Targeted Circuit Manipulation for Ameliorating Huntington's Disease Pathogenesis

改善亨廷顿病发病机制的靶向电路操作

基本信息

  • 批准号:
    10841909
  • 负责人:
  • 金额:
    $ 1.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-07-01 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT The Diversity Supplement candidate will be trained in all aspects of manipulating the firing activity within the cortico-striatal microcircuit by chemogenetic inhibition of pyramidal neurons, testing efficacy of inhibition by electrophysiological recordings in vivo, and assessing in behavioral tests if these manipulations before the onset of symptoms will slow HD disease progression. The training includes stereotaxic injections of AAV, acute extracellular recordings and computational electrophysiological data analysis, and conducting behavioral test batteries and analyzing the collected data. The experimental approach will allow the candidate to assess the efficacy of novel inhibitory luminopsins within this well-defined experimental paradigm while building a solid conceptual and experimental foundation for his future activities in biomedical research. The training experiences the candidate will gain are critical for his understanding and interpretation of state-of- the-art neuroscience experiments. The training plan takes into consideration that the candidate is at the very beginning of his research training and ensures that the candidate will have an exceedingly strong background for entering the next phase of research training towards meeting his career goals. His training will have ranged from hands-on experience in executing in vivo experiments for controlling neural activity and behavior to evaluating and interpreting the collected data. Therefore, this training in in vivo electrophysiology and behavior testing will not only significantly contribute to the parent grant but will specifically provide him the experience required to pursue his long-term interest in pursuing a career as a physician-scientist. The proposed training outlined in the application is ideal given the candidate’s career stage and future plans and is tailored to having the greatest impact within th ehsortest possible time. An established training strategy will foster the candidate’s ability to swiftly reach a level where he can independently approach new projects and will be an asset to any research lab where he continues his training. The proposed supplement activities will increase the parent award’s overall impact within the original scope of award while at the same time advancing the training and career development of the candidate.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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UTE H HOCHGESCHWENDER其他文献

UTE H HOCHGESCHWENDER的其他文献

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{{ truncateString('UTE H HOCHGESCHWENDER', 18)}}的其他基金

Selective Control of Synaptically-Connected Circuit Elements by Interluminescence - Diversity Supplement SILVAGNOLI
通过间发光选择性控制突触连接的电路元件 - Diversity Supplement SILVAGNOLI
  • 批准号:
    10731169
  • 财政年份:
    2023
  • 资助金额:
    $ 1.5万
  • 项目类别:
Targeted Circuit Manipulation for Ameliorating Huntington's Disease Pathogenesis
改善亨廷顿病发病机制的靶向电路操作
  • 批准号:
    10646867
  • 财政年份:
    2023
  • 资助金额:
    $ 1.5万
  • 项目类别:
Selective Control of Synaptically-Connected Circuit Elements by Interluminescence
通过间发光选择性控制突触连接的电路元件
  • 批准号:
    10165226
  • 财政年份:
    2021
  • 资助金额:
    $ 1.5万
  • 项目类别:
Selective Control of Synaptically-Connected Circuit Elements by Interluminescence - Diversity Supplement: E. CRESPO
通过间发光选择性控制突触连接的电路元件 - 多样性补充:E. CRESPO
  • 批准号:
    10406018
  • 财政年份:
    2021
  • 资助金额:
    $ 1.5万
  • 项目类别:
BioLuminescent OptoGenetics (BL-OG): A Novel and Versatile Strategy for Neuromodulation
生物发光光遗传学 (BL-OG):一种新颖且多功能的神经调节策略
  • 批准号:
    9356587
  • 财政年份:
    2016
  • 资助金额:
    $ 1.5万
  • 项目类别:
BioLuminescent OptoGenetics (BL-OG): A Novel and Versatile Strategy for Neuromodulation
生物发光光遗传学 (BL-OG):一种新颖且多功能的神经调节策略
  • 批准号:
    9492447
  • 财政年份:
    2016
  • 资助金额:
    $ 1.5万
  • 项目类别:
BioLuminescent OptoGenetics (BL-OG): A Novel and Versatile Strategy for Neuromodulation
生物发光光遗传学 (BL-OG):一种新颖且多功能的神经调节策略
  • 批准号:
    9231901
  • 财政年份:
    2016
  • 资助金额:
    $ 1.5万
  • 项目类别:
BioLuminescent OptoGenetics (BL-OG): A Novel and Versatile Strategy for Neuromodulation
生物发光光遗传学 (BL-OG):一种新颖且多功能的神经调节策略
  • 批准号:
    9492464
  • 财政年份:
    2016
  • 资助金额:
    $ 1.5万
  • 项目类别:
Employing subcellular calcium to control membrane voltage
利用亚细胞钙来控制膜电压
  • 批准号:
    9136155
  • 财政年份:
    2015
  • 资助金额:
    $ 1.5万
  • 项目类别:
Genetically Encoded Light-Production and Light-Sensing for Neuronal Manipulation
用于神经元操纵的基因编码光产生和光传感
  • 批准号:
    8971048
  • 财政年份:
    2014
  • 资助金额:
    $ 1.5万
  • 项目类别:

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