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Pre-and Postgraduate Training in Molecular Hematology

分子血液学预科和研究生培训

基本信息

批准号：
10676759
负责人：
Stephen Tracy Oh
金额：
$ 30.21万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1975
资助国家：
美国
起止时间：
1975-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10676759
关键词：
Training molecular hematology

项目摘要

Although advances in hematology have led the way in many fields of basic and translational biomedical research, hematologic diseases remain major threats to public health. For example, the prognosis for many hematologic malignancies continues to be poor. Current treatments are inadequate to support a normal lifestyle for most patients with sickle cell disease. In the U.S., at least 500,000 venous thromboembolic events, 1 million heart attacks and 150,000 stroke deaths occur each year. At the same time, opportunities for hematology research have never been more promising, and converting these opportunities into medical advances will depend upon training the next generation of basic and translational hematology researchers. The Molecular Hematology train- ing program proposes to fill this need for 5 predoctoral and 8 postdoctoral trainees per year. Predoctoral Ph.D. and M.D./Ph.D. students follow the curriculum of the Washington University graduate school. After passing their qualifying examination, they enter the laboratory of participating faculty Mentors for 3-4 years of laboratory re-search to complete their dissertation. Postdoctoral Ph.D. trainees from around the world apply to participating laboratories; postdoctoral M.D. and M.D./Ph.D. trainees usually have completed the clinical training component of a Hematology-Oncology fellowship program at Washington University or elsewhere. The duration of postdoc-toral training depends on prior experience. Those with Ph.D. or M.D./Ph.D degrees typically conduct research for 2-3 years before transitioning to an independent research position, whereas those with an M.D. degree may benefit from 3-4 years of postdoctoral training. Trainees receive intensive mentoring and career counseling, and participate in coursework, journal clubs, and seminars. The major facilities of the program consist of ~80,000 square feet of fully-equipped laboratory space that house the Divisions of Hematology and Oncology, as well as extensive institutional resources for genome sequencing, immune monitoring, informatics, animal studies, and patient-oriented clinical research. The research topics available to trainees reflect the multidisciplinary expertise of the participating Mentors and include: pathogenesis of hemorrhagic and thrombotic disorders; regulation of blood coagulation and fibrinolysis; gene therapy of hemophilia and lysosomal storage diseases; phosphoinosi-tide metabolism and cell signaling pathways; mechanisms of hematopoiesis; telomerase defects in bone marrow failure syndromes; molecular basis for protein trafficking in mammalian cells; role of platelets and angiogenesis in metastasis; biology of human immunodeficiency and leukemia viruses; epithelial morphogenesis; pathogene-sis of leukemia, myelodysplastic syndrome, myeloproliferative neoplasms, and congenital neutropenia; cell cycle control; programmed cell death in development and malignancy. Completion of this program will prepare talented trainees for careers in basic and translational hematology research, to make discoveries that will transform the diagnosis and treatment of hematologic diseases.

尽管血液学的进步在许多基础和转化性生物医学研究领域处于领先地位，血液病仍然是公共健康的主要威胁。例如，许多血液病的预后恶性肿瘤的发病率仍然很低。目前的治疗不足以支持大多数人的正常生活方式患有镰状细胞病的患者。在美国，至少有50万例静脉血栓形成事件，100万例心脏每年有15万人死于中风。与此同时，血液学研究的机会从来没有像现在这样有希望，而将这些机会转化为医学进步将取决于培养下一代基础和转化型血液学研究人员。分子血液学系列- ING计划计划每年培养5名博士后和8名博士后。博士前博士和医学博士/博士学生遵循华盛顿大学研究生院的课程。之后通过资格考试，他们进入参与的教师导师实验室，为期3-4年实验室研究，以完成他们的论文。来自世界各地的博士后实习生申请参与实验室；博士后医学博士和医学博士/博士实习生通常已完成临床华盛顿大学或其他地方血液学-肿瘤学奖学金计划的培训部分。这个博士后培训的持续时间取决于以前的经验。拥有博士或医学博士/博士学位的人通常进行2-3年的研究，然后过渡到独立的研究职位，而那些拥有医学博士学位的人可能会受益于3-4年的博士后培训。学员接受密集培训指导和职业咨询，并参加课程作业、杂志俱乐部和研讨会。少校该计划的设施包括大约80,000平方英尺的设备齐全的实验室空间，这些空间容纳了血液科和肿瘤科，以及广泛的基因组测序机构资源，免疫监测、信息学、动物研究和以病人为中心的临床研究。研究课题提供给学员的课程反映了参与导师的多学科专业知识，包括：出血性和血栓性疾病的发病机制；凝血和纤溶的调节；基因血友病和溶酶体储存性疾病的治疗；磷脂酰肌醇代谢和细胞信号转导途径；造血机制；骨髓衰竭综合征中的端粒酶缺陷；分子哺乳动物细胞中蛋白质运输的基础；血小板和血管生成在转移中的作用；生物学人类免疫缺陷与白血病病毒；上皮形态发生；白血病发病机制骨髓增生异常综合征、骨髓增生性肿瘤和先天性中性粒细胞减少症；细胞周期调控；发育和恶性过程中的程序性细胞死亡。完成这一计划将培养有才华的人基础血液学和转化性血液学研究的实习生，以做出将改变血液病的诊断和治疗。