Vanderbilt Mouse Metabolic Physiology Center

拟建的小鼠代谢生理学中心（MMPC）是一个跨学科项目，将扩大范德比尔特大学已经广泛的能力，以独特地表征糖尿病和相关疾病的表型或基因改变小鼠模型。此外，它将提供一种工具，使这些新的资源可供全国的调查人员使用。MMPC将是独立的，因为它将有能力对小鼠进行饲养和实验，分析来自这些小鼠的组织或血液样本，并管理中心程序产生的数据。MMPC将由五个核心组成。行政核心将提供科学、财政和行政领导，与NIH的项目官员互动，并管理试点和可行性（P&F）项目。行政核心还将支持中心数据管理资源在开发和管理中心小鼠表型数据库方面的作用，以允许调查人员和其他国家中心控制访问。动物护理和福利中心将执行日常的老鼠护理、老鼠繁殖和其他国家中心。动物护理和福利核心将负责小鼠的日常护理、小鼠繁殖、血液和组织收集以及基因分型。代谢病理生理学，血管病理学和分析资源核心实验室将执行表型程序。病理生理学和分析资源核心实验室将执行表型程序。病理生理学和分析资源核心实验室将执行表型程序。核心提供的服务将涉及独特的实验程序和针对小鼠的分析技术，这些通常不适合单个研究人员在自己的实验室中建立。范德比尔特大学是美国第一个也是最古老的联邦资助的糖尿病中心统一的糖尿病和代谢研究的领先站点。MMPC的建立将使范德比尔特大学在糖尿病和相关疾病方面的专业知识与已开发的和不断发展的资源相结合，以研究小鼠。

The proposed Mouse Metabolic Physiology Center (MMPC) is an interdisciplinary program that will expand the already extensive capacity at Vanderbilt to uniquely characterize the phenotype or genetically altered murine models of diabetes and related disorders. Moreover, it will provide a vehicle for making these novel resources available to investigators nationally. The MMPC will be self-contained in that it will have the capacity to perform husbandry and experimentation of a mouse line, analysis of tissue or blood samples from those mice, and management of data generated as a result of Center procedures. The MMPC will consist of five cores. The Administrative Core will provide scientific, financial, and administrative leadership, interact with program officials at the NIH, and administer the Pilot and Feasibility (P&F) Program. The Administrative Core will also support the role of the Center's Data Management Resource in developing and managing the Center mouse phenotyping database in a way that allows controlled access to investigators and other national centers. The Animal Care and Welfare Core will perform daily mouse care, mouse breeding, other national centers. The Animal Care and Welfare Core will perform daily mouse care, mouse breeding, collection of blood and tissues, and genotyping. The Metabolic Pathophysiology, the Vascular Pathology, and the Analytical Resources Core Laboratories will perform the phenotyping procedures. Pathophysiology, and the Analytical Resources Core Laboratories will perform the phenotyping procedures. Pathophysiology, and the Analytical Resources Core Laboratories will perform the phenotyping procedures. Services provided by cores will involve unique experimental procedures and analytical techniques scaled to the mouse that are generally not feasible for individual investigators to establish in their own laboratories. Vanderbilt is a leading site for research in diabetes and metabolism that is unified by the nation's first and consequently oldest federally funded diabetes center. Establishment of the MMPC will allow the expertise in diabetes and related disorders at Vanderbilt to be merged with developed and evolving resources to study the mouse.