Southern California Center for Chronic Health Disparities in Latino Children and Families.

南加州拉丁裔儿童和家庭慢性健康差异中心。

• 批准号: 10892510
• 负责人: Michael Isaac Goran
• 金额: $ 81.98万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10892510
• 关键词: Acceleration; Accounting; Address; Adult; Affect; Artificial Intelligence; Attitude; Behavior; Beverages; Blood Glucose; California; Cellular Phone; Centers for Disease Control and Prevention (U.S.); Child; Chronic; Chronic Disease; Clip; Cohort Studies; Collaborations; Communities; Community Health Aides; Computers; Continuous Glucose Monitor; Coupled; Data; Development; Devices; Diabetes Mellitus; Diabetes prevention; Diet Records; Disparity; Eating; Education; Emerging Technologies; Ethnic Origin; Face; Family; Feasibility Studies; Feedback; Food; Goals; Health; Hospitalization; Household; Individual; Intake; Intervention; Interview; Knowledge; Language; Latino; Latino Population; Learning; Link; Longitudinal cohort study; Masks; Measures; Methods; Monitor; Morbidity - disease rate; Mothers; Multimedia; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Outcome; Outcome Measure; Overweight; Parents; Participant; Persons; Phase; Physicians; Population; Prediabetes syndrome; Prevalence; Prevention education; Public Health; Race; Request for Applications; Research; Sampling; Series; Structure; Study of Latinos; Technology; Testing; Text; Time; Translations; United States; Video Recording; Visual; Work; behavior change; dietary; effectiveness evaluation; experience; feasibility testing; glycemic control; health disparity; improved; information gathering; innovation; intervention program; monitoring device; mortality; novel therapeutic intervention; prevent; programs; recruit; satisfaction; sensor; success; therapy development; tool

Project Summary/Abstract The prevalence of prediabetes and type 2 diabetes (T2D) among Latino adults in the United States is a significant health concern. With T2D affecting approximately 15% of Latinos, accounting for about 10 million individuals, there is a clear disparity compared to non-Hispanic Whites. The overarching goal of this innovative intervention project is to enhance glycemic control in individuals with prediabetes and prevent the progression to T2D among Latinos. This project aims to develop and evaluate a new intervention, called Mi Control!, which combines continuous glucose monitoring (CGM) feedback using the latest non-invasive self-monitoring technology with T2D prevention educational video clips. The intervention will specifically target the needs of Latinos, based on information gathered from the experiences and feedback of Spanish- and/or English- speaking Latino community health workers (Promotores) wearing CGM devices. The project consists of three iterative studies to achieve its objectives: Study 1: This intervention development study will involve 20 Promotores de salud, who will wear a CGM sensor for 14 days. The sensor will provide real-time smartphone visual and audio feedback on glycemic variability, and participants will maintain timestamped dietary records. Video-recorded interviews will be conducted to capture the experiential narrative and explore the benefits, barriers, and behavior changes related to the CGM device. Video clips will be selected and edited from these interviews to create a series of smartphone-based educational clips for the intervention. An artificial intelligence (AI) tool will be utilized for language translation. Study 2: This feasibility study aims to assess the impact of Mi Control! on glycemic data capture and outcomes among an independent sample of 30 Promotores with prediabetes. Participants will wear the CGM device for 14 days, and the study will include a control period followed by a period with unmasked CGM glycemic feedback and smartphone text links to the Mi Control! video clips. Measures of satisfaction with the CGM device and the intervention will be collected. The study will evaluate the feasibility of Mi Control! augmented by the AI tool for language translation, and its impact on glycemic control and knowledge retention among the Latino Promotores with confirmed prediabetes. Study 3: This generality study aims to assess the effectiveness of Mi Control! on glycemic control and dietary behavior among a community-based sample of 40 Latino parents with confirmed prediabetes. Participants will be parents of children recruited from an ongoing cohort study of Latino families (Center Project 1). Participants will experience the same study method as in Study 2 and glycemic control and dietary behavior during the masked and unmasked phases will be compared. Overall, this project will contribute to the development of an innovative intervention to improve prediabetes glycemic control and prevent T2D in the Latino population. By utilizing emerging technologies, such as CGM and AI, and tailoring the intervention to the specific needs of Latinos, this research aims to address the significant health disparities observed in this population.

项目总结/摘要 美国拉丁美洲成年人中糖尿病前期和2型糖尿病（T2 D）的患病率是一个 严重的健康问题。T2 D影响了大约15%的拉丁美洲人，约占1000万 与非西班牙裔白人相比，有明显的差异。这一创新的总体目标 干预项目是加强糖尿病前期个体的血糖控制， 到T2 D之间的关系该项目旨在开发和评估一种新的干预措施，称为Mi Control！这 将动态血糖监测（CGM）反馈与最新的无创自我监测相结合 技术与T2 D预防教育视频剪辑。干预措施将具体针对以下方面的需要： 拉丁美洲人，根据从西班牙语和/或英语的经验和反馈收集的信息- 说拉丁裔社区卫生工作者（Promotores）佩戴CGM设备。该项目包括三个 迭代研究，以实现其目标：研究1：这项干预发展研究将涉及20 Promotores de salud将佩戴CGM传感器14天。该传感器将提供实时智能手机 关于血糖变化的视觉和听觉反馈，参与者将保持带时间戳的饮食记录。 将进行录像采访，以捕捉经验叙述和探索的好处， 与CGM器械相关的障碍和行为变化。视频剪辑将从这些选择和编辑 访谈，以创建一系列基于智能手机的教育剪辑的干预。一个人工智能 (AI)工具将用于语言翻译。研究2：本可行性研究旨在评估Mi的影响 控制！在30名Promotores的独立样本中， 糖尿病前期参与者将佩戴CGM设备14天，研究将包括一个对照期 随后是一段时间的非掩蔽CGM血糖反馈和智能手机文本链接到Mi Control！ 视频剪辑。将收集CGM器械和干预的满意度指标。这项研究将 评估Mi Control的可行性！人工智能语言翻译工具的增强，以及其对 确诊为糖尿病前期的拉丁裔促销员的血糖控制和知识保留。研究3： 本一般性研究旨在评估Mi Control的有效性！血糖控制和饮食行为 在一个以社区为基础的样本中，有40名拉丁裔父母被证实患有糖尿病前期。参与者将被 从正在进行的拉丁裔家庭队列研究（中心项目1）招募的儿童的父母。参与者将 经历与研究2中相同的研究方法以及在设盲期间的血糖控制和饮食行为 并且将比较未掩蔽的相位。总的来说，该项目将有助于发展一个 创新的干预措施，以改善糖尿病前期血糖控制和预防2型糖尿病在拉丁美洲人口。通过 利用CGM和AI等新兴技术，并根据患者的具体需求定制干预措施， 拉丁美洲人，这项研究旨在解决在这一人群中观察到的显著健康差距。

项目成果

County-Level Social Vulnerability Is Positively Associated with Cardiometabolic Disease in Colorado.

• DOI: 10.3390/ijerph19042202
• 发表时间: 2022-02-15
• 期刊: International journal of environmental research and public health
• 作者: Wild LE;Walters M;Powell A;James KA;Corlin L;Alderete TL
• 通讯作者: Alderete TL

Effects of Dietary Sugar Reduction on Biomarkers of Cardiometabolic Health in Latino Youth: Secondary Analyses from a Randomized Controlled Trial.

• DOI: 10.3390/nu15153338
• 发表时间: 2023-07-27
• 期刊: NUTRIENTS
• 影响因子: 5.9
• 作者: Schmidt, Kelsey A.;Mokhtari, Pari;Holzhausen, Elizabeth A.;Alderete, Tanya L.;Allayee, Hooman;Nayak, Krishna S.;Sinatra, Frank R.;Pickering, Trevor A.;Mack, Wendy;Kohli, Rohit;Goran, Michael I.
• 通讯作者: Goran, Michael I.

Characterizing alterations in the gut microbiota following postpartum weight change.

• DOI: 10.1128/msystems.00808-23
• 发表时间: 2023-12-21
• 期刊: mSystems
• 影响因子: 6.4

Food prescription pilots: feasibility, acceptability and affordability of improving diet through menu planning and grocery delivery.

食品处方试点：通过菜单规划和杂货配送改善饮食的可行性、可接受性和负担能力。

• DOI: 10.1111/jhn.13142
• 发表时间: 2023
• 期刊: Journal of human nutrition and dietetics : the official journal of the British Dietetic Association
• 作者: Cohen,DeborahA;Estrada,ErikaL;Montes,Monica;Voorhees,AllisonC;Inzhakova,Galina;Rios,Claudia;Hsieh,Timothy;Tayag,Justin;Castillo,Amorette;Hashmi,Sean
• 通讯作者: Hashmi,Sean

An Affordable and Sustainable Thrifty-Like Meal Plan, FoodRx, That Meets the Recommended Dietary Allowances.

FoodRx 是一种经济实惠且可持续的节俭式膳食计划，符合建议的膳食摄入量。

• DOI: 10.1007/s11524-024-00843-1
• 发表时间: 2024
• 期刊: Journal of urban health : bulletin of the New York Academy of Medicine
• 作者: Cohen,DeborahA;Puttock,Eric;Montes,Monica;Lopez,Kelly;Labisi,Titi;Voorhees,Allison;Arriola,Freddy;Robinson,Brooke;Hashmi,Sean
• 通讯作者: Hashmi,Sean