Integrated Neural Engineering and Rehabilitation Training Program

综合神经工程与康复训练计划

• 批准号: 10838108
• 负责人: Jeffrey R Capadona
• 金额: $ 10.76万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10838108
• 关键词: Engineering; Rehabilitation therapy; Training Programs; neural

This proposal describes our “Integrated Neural Engineering and Rehabilitation Training” program that produces biomedical engineering Ph.D. graduates who combine state-of-the-art expertise in neural engineering (an area of bioengineering) with a genuine appreciation of the practice and challenges of clinical rehabilitation. This T32 is centered in the Department of Biomedical Engineering at Case Western Reserve University, but also includes the strong participation of several of our local medical centers. Our T32 is focused exclusively on predoctoral training - having trained 76 students since 1999. We are requesting funding for 2 supplemental predoctoral positions for one year, with institutional funds to support their second year in the training program. We expect to train a total 8 BME Ph.D. students per year with this added supplement to our program. Trainees enter with undergraduate training in engineering or a closely related discipline. They satisfy the rigorous requirements of the BME Ph.D. program and benefit from its existing features, while our T32 program adds value through highly collaborative and interdisciplinary research projects, a clinical immersion experience, and unique access to visiting seminar speakers. We are creating a virtual reality-based Neural Anatomy course (exploiting our unique relationship with the Microsoft HoloLens program), including formal and informal diversity training, and diversifying out mentoring pool with more faculty with industry experience, underrepresented trainers, to facilitate the recruitment and training of women, minorities, and disadvantaged students to the program. The specific objectives of our training program are: (1) Prepare our trainees for productive careers in rehabilitation and neural engineering; (2) Provide a rigorous engineering education that forms the basis for future innovation; (3) Provide specific expertise in the development and application of neural stimulation and interventions for overcoming neurological disorders; (4) Provide specific expertise in modeling and simulation; (5) Provide an extensive, hands-on clinical immersion experience that prepares each trainee for a translational career; (6) Provide specific expertise in the deployment and integration of Brain Computer Interfaces; and (7) Provide real-world professional development training to enhance post-graduation success. We have assembled a distinguished group of mentors who serve in one of three roles: Research Training mentors (17) who are the primary research advisors of the trainees, Associate Research Training Mentors (5) who are content experts on T32 trainee committees, and Clinical Training Mentors (12) from rehabilitation and surgical disciplines who insure the clinical relevance of each trainee research project. We are in the process of adding new mentors (3) to further diversity the mentor pool. Trainee project topics include electrode development; brain computer interfacing; sensory restoration; pain management; stimulation pattern design; neural motor control mechanisms; neural biomaterials, protection, and repair; interventions to individuals with neurological disorders; neurorehabilitation; modeling and simulation; and brain-computer interfacing.

该提案描述了我们的“综合神经工程和康复训练”计划， 培养出生物医学工程博士联合收割机结合了神经工程领域最先进的专业知识 (an生物工程领域），真正了解临床康复的实践和挑战。 这台T32位于凯斯西储大学生物医学工程系，但也 包括我们当地几个医疗中心的大力参与。我们的T32专注于 博士前培训-自1999年以来已培训了76名学生。我们正在申请2项补充资金 博士前职位一年，与机构资金，以支持他们在培训计划的第二年。 我们预计将培养8个BME博士。学生每年与此增加补充我们的计划。学员 进入工程或密切相关的学科的本科培训。他们满足了严格的 BME博士的要求计划并从其现有功能中受益，而我们的T32计划则增加了价值 通过高度协作和跨学科的研究项目，临床沉浸式体验，以及独特的 访问研讨会发言人。我们正在创建一个基于虚拟现实的神经解剖学课程（利用 我们与微软HoloLens计划的独特关系），包括正式和非正式的多元化培训， 并通过更多具有行业经验的教师，代表性不足的培训师， 为该方案招募和培训妇女、少数民族和弱势学生提供便利。 我们的培训计划的具体目标是：（1）为我们的学员在以下方面的生产性职业做好准备： 康复和神经工程;（2）提供严格的工程教育，形成未来的基础 创新;（3）在神经刺激的开发和应用方面提供特定的专业知识， （4）提供建模和仿真方面的专门知识; (5)提供广泛的，动手的临床沉浸式经验，为每个受训者做好翻译准备 职业生涯;（6）提供脑机接口部署和集成方面的特定专业知识;以及（7） 提供真实世界的专业发展培训，以提高毕业后的成功。 我们召集了一批杰出的导师，他们担任以下三个角色之一： 导师（17）谁是学员的主要研究顾问，副研究培训导师（5） 他们是T32学员委员会的内容专家，以及来自康复和 确保每个实习研究项目的临床相关性的外科学科。我们正在 增加新的指导者（3）以进一步使指导者库多样化。实习生项目主题包括电极 开发;脑机接口;感觉恢复;疼痛管理;刺激模式设计; 神经运动控制机制;神经生物材料，保护和修复;对患有 神经障碍;神经康复;建模和仿真;以及脑机接口。

项目成果

Measuring embodiment: A review of methods for prosthetic devices.

• DOI: 10.3389/fnbot.2022.902162
• 发表时间: 2022
• 期刊: FRONTIERS IN NEUROROBOTICS
• 影响因子: 3.1
• 作者: Segil, Jacob L.;Roldan, Leah Marie;Graczyk, Emily L.
• 通讯作者: Graczyk, Emily L.

Standing after spinal cord injury with four-contact nerve-cuff electrodes for quadriceps stimulation.

• DOI: 10.1109/tnsre.2008.2003390
• 发表时间: 2008-10
• 期刊: IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
• 作者: Fisher LE;Miller ME;Bailey SN;Davis JA Jr;Anderson JS;Rhode L;Tyler DJ;Triolo RJ
• 通讯作者: Triolo RJ

Case study: Head orientation and neck electromyography for cursor control in persons with high cervical tetraplegia.

案例研究：头部方向和颈部肌电图用于高位颈椎四肢瘫痪患者的光标控制。

• DOI: 10.1682/jrrd.2014.10.0244
• 发表时间: 2016
• 期刊: Journal of rehabilitation research and development
• 作者: Williams,MatthewR;Kirsch,RobertF
• 通讯作者: Kirsch,RobertF

Reconnecting the Hand and Arm to the Brain: Efficacy of Neural Interfaces for Sensorimotor Restoration after Tetraplegia.

将手和手臂重新连接到大脑：神经接口对四肢瘫痪后感觉运动恢复的功效。

• DOI: 10.1101/2023.04.24.23288977
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Herring,EricZ;Graczyk,EmilyL;Memberg,WilliamD;Adams,RobertD;Baca-Vaca,GuadalupeFernandez;Hutchison,BriannaC;Krall,JohnT;Alexander,BenjaminJ;Conlan,EmilyC;Alfaro,KenyaE;Bhat,PreethiR;Ketting-Olivier,AaronB;Haddix,Chase
• 通讯作者: Haddix,Chase

Evaluation of head orientation and neck muscle EMG signals as three-dimensional command sources.

评估头部方向和颈部肌肉肌电图信号作为三维命令源。

• DOI: 10.1186/s12984-015-0016-6
• 发表时间: 2015
• 期刊: Journal of neuroengineering and rehabilitation
• 影响因子: 5.1
• 作者: Williams,MatthewR;Kirsch,RobertF
• 通讯作者: Kirsch,RobertF