Stress and Resilience in the VIP

VIP 的压力和弹性

• 批准号: 10726451
• 负责人: OANH L MEYER
• 金额: $ 40.1万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10726451
• 关键词: Acculturation; Address; Administrative Supplement; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Area; Asian Americans; Attenuated; Biological Markers; Blood; C-reactive protein; California; Cardiovascular Diseases; Cardiovascular system; Cognition; Cognitive; Cognitive aging; Cohort Studies; Collection; Communities; Complement; County; Data; Data Collection; Data Set; Dementia; Development; Disease; Disparity population; Elderly; Ethnic Population; Exposure to; Funding; Goals; Grant; Human Resources; Immigration; Impaired cognition; Individual; Knowledge; Latino; Life; Life Cycle Stages; Lipids; Longitudinal Studies; Measures; Mental Depression; Modeling; Natural experiment; Outcome; Participant; Patient Self-Report; Pattern; Population; Post-Traumatic Stress Disorders; Questionnaires; Race; Reporting; Research; Resources; Risk; Risk Factors; Role; San Francisco; Stress; Time; Trauma; Vietnamese; Visit; War; aged; cardiovascular disorder risk; cardiovascular health; cognitive function; cohort; dementia risk; early life adversity; experience; fasting glucose; inflammatory marker; innovation; insight; low socioeconomic status; migration; mild cognitive impairment; parent grant; perceived stress; programs; racial minority population; resilience; resilience factor; social culture; sociocultural determinant; trauma exposure

Asian Americans are the fastest growing racial minority group in the U.S and yet there is a dearth of research on their cognitive aging and risks for Alzheimer's disease and related dementias (ADRD). This is especially true for Vietnamese Americans, the 4th largest Asian American group in the U.S. Vietnamese Americans suffer disproportionately from early life adversity and trauma, depression, stress, and low socioeconomic status (SES), all of which may increase risk for cognitive impairment and development of dementia. The specific sociocultural context of this group (i.e., high exposure to trauma, stress, diverse acculturation and immigration patterns) provides a unique opportunity to examine how early life factors and sociocultural diversity impact cognitive outcomes. In this supplement application, Stress and Resilience in the VIP (parent grant: Vietnamese Insights into Cognitive Aging Program (VIP), R01AG067541), we will build on this unprecedented cohort study by collecting additional and innovative data. The overall goal of the parent grant is to obtain preliminary estimates of mild cognitive impairment and dementia in the community and identify ADRD risk and resilience factors in this understudied group. For this supplement, we propose the following: Aim 1: Obtain measures of stress and resilience in VIP participants at their Time 2 visit. We will add two additional measures not yet captured in the grant but are important within the context of cognitive aging for Vietnamese Americans– perceived stress and resilience, and hs-CRP will be added to the blood draw (N = 540). Aim 2. Examine the associations between stress, trauma, and adversity. We hypothesize that those with increased levels of perceived stress and hs-CRP at Time 2 will have reported higher levels of trauma and adversity at the Time 1 visit. Aim 3. Examine the associations between new measures and cognition. We hypothesize that those with elevated levels of perceived stress and hs- CRP will have lower cross-sectional cognition scores, and this relationship will be attenuated by higher resilience scores. This proposal contributes new research to an unmatched longitudinal study whose findings will lead to a better understanding of cognitive aging and mechanisms of disease in an understudied group but also have broader implications for advancing our knowledge of the sociocultural and early life contributions to cognitive aging in other populations.

亚裔美国人是美国增长最快的少数族裔群体，然而， 研究他们的认知老化和患阿尔茨海默病和相关痴呆症（ADRD）的风险。这 尤其是越南裔美国人，美国第四大亚裔美国人群体。 越南裔美国人遭受不成比例的早期生活逆境和创伤，抑郁症， 压力和低社会经济地位（SES），所有这些都可能增加认知障碍的风险 和痴呆症的发展。这一群体的具体社会文化背景（即，高度暴露于 创伤、压力、不同的文化适应和移民模式）提供了一个独特的机会， 研究早期生活因素和社会文化多样性如何影响认知结果。在增刊中 应用程序，压力和弹性在VIP（家长资助：越南洞察认知老化 计划（VIP），R 01 AG 067541），我们将通过收集 额外且创新的数据。父母补助金的总体目标是获得 社区中的轻度认知障碍和痴呆症，并确定ADRD风险和恢复力因素 在这个未被充分研究的群体中。对于这一补充，我们提出以下建议：目标1： VIP参与者在时间2访视时的压力和恢复力。我们将增加两项额外措施 尚未在赠款中获得，但在越南认知老化的背景下很重要 美国人-感知的压力和弹性，hs-CRP将被添加到抽血（N = 540）。 目标2.检查压力，创伤和逆境之间的联系。我们假设 那些在时间2感觉到压力和hs-CRP水平升高的人将报告更高的水平 创伤和逆境的影响。目标3.检查新的 措施和认知。我们假设那些感知压力水平升高的人- CRP将具有较低的横断面认知评分，并且这种关系将被较高的 韧性得分这一建议为一项无与伦比的纵向研究提供了新的研究， 研究结果将有助于更好地了解认知老化和疾病的机制， 这是一个未被充分研究的群体，但也对提高我们对社会文化的认识有更广泛的影响。 以及其他人群中早期生命对认知老化的贡献。