Investigation of Sleep
睡眠调查
基本信息
- 批准号:10761912
- 负责人:
- 金额:$ 32.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-01-07 至 2023-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
PROJECT SUMMARY / ABSTRACT: Investigation of Sleep in the Intensive Care Unit (ICU-SLEEP)
Sleep deprivation is among the most common complaints about the ICU experience. ICU sleep tends to be
light and non-restorative (as opposed to deep / restorative sleep), severely fragmented, and distributed
throughout the day and night rather than consolidated into nighttime hours. Sleep deprived patients suffer from
sleep debt, a condition of impaired attention and memory, and cognitive slowing. Sleep disturbances in the ICU
arise not only from light and noise pollution, but also from drugs that interfere with brain activity involved in
restorative sleep. Sleep deprivation has also been suggested as a major modifiable risk factors for acute
encephalopathy, also known as delirium. Delirium is an acute state of confusion that affects up to 80% of ICU
patients, and is one of six leading causes of preventable morbidity and mortality in hospitalized elderly patients.
Many patients who survive delirium experience long-term cognitive impairment and loss of independence.
Current medications used in the ICU to treat sleep problems (e.g. benzodiazepines, antipsychotics) do not
induce natural sleep and do not prevent delirium. In contrast, we have found that the α2-adrenoceptor agonist
dexmedetomidine can induce biomimetic sleep, a brain state whose pattern of electroencephalogram (EEG)
activity, cerebral blood flow, and functional connectivity approximates restorative sleep. Moreover, a recent
large clinical trial in post-surgical patients suggests that low-dose dexmedetomidine given overnight
substantially reduces the risk of delirium. It is unknown whether this benefit is linked to improved sleep, or
whether patients with better sleep while in the ICU have better long-term cognitive outcomes. Our central
hypothesis is that sleep deprivation substantially mediates both the short- and long-term cognitive impairments
associated with delirium in critical illness. To test this hypothesis, our specific aims are designed to
systematically determine 1) the impact of prophylactic dexmedetomidine on sleep quality, 2) the optimal way to
give dexmedetomidine (all night vs at the beginning of the night only), 2) the impact of sleep deprivation on
short-term cognitive function and delirium, and 3) the contribution of sleep deprivation to long-term
neuropsychiatric outcome following critical illness. At the conclusion of these studies, we will have expanded
our knowledge of sleep physiology in critical illness and relationship of sleep with delirium; evaluated a new
preemptive therapeutic strategy to promote sleep and prevent delirium, and developed an understanding of
how sleep impacts neuropsychological outcomes after critical illness. Our studies will thus will provide crucial
guidance for individualized approaches to preserving long-term brain health in this vulnerable patient
population.
项目摘要/摘要:重症监护病房(ICU-SLEEP)睡眠调查
项目成果
期刊论文数量(121)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Sample Size Analysis for Machine Learning Clinical Validation Studies.
- DOI:10.3390/biomedicines11030685
- 发表时间:2023-02-23
- 期刊:
- 影响因子:4.7
- 作者:
- 通讯作者:
CLASSIFIER CASCADE TO AID IN DETECTION OF EPILEPTIFORM TRANSIENTS IN INTERICTAL EEG.
分类器级联有助于检测间期脑电图中的癫痫样瞬变。
- DOI:10.1109/icassp.2018.8461992
- 发表时间:2018
- 期刊:
- 影响因子:0
- 作者:Bagheri,Elham;Jin,Jing;Dauwels,Justin;Cash,Sydney;Westover,MBrandon
- 通讯作者:Westover,MBrandon
Cost-effectiveness analysis of multimodal prognostication in cardiac arrest with EEG monitoring.
通过脑电图监测进行心脏骤停多模式预测的成本效益分析。
- DOI:10.1212/wnl.0000000000009916
- 发表时间:2020
- 期刊:
- 影响因子:9.9
- 作者:Amorim,Edilberto;Mo,ShirleyS;Palacios,Sebastian;Ghassemi,MohammadM;Weng,Wei-Hung;Cash,SydneyS;Bianchi,MatthewT;Westover,MBrandon
- 通讯作者:Westover,MBrandon
A Theoretical Paradigm for Evaluating Risk-Benefit of Status Epilepticus Treatment.
- DOI:10.1097/wnp.0000000000000753
- 发表时间:2020-09
- 期刊:
- 影响因子:0
- 作者:Amorim E;McGraw CM;Westover MB
- 通讯作者:Westover MB
ICU delirium burden predicts functional neurologic outcomes.
- DOI:10.1371/journal.pone.0259840
- 发表时间:2021
- 期刊:
- 影响因子:3.7
- 作者:Paixao L;Sun H;Hogan J;Hartnack K;Westmeijer M;Neelagiri A;Zhou DW;McClain LM;Kimchi EY;Purdon PL;Akeju O;Westover MB
- 通讯作者:Westover MB
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Michael Brandon Westover其他文献
Michael Brandon Westover的其他文献
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{{ truncateString('Michael Brandon Westover', 18)}}的其他基金
Big Data and Deep Learning for the Interictal-Ictal-Injury Contiuum
发作间期-发作期-损伤连续体的大数据和深度学习
- 批准号:
10761842 - 财政年份:2023
- 资助金额:
$ 32.52万 - 项目类别:
Data-Driven Sleep Biomarkers of Brain Health, Heart Health, and Mortality
数据驱动的大脑健康、心脏健康和死亡率的睡眠生物标志物
- 批准号:
10684096 - 财政年份:2022
- 资助金额:
$ 32.52万 - 项目类别:
Data-Driven Sleep Biomarkers of Brain Health, Heart Health, and Mortality
数据驱动的大脑健康、心脏健康和死亡率的睡眠生物标志物
- 批准号:
10758996 - 财政年份:2022
- 资助金额:
$ 32.52万 - 项目类别:
Big Data and Deep Learning for the Interictal-Ictal-Injury Continuum
发作间期-发作期-损伤连续体的大数据和深度学习
- 批准号:
10398908 - 财政年份:2018
- 资助金额:
$ 32.52万 - 项目类别:
Investigation of Sleep in the Intensive Care Unit (ICU-SLEEP)
重症监护病房睡眠调查(ICU-SLEEP)
- 批准号:
10372017 - 财政年份:2018
- 资助金额:
$ 32.52万 - 项目类别:
Big Data and Deep Learning for the Interictal-Ictal-Injury Continuum
发作间期-发作期-损伤连续体的大数据和深度学习
- 批准号:
9769180 - 财政年份:2018
- 资助金额:
$ 32.52万 - 项目类别:
Quantitative Monitoring and Control of Sedation and Pain in the ICU Environment
ICU 环境中镇静和疼痛的定量监测和控制
- 批准号:
8616877 - 财政年份:2014
- 资助金额:
$ 32.52万 - 项目类别:
Quantitative Monitoring and Control of Sedation and Pain in the ICU Environment
ICU 环境中镇静和疼痛的定量监测和控制
- 批准号:
9313343 - 财政年份:2014
- 资助金额:
$ 32.52万 - 项目类别:
Quantitative Monitoring and Control of Sedation and Pain in the ICU Environment
ICU 环境中镇静和疼痛的定量监测和控制
- 批准号:
8908065 - 财政年份:2014
- 资助金额:
$ 32.52万 - 项目类别:
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