A FAIR Bridge2AI Center (FABRIC)

Bridge 2AI：一个公平的AI桥中心（FABRIC）整体总结 我们建议建立一个FAIR Bridge 2AI中心（FABRIC），以组织一个大型联盟， 这些机构将生成数据和工具，以实现新型人工智能算法的应用 解决影响人类健康的生物医学或行为问题。我们中心的方法是 开发一个管理核心，与团队核心一起设计和管理 Bridge 2AI联盟的结构组件，专注于团队科学和包容性。 四个核心的产品和活动都由各自领域的专家领导， 他们在NIH资助的大型项目中有着广泛的合作记录，例如 BD 2K、All of Us等。行政和团队核心位于大学 加州圣地亚哥。由范德比尔特大学领导的道德核心将监督所有道德、法律的、 和社会影响（ELSI），制定指导方针并评估数据的公平性 发电项目（DGP）和其他财团产品。由大学领导的标准核心 得克萨斯州健康，将确保所有的产品和活动遵循公平（可找到，可访问， 可互操作、可重用）原则，并按照商定的标准进行协调/标准化。 由布罗德研究所领导的工具优化核心将利用其开发大型 扩展软件，为整个联盟建立一个平台，核心和DGP可以在其中 他们的产品可供其他研究人员使用。它还将优化各种工具， 对于Bridge 2AI很有用。技能和劳动力发展将开发和提供教育 为整个联合体提供材料和活动，并优化其他人开发的软件。一 FABRIC特别强调包容性，因为我们的愿景是建立一个新型的协调中心 在没有单个控制点的情况下以及在哪些事务（例如，数据访问、数据使用） 都不可更改地记录在一个易于访问的分类账中，所有人都可以查看。织物设计 使核心和DGP中的各种线程交织成一个持久的，可持续的中心， Bridge 2AI联盟

Bridge2AI: a FAIR AI BRIDGE Center (FABRIC) Overall Summary We propose to develop a FAIR Bridge2AI Center (FABRIC) to organize a large Consortium of institutions that will be generating data and tools to enable the application of novel AI algorithms to solve biomedical or behavioral problems affecting human health. Our center’s approach is to develop an Administrative Core that, together with a Teaming Core, designs and manages structural components of the Bridge2AI Consortium with a focus on team science and inclusion. The products and activities of each of four Cores are led by experts in their respective fields, and who have an extensive track record of working together in large NIH-funded initiatives, such as BD2K, All of Us, etc. The Administrative and Teaming Cores are based at the University of California San Diego. The Ethics Core, led by Vanderbilt University, will oversee all ethical, legal, and social implications (ELSI), generate guidelines and assess fairness in data from Data Generation Project (DGP) and other Consortium products. The Standards Core, led by University of Texas Health, will ensure that all products and activities follow the FAIR (findable, accessible, interoperable, reusable) principles and are harmonized/standardized to agreed upon standards. The Tool Optimization Core, led by the Broad Institute, will use its experience developing large- scale software to build a platform for the whole Consortium, where Cores and DGPs can have their products available for other researchers. It will also optimize various tools that are deemed useful for Bridge2AI. The Skills and Workforce Development will develop and deliver educational materials and activities for the whole consortium and optimize software developed by others. A special emphasis for FABRIC is inclusion, as our vision is for a novel type of Coordinating Center where there is no single point of control and in which transactions (e.g., data access, data use) are immutably recorded in an easy-to-access ledger that is viewable by all. FABRIC is designed so that various threads in Cores and DGPs are interwoven into a durable, sustainable center for the Bridge2AI Consortium.