UCD MUTANT MOUSE REGIONAL RESOUCE CENTER

都柏林大学突变小鼠区域资源中心

• 批准号: 6616218
• 负责人: STEPHEN WILLIAM BARTHOLD
• 金额: $ 129.06万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6616218
• 关键词: Internet; animal breeding; animal colony; biomedical resource; cryopreservation; in vitro fertilization; information systems; laboratory mouse; magnetic resonance imaging; miniature biomedical equipment; mutant; phenotype; sperm

The University of California, Davis (UCD) proposes to build upon existing expertise, technology, and facilities of its own Mouse Biology Program to establish a Mutant Mouse Regional Resource Center (MMRRC) as part of a regional center of excellence in Mouse Biology. The UCD-MMRRC will coordinate its activities with the national Coordinating Committee and establish efficient and responsive computer linkage with the Informatics Coordinating Center. UCD will offer its existing broad range of expertise to respond flexibly to the varied needs of mutant mice and their scientific constituency. This flexible approach is required for effective importation, rederivation, cryopreservation, maintenance, breeding, distribution, and revitalization from the cryopreserved state. These functions will be enhanced by a consulting arrangement with scientists at The Jackson Laboratory, and via an informal partnership with Harlan Sprague Dawley, Inc. for efficient distribution of mice created by the UCD MMRRC. UCD research programs in mouse sperm cryopreservation, with collaboration of scientists at the University of Hawaii, miniaturized magnetic resonance imaging, and an integrative comprehensive network of phenotyping expertise are offered to enhance the MMRRC and the national MMRRC network. The MMRRC will support programs in phenotyping and development of an interactive internet site, termed The Visible Mouse, which will make data on normal anatomy and pathology of mutant mice accessible to the national scientific community.

加州大学戴维斯分校 (UCD) 提议利用其小鼠生物学项目的现有专业知识、技术和设施，建立突变小鼠区域资源中心 (MMRRC)，作为小鼠生物学区域卓越中心的一部分。 UCD-MMRRC 将与国家协调委员会协调其活动，并与信息学协调中心建立高效且反应灵敏的计算机连接。 都柏林大学将提供其现有的广泛专业知识，以灵活应对突变小鼠及其科学界的不同需求。 这种灵活的方法是有效导入、再衍生、冷冻保存、维护、繁殖、分配和从冷冻状态恢复活力所必需的。 这些功能将通过与杰克逊实验室科学家的咨询安排以及与 Harlan Sprague Dawley, Inc. 的非正式合作伙伴关系得到加强，以有效分配 UCD MMRRC 所创造的小鼠。 都柏林大学与夏威夷大学科学家合作，提供小鼠精子冷冻保存研究项目、微型磁共振成像和表型专业知识的综合综合网络，以增强 MMRRC 和国家 MMRRC 网络。 MMRRC 将支持表型分析项目和一个名为“可见小鼠”的交互式网站的开发，该网站将使国家科学界能够获取突变小鼠的正常解剖学和病理学数据。