Vietnamese Insights into Cognitive Aging Program (VIP)

越南认知衰老洞察计划（VIP）

• 批准号: 10350628
• 负责人: OANH L MEYER
• 金额: $ 145.69万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10350628
• 关键词: Acculturation; Address; Adult; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Asian Americans; Asian population; Attenuated; Biological; Black Populations; California; Cardiovascular Diseases; Childhood; Chinese; Cognition; Cognitive; Cognitive aging; Communities; Data; Dementia; Disease; English Language; Enrollment; Ethnic group; Exposure to; Family Caregiver; Goals; Health; Health Disparities Research; High Prevalence; Immigrant; Immigration; Impaired cognition; Impairment; Individual; Intervention; Knowledge; Latino Population; Life; Life Cycle Stages; Longitudinal Studies; Mediating; Mental Depression; Modeling; Neighborhoods; Not Hispanic or Latino; Outcome; Pathway interactions; Pattern; Population; Post-Traumatic Stress Disorders; Prevalence; Prevention; Process; Race; Research; Risk; Risk Factors; Role; San Francisco; Social support; Socioeconomic Status; Subgroup; Trauma; Underserved Population; United States; Universities; War; Woman; Work; aged; base; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; cognitive development; cognitive function; cohesion; cohort; community partnership; dementia risk; early life adversity; ethnic diversity; experience; health disparity; innovation; insight; low socioeconomic status; men; mild cognitive impairment; novel; physical inactivity; post-traumatic stress; programs; prospective; protective factors; public health relevance; racial and ethnic; racial minority population; recruit; resilience; sex; smoking prevalence; social culture; social factors; southeast Asian; supportive environment; theories; trauma exposure

Asian Americans are the fastest growing racial minority group in the U.S and yet there is a dearth of research on their cognitive aging and risks for Alzheimer's disease and related dementias (ADRD). This is especially true for Vietnamese Americans, the largest Southeast Asian group in the U.S. Vietnamese Americans suffer disproportionately from early life adversity and trauma, depression, and low socioeconomic status (SES), all of which may increase risk for cognitive impairment and development of dementia. The specific sociocultural context of this group (i.e., high exposure to trauma, post-traumatic stress, diverse acculturation and immigration patterns) provides a unique opportunity to examine how early life factors and sociocultural diversity impact cognitive outcomes. In this R01 application, Vietnamese Insights into Cognitive Aging Program (VIP), we will develop an unprecedented longitudinal study of older Vietnamese Americans to begin addressing the dearth of cognitive aging research in this population. The overall goal is to obtain preliminary estimates of mild cognitive impairment and dementia in the community and identify ADRD risk and resilience factors in this understudied group. Using the NIA health disparities research framework as a model, we propose the following: Aim 1: Characterize longitudinal cognitive function and ADRD risk in a community-based cohort of 540 older Vietnamese aged 65+ living in Northern California. Aim 2a: Examine the role of adversity and trauma on ADRD risk in older Vietnamese. Aim 2b: Evaluate the influence of current sociocontextual factors on ADRD risk in older Vietnamese. Aim 3: Determine the role of cardiovascular disease and health risk factors on cognition in older Vietnamese. In the process of studying these important risk and protective factors, we will engage a population that is severely missing from aging research and contribute to theory on the role of adversity, trauma, and sociocultural diversity on dementia risk. This study will leverage an older Vietnamese population with which we already have strong community partnerships to create an unmatched longitudinal study. Findings will lead to a better understanding of cognitive aging and mechanisms of disease in this understudied group but also have broader implications for advancing our knowledge of the sociocultural and early life contributions to cognitive aging in other populations.

亚裔美国人是美国增长最快的少数族裔群体，但缺乏研究 关于他们的认知老化和阿尔茨海默病和相关痴呆(ADRD)的风险。这是特别的 对于美国最大的东南亚群体越南裔美国人来说是如此。越南裔美国人遭受 不成比例地来自早年的生活逆境和创伤、抑郁和低社会经济地位(SES)，所有这些 这可能会增加认知障碍和痴呆症的风险。特定的社会文化 这一群体的背景(即，高度暴露于创伤、创伤后应激、多元文化适应和 移民模式)提供了一个独特的机会来研究早期生活因素和社会文化多样性 影响认知结果。在此R01应用程序中，越南认知老化洞察计划(VIP)、 我们将对老年越南裔美国人进行一项史无前例的纵向研究，以开始解决 在这一人群中缺乏认知老化的研究。总体目标是获得轻度的初步估计 社区中的认知障碍和痴呆症，并确定ADRD的风险和复原力因素 未被研究的群体。以NIA健康差距研究框架为模型，我们提出了 以下：目标1：在一个基于社区的队列中描述纵向认知功能和ADRD风险 居住在加利福尼亚州北部的540名65岁以上的越南老年人。目标2a：审查逆境和创伤的作用 关于老年越南人的ADRD风险。目标2b：评估当前社会背景因素对ADRD的影响 老年越南语中的风险。目标3：确定心血管疾病和健康风险因素在 老年越南语的认知能力。在研究这些重要的风险和保护因素的过程中，我们将 让老龄化研究中严重缺失的人群参与进来，并为关于 逆境、创伤和社会文化多样性对痴呆症风险的影响。这项研究将利用一位年长的越南人 我们已经与之建立了强大的社区合作伙伴关系，以创造无与伦比的纵向 学习。这些发现将有助于更好地理解认知老化和这一疾病的发病机制 研究不足的群体，但也有更广泛的影响，以促进我们的社会文化和 在其他人群中，早期生活对认知老化的贡献。