Development of simulated 3-D virtual reality testing for baboon AD/dementia and spatial cognition research

开发针对狒狒 AD/痴呆症和空间认知研究的模拟 3D 虚拟现实测试

• 批准号: 10714469
• 负责人: Larry S. Schlesinger
• 金额: $ 50万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-06 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714469
• 关键词: 2019-nCoV; 3D virtual reality; Aging; Area; Back; Biomedical Research; Breeding; Callithrix; Caring; Cognition; Communicable Diseases; Communities; Data; Dementia; Development; Education and Outreach; Funding; Future; Goals; Health; Immunology; Infrastructure; Institution; Leadership; Macaca; Medicine; Metabolic Diseases; Mission; Neurosciences; Nonprofit Organizations; Outcome; Papio; Positioning Attribute; Primates; Privatization; Productivity; Publications; Reality Testing; Recording of previous events; Research; Research Institute; Research Personnel; Research Project Grants; Resources; Science; Scientist; Services; Structure; Students; Technology; Texas; Training; United States National Institutes of Health; Work; comparative; experience; human disease; human model; improved; innovation; nonhuman primate; programs; response; stem; success; translational medicine

OVERALL ABSTRACT The Mission of the Southwest National Primate Research Center (SNPRC) is to improve the health of our global community through innovative biomedical research with nonhuman primates (NHPs). One way that it achieves this goal is by serving as a global resource to scientists that can benefit from its expertise and nonhuman primate colonies. Texas Biomedical Research Institute (Texas Biomed), a private nonprofit research organization in San Antonio, TX, has a long history of performing biomedical research using NHPs dating back to the 1950s. Because of its success, Texas Biomed was chosen to host the Southwest National Primate Research Center in 1999. In doing so, SNPRC became the newest of the NIH funded National Primate Research Centers. This application for renewed NIH support of the SNPRC highlights the changes made in response to the reviews from the previous P51 renewal. Specifically, there have been several critical replacements and hires in leadership. In addition, SNPRC has restructured its internal research program into two Scientific Units to align with its expertise and future goals. The new Infectious Disease, Immunology and Control (IDIC) Scientific Unit represents research strengths developed over decades of primate-based research to bring greater emphasis to these areas. It is already taken advantage this Unit's expertise to become a leader in SARS-CoV-2 research. Meanwhile the Comparative Medicine and Health Outcomes (CMHO) Scientific Unit is positioned to be a leader in nonhuman primate research in recently emphasized research fields including metabolic disease, neuroscience, and aging. Both Scientific Units perform research with multiple species of primates including macaques, baboons and marmosets and are integrated into the overarching aims of the SNPRC which include research programs involving NHP models of human disease not available at other NPRCs. The SNPRC will continue to work towards its mission by i) To maintain healthy and well-characterized breeding and research colonies of several NHP (NHP) species for biomedical research, and to make them available to the scientific community; ii) To provide broad services in primate research to the national research community with an emphasis on specialized technologies and capabilities many of which are unique to the SNPRC. We provide these services to enhance collaborative opportunities to both internal and external investigators. Our expertise with diverse species of NHPs allows us to contribute ideas and perspectives about how best to accomplish the goals of research projects, thereby increasing the productivity and efficiency of the research, and strengthening the value of the data derived from it; iii) To maintain and to enhance the physical and administrative infrastructure of the NPRC so that it can best serve biomedical research. SNPRC has undergone significant changes in the Administrative structure in the past year. The benefits of these changes to efficiency and productivity are already apparent; iv) To advance training of staff, students, and visitors in the care and use of NHPs in biomedical research; v) To contribute to advances in science and translational medicine via publication of results obtained from research with NHPs and educational outreach to the public.

总体摘要 西南国家灵长类研究中心(SNPRC)的使命是改善我们人类的健康 通过对非人类灵长类动物(NHP)进行创新的生物医学研究，推动全球社会的发展。其中一种方法是 它通过为科学家提供全球资源来实现这一目标，这些科学家可以从它的专业知识和 非人灵长类动物群体。德克萨斯生物医学研究所(Texas Biomed)，一家私营非营利性组织 德克萨斯州圣安东尼奥的研究机构使用NHP进行生物医学研究已经有很长的历史了 可以追溯到20世纪50年代。因为它的成功，德克萨斯比默德被选为西南国家 1999年成立灵长类研究中心。在这样做的过程中，SNPRC成为NIH资助的最新国家 灵长类研究中心。这次申请国家卫生研究院对SNPRC的重新支持突出了这些变化 是对上次更新P51页的审查作出的回应。具体地说，有几个 关键的领导层更替和招聘。此外，SNPRC还调整了其内部研究 计划分为两个科学单位，以与其专业知识和未来目标保持一致。新的传染病， 免疫学和控制(IDIC)科学单位代表了几十年来发展起来的研究实力 以灵长类为基础的研究，使这些领域得到更大的重视。它已经利用了这个单位的 成为SARS-CoV-2研究的领先者的专业知识。同时，比较医学与健康 结果(CMHO)科学部最近被定位为非人类灵长类研究的领导者 重点研究领域包括代谢性疾病、神经科学和衰老。两个科学单位 对多种灵长类动物进行研究，包括猕猴、狒狒和绒猴，并 纳入SNPRC的总体目标，其中包括涉及NHP模型的研究计划 其他国家疾病控制中心没有的人类疾病。SNPRC将继续朝着i)的使命努力) 保持几个NHP(NHP)物种的健康和良好特性的繁育和研究群体 用于生物医学研究，并将其提供给科学界；ii)提供广泛的 为国家研究界提供灵长类研究方面的服务，重点是专门的 技术和能力，其中许多是SNPRC独有的。我们为以下客户提供这些服务 增加内部和外部调查人员的合作机会。我们的专业知识包括 NHP的种类使我们能够就如何最好地实现以下目标提供想法和观点 研究项目，从而提高研究的生产力和效率，并加强 数据的价值；三)维持和加强实体和行政 为NPRC提供基础设施，以使其能够最好地为生物医学研究服务。SNPRC经历了意义重大的 在过去的一年里，行政结构的变化。这些变化对效率和 生产力已经显现；iv)推进对工作人员、学生和访客的护理和使用方面的培训 生物医学研究中的NHP；v)通过以下方式促进科学和转化医学的进步 出版与国家卫生计划的研究成果，并向公众进行教育宣传。