentorfetalgraduate studentlaboratory experiencemeetingsneurobehavioralneurobiological mechanismneuroimagingnovelpre-clinicalprogramssymposiumtoolundergraduate studentweb page
项目摘要
DESCRIPTION (provided by applicant): NMARC is a NIAAA-designated Developmental Alcohol Research P20 Center at the UNM Health Sciences Center. The center is comprised of teams of preclinical and clinical scientists with a history of collaborative research interactions whose expertise and contributions have synergized the center's research environment and is facilitating progress towards the achievement of NMARC's three strategic objectives. These objectives are to: 1) Advance our understanding of the teratogenic consequences of fetal alcohol exposure that cause functional brain damage leading to adverse neurobehavioral outcomes. 2) Develop more effective approaches for diagnosing individuals with FASD through the establishment of more sensitive and reliable alcohol biomarkers of alcohol exposure coupled with the use of novel neurobehavioral and functional neuroimaging assessments that can detect functional brain damage earlier in life. 3) Develop more effective neurobehavioral, educational and pharmacotherapeutic interventions tor fetal alcohol-related behavioral deficits. NMARC's prevailing philosophy is that a research center organized to maximize the coordination, communication and synergistic integration across multiple lines of preclinical and clinical investigation provides the best long-term prospect of achieving significant progress towards the dual clinical goals of better diagnosis and more effective interventions for FASD. This P50 grant application contains five research components, each consisting of teams of investigators whose project addresses one or more of NMARC's three strategic objectives. Three core components support the center's research program: 1) A Pilot Project Core with one clinical and two preclinical projects led by investigators new to the FASD research field. 2) A Science Core that supports all NMARC investigators and serves as a forum for catalyzing collaboration and peer group mentoring. 3) An Administrative Core that will provide scientific and administrative leadership for the entire NMARC program along with administrative support and budgetary oversight of the center programs. The Administrative Core will also be responsible for ensuring progress toward achieving the center's goals of building research capacity through the recruitment of other UNM faculty and new faculty hires, and enhancing our knowledge dissemination capabilities. Assessment of NMARC's progress and achievements will be the responsibility of the Steering Committee working in conjunction with an external Program Advisory Committee of seven internationally-renowned FASD scientists, who will advise and assess NMARC's research activities and progress towards the achievement of the center's goals and strategic objectives.
描述(由申请人提供):NMARC是UNM健康科学中心的NIAAA指定的发展酒精研究P20中心。该中心由临床前和临床科学家团队组成,他们有着合作研究互动的历史,他们的专业知识和贡献协同了中心的研究环境,并促进了NMARC三大战略目标的实现。这些目标是:1)推进我们对胎儿酒精暴露的致畸后果的理解,这种致畸后果会导致功能性脑损伤,从而导致不良的神经行为结果。2)开发更有效的方法,通过建立更敏感和可靠的酒精暴露的酒精生物标志物,结合使用新的神经行为和功能性神经成像评估,可以在生命早期检测功能性脑损伤,来诊断FASD患者。3)为胎儿酒精相关行为缺陷制定更有效的神经行为、教育和药物干预措施。NMARC的主要理念是,组织研究中心,以最大限度地提高临床前和临床研究的多个领域的协调、沟通和协同整合,为实现FASD更好诊断和更有效干预的双重临床目标提供最佳长期前景。这个P50补助金申请包含五个研究部分,每个部分由研究人员组成,其项目涉及NMARC三个战略目标中的一个或多个。三个核心组成部分支持该中心的研究计划:1)试点项目核心与一个临床和两个临床前项目由新的研究人员领导的FASD研究领域。2)一个科学核心,支持所有NMARC调查人员,并作为一个论坛,促进合作和同行小组辅导。3)一个行政核心,将提供科学和行政领导的整个NMARC计划沿着行政支持和预算监督的中心计划。行政核心还将负责确保通过招聘其他UNM教师和新教师来实现中心建设研究能力的目标,并提高我们的知识传播能力。NMARC的进展和成就的评估将是指导委员会的责任,该委员会将与由七位国际知名的FASD科学家组成的外部计划咨询委员会合作,他们将为NMARC的研究活动和实现中心目标和战略目标的进展提供建议和评估。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Daniel D. Savage其他文献
Ionotropic glutamate receptor subunit expression in the rat hippocampus: lack of an effect of a long-term ethanol exposure paradigm.
大鼠海马离子型谷氨酸受体亚基表达:缺乏长期乙醇暴露范例的影响。
- DOI:
10.1111/j.1530-0277.2001.tb02157.x - 发表时间:
2001 - 期刊:
- 影响因子:0
- 作者:
Vania M. M. Ferreira;S. Frausto;Michael D. Browning;Daniel D. Savage;Gina S. Morato;C. Fernando Valenzuela - 通讯作者:
C. Fernando Valenzuela
Left ventricular geometry and cardiac risk factors define high and low risk subgroups among essential hypertensives
- DOI:
10.1016/0735-1097(90)92159-y - 发表时间:
1990-02-01 - 期刊:
- 影响因子:
- 作者:
Michael J. Koran;Paul N. Casale;Daniel D. Savage;John H. Laragh;Richard B. Devereux - 通讯作者:
Richard B. Devereux
Echocardiographic left ventricular mass and physical activity: quantification of the relation in spinal cord injured and apparently healthy active men.
超声心动图左心室质量和体力活动:脊髓损伤和表面健康活跃男性之间关系的量化。
- DOI:
10.1016/0002-9149(86)90391-7 - 发表时间:
1986 - 期刊:
- 影响因子:0
- 作者:
Richard A. Washburn;Daniel D. Savage;S. Dearwater;Ronald E. LaPorte;S. Anderson;Gilbert Brenes;Lucile L. Adams;Hyun Kyung M. Lee;John C. Holland;Michael L. Cowan;Edward Parks - 通讯作者:
Edward Parks
The effects of moderate prenatal alcohol exposure on performance in object and spatial discrimination tasks by adult male rats
- DOI:
10.1016/j.bbr.2024.115324 - 发表时间:
2025-02-26 - 期刊:
- 影响因子:
- 作者:
Lilliana M. Sanchez;Gabriela Acosta;Sarah D. Cushing;Sarah A. Johnson;Sean M. Turner;Suzy Davies;Daniel D. Savage;Sara N. Burke;Benjamin J. Clark - 通讯作者:
Benjamin J. Clark
Daniel D. Savage的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Daniel D. Savage', 18)}}的其他基金
Impact of SAR152954 on Prenatal Alcohol Exposure-induced Neurobehavioral Deficits
SAR152954 对产前酒精暴露引起的神经行为缺陷的影响
- 批准号:
9386533 - 财政年份:2017
- 资助金额:
$ 6.2万 - 项目类别:
Fetal ethanol-induced behavioral deficits: Mechanisms, diagnoses and intervention
胎儿乙醇引起的行为缺陷:机制、诊断和干预
- 批准号:
10207329 - 财政年份:2014
- 资助金额:
$ 6.2万 - 项目类别:
Fetal ethanol-induced behavioral deficits: Mechanisms, diagnoses and intervention
胎儿乙醇引起的行为缺陷:机制、诊断和干预
- 批准号:
9980232 - 财政年份:2014
- 资助金额:
$ 6.2万 - 项目类别:
Impact of histamine H3 receptor agents on PAE-induced synaptic plasticity deficits in dentate gyrus
组胺 H3 受体药物对 PAE 诱导的齿状回突触可塑性缺陷的影响
- 批准号:
10207335 - 财政年份:2014
- 资助金额:
$ 6.2万 - 项目类别:
Impact of histamine H3 receptor agents on PAE-induced synaptic plasticity deficits in dentate gyrus
组胺 H3 受体药物对 PAE 诱导的齿状回突触可塑性缺陷的影响
- 批准号:
10442640 - 财政年份:2014
- 资助金额:
$ 6.2万 - 项目类别:
Component 1 Admin Core Savage - Valenzuela
组件 1 管理核心 Savage - Valenzuela
- 批准号:
10674486 - 财政年份:2014
- 资助金额:
$ 6.2万 - 项目类别:
Fetal ethanol-induced behavioral deficits: Mechanisms, diagnoses and intervention
胎儿乙醇引起的行为缺陷:机制、诊断和干预
- 批准号:
10674485 - 财政年份:2014
- 资助金额:
$ 6.2万 - 项目类别:
Component 1 Admin Core Savage - Valenzuela
组件 1 管理核心 Savage - Valenzuela
- 批准号:
10442636 - 财政年份:2014
- 资助金额:
$ 6.2万 - 项目类别:
Fetal ethanol-induced behavioral deficits: Mechanisms, diagnosis and Intervention
胎儿乙醇引起的行为缺陷:机制、诊断和干预
- 批准号:
9497741 - 财政年份:2014
- 资助金额:
$ 6.2万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 6.2万 - 项目类别:
Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 6.2万 - 项目类别:
Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 6.2万 - 项目类别:
Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 6.2万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 6.2万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 6.2万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 6.2万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 6.2万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 6.2万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 6.2万 - 项目类别:
Research Grant