UCD MUTANT MOUSE REGIONAL RESOUCE CENTER

加州大学戴维斯分校（UCD）提议在其小鼠生物学项目现有的专业知识、技术和设施的基础上，建立一个突变小鼠区域资源中心（MMRRC），作为小鼠生物学区域卓越中心的一部分。UCD-MMRRC将与国家协调委员会协调其活动，并与信息学协调中心建立有效和反应迅速的计算机联系。UCD将提供其现有的广泛的专业知识，以灵活地应对突变小鼠及其科学选区的各种需求。这种灵活的方法需要有效的进口、再衍生、冷冻保存、维护、繁殖、分发和从冷冻状态恢复。这些功能将通过与杰克逊实验室科学家的咨询安排，以及通过与Harlan Sprague Dawley， Inc.的非正式合作伙伴关系来增强，以便有效地分配由UCD MMRRC创建的小鼠。UCD在小鼠精子冷冻保存方面的研究项目，与夏威夷大学的科学家合作，提供小型化磁共振成像和综合综合的表型专业知识网络，以增强MMRRC和国家MMRRC网络。MMRRC将支持表现型项目和一个名为“可见小鼠”的互动网站的开发，该网站将使国家科学界能够获得突变小鼠的正常解剖和病理数据。

The University of California, Davis (UCD) proposes to build upon existing expertise, technology, and facilities of its own Mouse Biology Program to establish a Mutant Mouse Regional Resource Center (MMRRC) as part of a regional center of excellence in Mouse Biology. The UCD-MMRRC will coordinate its activities with the national Coordinating Committee and establish efficient and responsive computer linkage with the Informatics Coordinating Center. UCD will offer its existing broad range of expertise to respond flexibly to the varied needs of mutant mice and their scientific constituency. This flexible approach is required for effective importation, rederivation, cryopreservation, maintenance, breeding, distribution, and revitalization from the cryopreserved state. These functions will be enhanced by a consulting arrangement with scientists at The Jackson Laboratory, and via an informal partnership with Harlan Sprague Dawley, Inc. for efficient distribution of mice created by the UCD MMRRC. UCD research programs in mouse sperm cryopreservation, with collaboration of scientists at the University of Hawaii, miniaturized magnetic resonance imaging, and an integrative comprehensive network of phenotyping expertise are offered to enhance the MMRRC and the national MMRRC network. The MMRRC will support programs in phenotyping and development of an interactive internet site, termed The Visible Mouse, which will make data on normal anatomy and pathology of mutant mice accessible to the national scientific community.