Vermont Immunology / Infectious Diseases Training Grant

佛蒙特州免疫学/传染病培训补助金

• 批准号: 10686812
• 负责人: GARY E WARD
• 金额: $ 18.03万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686812
• 关键词: Communicable Diseases; Grant; Immunology; Training; Vermont

Abstract/Summary In this application, we propose to build upon the highly successful multidisciplinary training program in microbiology, immunology and infectious disease we have developed at the University of Vermont over the past 14 years. The goal of the Vermont Immunobiology and Infectious Disease (VI2D) training program, which supports four predoctoral students per year, is to produce outstanding independent biomedical scientists who are equipped to study infectious disease mechanisms, prevention, and treatment. To date, we have had 19 trainees, 13 of whom have completed their PhDs in an average of 5.3 years; the other six are still in training. Our trainees have published an average of 5.7 papers from their doctoral research (2.6 as first author) and have been included on nine patents. Eleven of the 19 trainees have been women (58%), and five (26%) have been from groups underrepresented in the scientific workforce. Importantly, all 13 of our graduates continue to pursue careers in science or medicine. The average duration of T32 support has been 2.4 years, with a maximum of 3, and the trainees have been distributed broadly among our 16 Faculty Mentors. The mentors include a mix of basic, translational, and clinical researchers, with 12 Ph.D., one Ph.D./D.V.M., and three M.D. faculty members. These training faculty are well funded (total current annual extramural support of $10.6 million), highly collaborative, and have a strong, demonstrated commitment to mentoring and graduate education. At the core of the intellectual environment supporting the program are this engaged group of Faculty Mentors, the graduate program in Cellular, Molecular and Biomedical Sciences (CMB), and two vibrant Centers of Biomedical Research Excellence funded by NIH COBRE grants: the Vermont Center for Immunobiology and Infectious Disease and the Translational Global Infectious Diseases Research Center. Institutional support for the training program is exceptional. Training grant-eligible applicants are drawn from the rich pool of students in the CMB Program and undergo a rigorous selection process before being appointed to the training grant. The VI2D program has been designed to give our trainees a deep understanding of the basic science underpinnings of immunology and microbial pathogenesis. In addition, and new to the program going forward, our trainees will a) gain real-world exposure to clinical aspects of infectious and immunological disease, through our “Clinical Connection” program that fosters interaction between the trainees and clinicians, and b) become better prepared to function as effective research scientists through training in key aspects of the “Practice of Science,” including effective communication skills, team building, career development, and personal wellness. A detailed plan for regular internal and external evaluation of the program will enable us to continuously evolve and improve the training experience. The integrated, well-resourced, multidisciplinary training plan proposed in this application will provide our trainees with a rich set of skills, tools, and experiences that will serve as excellent preparation for a successful career in infectious disease research.

摘要/摘要 在这项申请中，我们建议在非常成功的多学科培训计划的基础上 我们在佛蒙特州大学研究的微生物学、免疫学和传染病 过去的14年里。佛蒙特州免疫生物学和传染病(VI2D)培训计划的目标是 每年资助四名博士后，是为了培养优秀的独立生物医学科学家 有能力研究传染病的机制、预防和治疗。到目前为止，我们已经有19个 受训人员，其中13人平均在5.3年内完成博士学位；其他6人仍在接受培训。 我们的实习生平均发表了5.7篇博士研究论文(第一作者为2.6篇)和 已被列入九项专利。19名学员中有11名(58%)为女性，5名(26%)为女性 来自科学工作者中代表性不足的群体。重要的是，我们所有的13名毕业生继续 追求科学或医学方面的职业。T32支持的平均持续时间为2.4年， 最多3名，受训人员已广泛分布在我们的16名教师导师中。导师们 包括基础、翻译和临床研究人员，其中包括12名博士、1名博士/医学博士和3名医学博士。 教职员工。这些培训教员资金充足(目前每年的外部支助总额为10.6美元 百万美元)，高度协作，并对指导和毕业有强烈的承诺 教育。支持该计划的智力环境的核心是这群敬业的教职员工 Mentors，细胞、分子和生物医学(CMB)研究生课程，以及两个充满活力的 由NIH Cobre赠款资助的生物医学研究卓越中心：佛蒙特州中心 免疫生物学和传染病与翻译型全球传染病研究中心。 对培训计划的机构支持是例外的。符合培训补助金资格的申请者从 招商银行项目的丰富人才库，并在被任命之前经历了严格的遴选程序 给了培训补助金。VI2D计划旨在让我们的实习生深入了解 免疫学和微生物发病机制的基础科学基础。此外，这也是该计划的新功能 展望未来，我们的实习生将a)接触传染病和免疫学的临床方面。 疾病，通过我们的“临床连接”计划，促进学员和临床医生之间的互动， 和b)通过以下关键方面的培训，更好地做好作为有效研究科学家的准备 “科学实践”，包括有效的沟通技巧、团队建设、职业发展，以及 个人健康。对该计划进行定期内部和外部评估的详细计划将使我们能够 不断改进和改进培训体验。整合、资源丰富、多学科 本申请中提出的培训计划将为我们的学员提供丰富的技能、工具和 这些经验将为传染病研究的成功生涯做好极好的准备。

项目成果

Illegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing.

Notch1 和 Bcl11b 中非法 V(D)J 重组介导的缺失不足以进行广泛的克隆扩增，并且在频率或连接处理中显示出最小的年龄或性别偏差。

• DOI: 10.1016/j.mrfmmm.2014.01.007
• 发表时间: 2014
• 期刊: Mutation research
• 作者: Champagne,DevinP;Shockett,PennyE
• 通讯作者: Shockett,PennyE

SARS-CoV-2 triggers DNA damage response in Vero E6 cells.

• DOI: 10.1016/j.bbrc.2021.09.024
• 发表时间: 2021-11-19
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Victor J;Deutsch J;Whitaker A;Lamkin EN;March A;Zhou P;Botten JW;Chatterjee N
• 通讯作者: Chatterjee N

Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus.

• DOI: 10.1016/j.immuni.2016.02.018
• 发表时间: 2016-06-21
• 期刊: Immunity
• 影响因子: 32.4
• 作者: Champagne DP;Hatle KM;Fortner KA;D'Alessandro A;Thornton TM;Yang R;Torralba D;Tomás-Cortázar J;Jun YW;Ahn KH;Hansen KC;Haynes L;Anguita J;Rincon M
• 通讯作者: Rincon M

Creatine utilization as a sole nitrogen source in Pseudomonas putida KT2440 is transcriptionally regulated by CahR.

恶臭假单胞菌 KT2440 中肌酸作为唯一氮源的利用受到 CahR 的转录调控。

• DOI: 10.1099/mic.0.001145
• 发表时间: 2022
• 期刊: Microbiology (Reading, England)
• 作者: Hinkel,LaurenA;Willsey,GrahamG;Lenahan,SeanM;Eckstrom,Korin;Schutz,KristinC;Wargo,MatthewJ
• 通讯作者: Wargo,MatthewJ

Organoid-based in vitro systems to model Cryptosporidium parvum infection in 2D and 3D.

基于类器官的体外系统，用于模拟 2D 和 3D 隐孢子虫感染。

• DOI: 10.1101/2023.09.29.560165
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Korwin-Mihavics,BethanyR;Dews,EmmettA;diGenova,BrunoMartorelli;Huston,ChristopherD
• 通讯作者: Huston,ChristopherD