University of Iowa Institutional Training Program in Oral Health Research

爱荷华大学口腔健康研究机构培训计划

• 批准号: 10710934
• 负责人: STEVEN M. LEVY
• 金额: $ 48.04万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10710934
• 关键词: Academia; Address; Advisory Committees; Area; Behavioral Sciences; Big Data; Biocompatible Materials; Biomedical Engineering; Biometry; Clinical; Critiques; Dental; Dental caries; Dentistry; Dentists; Discipline; Doctor of Philosophy; Education; Educational process of instructing; Educational workshop; Environment; Epidemiology; Faculty; Fellowship; Funding; Genetic; Grant; Health Policy; Health Sciences; Immunology; Inflammation; Institution; Interdisciplinary Study; International; Iowa; K-Series Research Career Programs; Leadership; Mentors; Microbiology; Odontogenesis; Oral; Oral health; Outcome; Postdoctoral Fellow; Productivity; Public Health; Research; Research Personnel; Research Training; Science; Series; Tissue Engineering; Training; Training Programs; Translational Research; Universities; Update; Writing; career; clinical investigation; cohort; college; craniofacial; experience; faculty mentor; improved; leadership development; malignant mouth neoplasm; microbiome; oral biology; pre-doctoral; programs; recruit; research facility; skills; stem cells; success; translational scientist

Project Summary This competitive renewal application proposes to continue our program to provide comprehensive, integrated training in dental and craniofacial research at the University of Iowa (UI) to a cohort of basic, clinical, and translational researchers and dental scholars. It will provide dentists and non-dentists with a comprehensive skillset to meet the challenges of oral health research in academia for the 21st century. Outstanding interdisciplinary didactic training and rigorous research mentoring will emphasize ongoing review and critique. The proposed program builds on 37 years of research training success, with several major enhancements listed briefly below. The program addresses 7 major research training areas: 1) Craniofacial, Oral Biology, Genetics, and Dental Development; 2) Bioengineering, Tissue Engineering, Stem Cells, Biomaterials, and Materials; 3) Immunology, Inflammation, Microbiology, Caries, and Microbiome; 4) Oral Cancer; 5) Public Health, Epidemiology, and Behavioral Sciences; 6) Oral Health Policy; and 7) Clinical, Translational, and Big Data Research, reflecting the strengths of the College of Dentistry, UI health science colleges, and collaborative institutes and centers. Trainees in the proposed program will pursue a PhD in Oral Science (or in one of the 13 other affiliated PhD programs) or a post-doctoral fellowship. In addition, trainees now will be able to obtain a Graduate Certificate in College Teaching, Biostatistics, or Translational and Clinical Investigation or an MS in Dental Public Health. The T90 will support 4 non-dentist predocs and 2 dentists for the PhD (3 years each) and 1 non-dentist postdoc (2 years). The R90 component reflects the importance international dentists have in U.S. oral health research programs and will support 2 dentists for the PhD (3 years each). A group of 28 experienced program faculty from a variety of disciplines is available to mentor trainees. The success of our program over the past 4+ years is seen in 5 trainees receiving F- or K-awards since 2019 and trainees’ successful career placement. To build on this success, we propose several improvements/new major components of this Oral Health Research Institutional Training Program. The successful Grant-Writing Workshop Series has been updated and enhanced. Additionally, we propose several new programs, including ones in Research Rigor, Research Leadership Development, and Interdisciplinary Faculty Mentoring. Training will be supervised by the experienced Director and Associate Director and implemented in concert with a Faculty Leadership Team. Several committees will support the program: internal and external advisory committees, importantly a Committee on Recruitment and Diversity, and other component-specific committees. In summary, the program brings together productive, well-funded mentors with pre- and post-doctoral trainees in an environment with a strong institutional commitment, outstanding interdisciplinary research training in relevant disciplines, and excellent educational and research facilities. The outcome will be a cadre of oral health researchers ready to function at the cutting edge of their disciplines.

项目摘要 这种竞争性的更新申请建议继续我们的计划，以提供全面，综合 在爱荷华州（UI）的牙科和颅面研究培训的基础，临床， 翻译研究人员和牙科学者。它将为牙医和非牙医提供一个 全面的技能，以迎接挑战的口腔健康研究在学术界的世纪。 杰出的跨学科教学培训和严格的研究指导将强调持续的审查 和批评。拟议的计划建立在37年的研究培训成功的基础上，有几个主要的 下面简要列出了增强功能。该计划涉及7个主要的研究培训领域：1）颅面， 口腔生物学，遗传学和牙齿发育; 2）生物工程，组织工程，干细胞， 生物材料和材料; 3）免疫学、炎症、微生物学、龋齿和微生物组学; 4）口腔 癌症; 5）公共卫生，流行病学和行为科学; 6）口腔健康政策;和7）临床， 翻译和大数据研究，反映了牙科学院的优势，UI健康科学 学院和合作机构和中心。在拟议的计划的学员将追求博士学位在口头 科学（或在其他13个附属博士课程之一）或博士后奖学金。此外，受训人员 现在我将能够获得大学教学，生物统计学或翻译和临床研究生证书 研究或牙科公共卫生硕士学位。T90将支持4名非牙医predocs和2名牙医， 博士（各3年）和1名非牙医博士后（2年）。R90组件反映了 国际牙医在美国的口腔健康研究计划，并将支持2牙医博士（3 年）。一个由28名来自不同学科的经验丰富的项目教师组成的小组可供指导 实习生我们的计划在过去4年多的成功是在5名学员获得F-或K-奖 及学员成功就业。为了巩固这一成功，我们提出了几项建议。 本口腔健康研究机构培训计划的改进/新的主要组成部分。的 成功的赠款写作研讨会系列已更新和增强。此外，我们还提出了几个 新计划，包括研究严谨性，研究领导力发展和跨学科 教师指导。培训将由经验丰富的主任和副主任监督， 与学院领导团队合作实施。几个委员会将支持该计划： 内部和外部咨询委员会，重要的是招聘和多样性委员会，以及其他 具体委员会。总之，该计划汇集了富有成效，资金充足的导师 与前和博士后实习生在一个环境与强大的机构承诺，杰出的 相关学科的跨学科研究培训，以及一流的教育和研究设施。的 其成果将是一批口腔健康研究人员，他们随时准备在各自学科的前沿发挥作用。

项目成果

Amine modification of nonporous silica nanoparticles reduces inflammatory response following intratracheal instillation in murine lungs.

• DOI: 10.1016/j.toxlet.2015.11.006
• 发表时间: 2016-01-22
• 期刊: Toxicology letters
• 影响因子: 3.5
• 作者: Morris AS;Adamcakova-Dodd A;Lehman SE;Wongrakpanich A;Thorne PS;Larsen SC;Salem AK
• 通讯作者: Salem AK

Surface-modified particles loaded with CaMKII inhibitor protect cardiac cells against mitochondrial injury.

• DOI: 10.1016/j.ijpharm.2017.01.061
• 发表时间: 2017-03-30
• 期刊: International journal of pharmaceutics
• 影响因子: 5.8
• 作者: Wongrakpanich A;Morris AS;Geary SM;Joiner MA;Salem AK
• 通讯作者: Salem AK

Choline and geranic acid (CAGE) ionic liquids inhibit both elastase activity and growth of oral bacteria.

胆碱和香叶酸 (CAGE) 离子液体可抑制弹性蛋白酶活性和口腔细菌的生长。

• DOI: 10.1002/jbm.a.37485
• 发表时间: 2023
• 期刊: Journal of biomedical materials research. Part A
• 作者: Laird,NoahZ;Phruttiwanichakun,Pornpoj;Zhu,Min;Banas,JeffreyA;Elangovan,Satheesh;Salem,AliasgerK
• 通讯作者: Salem,AliasgerK

Fetal and neonatal maxillary ontogeny in extant humans and the utility of prenatal maxillary morphology in predicting ancestral affiliation.

现存人类的胎儿和新生儿上颌骨个体发育以及产前上颌骨形态在预测祖先关系中的效用。

• DOI: 10.1002/ajpa.23043
• 发表时间: 2016
• 期刊: American journal of physical anthropology
• 影响因子: 2.8
• 作者: Nicholas,ChristinaL

Parents and Provider Perspectives on the Return of Genomic Findings for Cleft Families in Africa.

父母和提供者对非洲裂隙家庭基因组发现返回的看法。

• DOI: 10.1080/23294515.2024.2302993
• 发表时间: 2024
• 期刊: AJOB empirical bioethics
• 作者: Oladayo,AbimbolaM;Prochaska,Sydney;Busch,Tamara;Adeyemo,WasiuL;Gowans,LordJJ;Eshete,Mekonen;Awotoye,Waheed;Sule,Veronica;Alade,Azeez;Adeyemo,AdebowaleA;Mossey,PeterA;Prince,Anya;Murray,JeffreyC;Butali,Azeez
• 通讯作者: Butali,Azeez