Secondary Analyses of Adolescent Caries, Including Fluoride, Diet & Other Factors

世纪后的理论确定了糖在龋齿病因学中的重要作用， 在氟化物的有益效果中，龋齿仍然是整个儿童时期的一种高度流行的疾病，包括 青春期青少年更大的独立性和经常接触含糖饮料（例如，苏打 流行病）似乎使他们比年轻时面临更大的风险。然而，这些龋齿发病率模式和 与危险因素的关系知之甚少，因为很少有关于龋齿发病率或风险的研究 青少年受试者中的因素。自1991年以来，使用出生时招募的队列，正在进行的爱荷华州氟化物 研究（IFS）全面评估了饮食数据与氟暴露之间的关系， 在5岁、9岁和13岁的个体中的龋齿。由于龋齿仍然是青少年的一种重要疾病， 这项研究提供了一个独特的机会来评估社会人口统计学，饮食，氟化物， 以及其他因素对13 ~ 17岁青少年龋齿发病率的影响。 本提案的主要目标是：1）对牙科模式进行详细的二次分析， 17岁恒牙列龋患率和13 ~ 17岁恒牙列龋患率; 检查13至17岁龋齿发病率（和17岁患病率）之间的关系， 饮食、氟化物、既往患龋经验和社会人口因素。多变量分析将评估 龋齿结果之间的关系和相互作用（发病率/增量和 患病率/计数）和不同饮食模式、口腔健康行为、氟化物 暴露、先前的龋齿经历、社会人口统计学和其他因素。然后我们将评估 我们关于13至17岁龋齿危险因素的研究结果与龋齿分析结果的一致性 5至9岁和9至13岁的早期风险因素。由于研究涉及招募和成功 从出生起就保持一个队列的情况是极其罕见的，爱荷华州氟化物研究提供了一个独特的研究机会， 这些关系在前所未有的细节，提高我们的能力，发展有效的青少年龋齿 预防方案。

A century after theories identified the prominent roles of sugars in dental caries etiology and the discovery of the beneficial effects of fluorides, caries remains a highly prevalent disease throughout childhood, including adolescence. Adolescents' greater independence and frequent exposure to sugared beverages (e.g., soda pop) appear to place them at greater risk than at younger ages. However, these caries incidence patterns and relationships with risk factors are poorly understood because there are few studies of caries incidence or risk factors among adolescent subjects. Since 1991, using a cohort recruited at birth, the ongoing Iowa Fluoride Study (IFS) has comprehensively assessed the relationships between dietary data and fluoride exposures and dental caries in individuals at ages 5, 9, and 13. As caries continues to be a significant disease in adolescents, the proposed study provides a unique opportunity to assess the effects of socio-demographic, dietary, fluoride, and other factors on the incidence of dental caries during adolescence from age 13 to 17 years in our cohort. The main objectives of this proposal are to 1) conduct detailed secondary analyses of patterns of dental caries of the permanent dentition at age 17 and caries incidence from 13 to 17, and 2) comprehensively examine the relationships among dental caries incidence from age 13 to 17 (and age 17 prevalence) and dietary, fluoride, prior caries experience, and socio-demographic factors. Multivariable analyses will assess the relationships between and interactions among caries outcomes (incidence/increments and prevalence/counts) and longitudinally-collected data on various dietary patterns, oral health behaviors, fluoride exposures, previous caries experience, socio-demographics, and other factors. We will then assess the consistency of our findings concerning caries risk factors for ages 13 to 17 with those from analyses of caries risk factors during earlier periods from ages 5 to 9 and 9 to 13. As studies involving recruitment and successful retention of a cohort from birth are extremely rare, the Iowa Fluoride Study offers a unique opportunity to study these relationships in unprecedented detail, enhancing our ability to develop effective adolescent caries prevention programs.