Stress and Resilience in the VIP

VIP 的压力和弹性

• 批准号: 10726451
• 负责人: OANH L MEYER
• 金额: $ 40.1万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10726451
• 关键词: Acculturation; Address; Administrative Supplement; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Area; Asian Americans; Attenuated; Biological Markers; Blood; C-reactive protein; California; Cardiovascular Diseases; Cardiovascular system; Cognition; Cognitive; Cognitive aging; Cohort Studies; Collection; Communities; Complement; County; Data; Data Collection; Data Set; Dementia; Development; Disease; Disparity population; Elderly; Ethnic Population; Exposure to; Funding; Goals; Grant; Human Resources; Immigration; Impaired cognition; Individual; Knowledge; Latino; Life; Life Cycle Stages; Lipids; Longitudinal Studies; Measures; Mental Depression; Modeling; Natural experiment; Outcome; Participant; Patient Self-Report; Pattern; Population; Post-Traumatic Stress Disorders; Questionnaires; Race; Reporting; Research; Resources; Risk; Risk Factors; Role; San Francisco; Stress; Time; Trauma; Vietnamese; Visit; War; aged; cardiovascular disorder risk; cardiovascular health; cognitive function; cohort; dementia risk; early life adversity; experience; fasting glucose; inflammatory marker; innovation; insight; low socioeconomic status; migration; mild cognitive impairment; parent grant; perceived stress; programs; racial minority population; resilience; resilience factor; social culture; sociocultural determinant; trauma exposure

Asian Americans are the fastest growing racial minority group in the U.S and yet there is a dearth of research on their cognitive aging and risks for Alzheimer's disease and related dementias (ADRD). This is especially true for Vietnamese Americans, the 4th largest Asian American group in the U.S. Vietnamese Americans suffer disproportionately from early life adversity and trauma, depression, stress, and low socioeconomic status (SES), all of which may increase risk for cognitive impairment and development of dementia. The specific sociocultural context of this group (i.e., high exposure to trauma, stress, diverse acculturation and immigration patterns) provides a unique opportunity to examine how early life factors and sociocultural diversity impact cognitive outcomes. In this supplement application, Stress and Resilience in the VIP (parent grant: Vietnamese Insights into Cognitive Aging Program (VIP), R01AG067541), we will build on this unprecedented cohort study by collecting additional and innovative data. The overall goal of the parent grant is to obtain preliminary estimates of mild cognitive impairment and dementia in the community and identify ADRD risk and resilience factors in this understudied group. For this supplement, we propose the following: Aim 1: Obtain measures of stress and resilience in VIP participants at their Time 2 visit. We will add two additional measures not yet captured in the grant but are important within the context of cognitive aging for Vietnamese Americans– perceived stress and resilience, and hs-CRP will be added to the blood draw (N = 540). Aim 2. Examine the associations between stress, trauma, and adversity. We hypothesize that those with increased levels of perceived stress and hs-CRP at Time 2 will have reported higher levels of trauma and adversity at the Time 1 visit. Aim 3. Examine the associations between new measures and cognition. We hypothesize that those with elevated levels of perceived stress and hs- CRP will have lower cross-sectional cognition scores, and this relationship will be attenuated by higher resilience scores. This proposal contributes new research to an unmatched longitudinal study whose findings will lead to a better understanding of cognitive aging and mechanisms of disease in an understudied group but also have broader implications for advancing our knowledge of the sociocultural and early life contributions to cognitive aging in other populations.

亚裔美国人是美国增长最快的少数族裔群体，但却缺乏 研究他们的认知老化与阿尔茨海默病和相关痴呆(ADRD)的风险。这 越南裔美国人尤其如此，他们是美国第四大亚裔美国人群体。 越南裔美国人早年遭受的逆境和创伤、抑郁、 压力和低社会经济地位，所有这些都可能增加认知障碍的风险 和痴呆症的发展。这一群体的特定社会文化背景(即，高度接触 创伤、压力、多元文化适应和移民模式)提供了一个独特的机会 研究早期生活因素和社会文化多样性如何影响认知结果。在本增刊中 VIP中的应用、压力和弹性(家长津贴：越南人对认知老龄化的洞察 计划(VIP)，R01AG067541)，我们将在这项史无前例的队列研究的基础上收集 额外和创新的数据。家长赠款的总体目标是获得以下项目的初步估计 社区中轻度认知障碍和痴呆症，并确定ADRD风险和复原力因素 在这个未被研究的群体中。对于这一补编，我们提出如下建议：目标1：获得 VIP参与者在他们访问的时间2的压力和韧性。我们将增加两项额外措施 尚未包括在拨款中，但在越南人认知老化的背景下很重要 美国人-感受到的压力和韧性，hs-CRP将被添加到抽血中(N=540)。 目的2.研究压力、创伤和逆境之间的联系。我们假设 那些在时间2感觉到压力和hs-crp水平增加的人将报告更高的水平。 一次访问时的创伤和逆境。目标3.研究新技术与新技术之间的关联 测量和认知。我们假设那些感觉到压力和hs水平升高的人- C反应蛋白将具有较低的横断面认知分数，并且这种关系将被较高的分数衰减 复原力得分。这一提议为一项无与伦比的纵向研究贡献了新的研究成果，该研究 这些发现将有助于更好地理解认知老化和老年痴呆症的发病机制。 研究不足的群体，但也有更广泛的影响，以促进我们的社会文化知识 在其他人群中，早期生活对认知老化的贡献。