Vietnamese Insights into Cognitive Aging Program (VIP)

亚裔美国人是美国增长最快的少数族裔群体，但缺乏研究 认知老化和阿尔茨海默病及相关痴呆症（ADRD）的风险。这是特别 越南裔美国人是美国最大的东南亚群体， 不成比例地来自早期生活的逆境和创伤，抑郁症和低社会经济地位（SES），所有 这可能会增加认知障碍和痴呆症发展的风险。具体的社会文化 该组的上下文（即，高度暴露于创伤、创伤后压力、多样化的文化适应， 移民模式）提供了一个独特的机会，研究如何早期生活因素和社会文化多样性 影响认知结果。在这个R01应用程序，越南洞察认知老化计划（VIP）， 我们将对年长的越南裔美国人开展一项前所未有的纵向研究，开始解决 缺乏对这一人群的认知老化研究。总体目标是获得轻度 认知障碍和痴呆症的社区，并确定ADRD的风险和弹性因素， 替补组使用NIA健康差异研究框架作为模型，我们提出了 目的1：描述以社区为基础的队列中的纵向认知功能和ADRD风险， 居住在北方加州的540名65岁以上的越南老年人。目标2a：考察逆境和创伤的作用 老年越南人的ADRD风险。目标2b：评价当前社会背景因素对ADRD的影响 越南老人的风险目的3：确定心血管疾病和健康危险因素对 老越南人的认知在研究这些重要的风险和保护因素的过程中， 从事人口是严重缺乏老龄化研究，并有助于理论的作用， 逆境、创伤和社会文化多样性对痴呆风险的影响。这项研究将利用一个年长的越南人 我们已经拥有强大的社区合作伙伴关系， study.研究结果将有助于更好地了解认知老化和疾病的机制， 研究不足的群体，但也有更广泛的影响，促进我们的社会文化知识， 早期生活对其他人群认知老化的贡献。

Asian Americans are the fastest growing racial minority group in the U.S and yet there is a dearth of research on their cognitive aging and risks for Alzheimer's disease and related dementias (ADRD). This is especially true for Vietnamese Americans, the largest Southeast Asian group in the U.S. Vietnamese Americans suffer disproportionately from early life adversity and trauma, depression, and low socioeconomic status (SES), all of which may increase risk for cognitive impairment and development of dementia. The specific sociocultural context of this group (i.e., high exposure to trauma, post-traumatic stress, diverse acculturation and immigration patterns) provides a unique opportunity to examine how early life factors and sociocultural diversity impact cognitive outcomes. In this R01 application, Vietnamese Insights into Cognitive Aging Program (VIP), we will develop an unprecedented longitudinal study of older Vietnamese Americans to begin addressing the dearth of cognitive aging research in this population. The overall goal is to obtain preliminary estimates of mild cognitive impairment and dementia in the community and identify ADRD risk and resilience factors in this understudied group. Using the NIA health disparities research framework as a model, we propose the following: Aim 1: Characterize longitudinal cognitive function and ADRD risk in a community-based cohort of 540 older Vietnamese aged 65+ living in Northern California. Aim 2a: Examine the role of adversity and trauma on ADRD risk in older Vietnamese. Aim 2b: Evaluate the influence of current sociocontextual factors on ADRD risk in older Vietnamese. Aim 3: Determine the role of cardiovascular disease and health risk factors on cognition in older Vietnamese. In the process of studying these important risk and protective factors, we will engage a population that is severely missing from aging research and contribute to theory on the role of adversity, trauma, and sociocultural diversity on dementia risk. This study will leverage an older Vietnamese population with which we already have strong community partnerships to create an unmatched longitudinal study. Findings will lead to a better understanding of cognitive aging and mechanisms of disease in this understudied group but also have broader implications for advancing our knowledge of the sociocultural and early life contributions to cognitive aging in other populations.