Vietnamese Insights into Cognitive Aging Program (VIP)

越南认知衰老洞察计划（VIP）

基本信息

批准号：
10551834
负责人：
OANH L MEYER
金额：
$ 145.69万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-15 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10551834
关键词：
Acculturation Address Adult Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk American Asian Americans Asian population Attenuated Biological Black Populations California Cardiovascular Diseases Childhood Chinese Cognition Cognitive Cognitive aging Communities Data Dementia Development Disease Disparity population English Language Enrollment Ethnic Origin Ethnic Population Exposure to Family Caregiver Goals Health Health Disparities Research High Prevalence Immigrant Immigration Impaired cognition Impairment Individual Intervention Knowledge Latino Population Life Life Cycle Stages Longitudinal Studies Mediating Mental Depression Modeling Neighborhoods Not Hispanic or Latino Outcome Pathway interactions Pattern Population Post-Traumatic Stress Disorders Prevalence Prevention Process Race Research Risk Risk Factors Role San Francisco Social support Socioeconomic Status Subgroup Trauma Underserved Population United States Universities Vietnamese War Woman Work aged cardiovascular disorder risk cardiovascular health cardiovascular risk factor cognitive function cohesion cohort community partnership dementia risk early life adversity ethnic diversity experience health disparity innovation insight low socioeconomic status men mild cognitive impairment novel physical inactivity post-traumatic stress programs prospective protective factors public health relevance racial diversity racial minority population racial population recruit resilience resilience factor sex smoking prevalence social culture social factors southeast Asian supportive environment theories trauma exposure

项目摘要

Asian Americans are the fastest growing racial minority group in the U.S and yet there is a dearth of research on their cognitive aging and risks for Alzheimer's disease and related dementias (ADRD). This is especially true for Vietnamese Americans, the largest Southeast Asian group in the U.S. Vietnamese Americans suffer disproportionately from early life adversity and trauma, depression, and low socioeconomic status (SES), all of which may increase risk for cognitive impairment and development of dementia. The specific sociocultural context of this group (i.e., high exposure to trauma, post-traumatic stress, diverse acculturation and immigration patterns) provides a unique opportunity to examine how early life factors and sociocultural diversity impact cognitive outcomes. In this R01 application, Vietnamese Insights into Cognitive Aging Program (VIP), we will develop an unprecedented longitudinal study of older Vietnamese Americans to begin addressing the dearth of cognitive aging research in this population. The overall goal is to obtain preliminary estimates of mild cognitive impairment and dementia in the community and identify ADRD risk and resilience factors in this understudied group. Using the NIA health disparities research framework as a model, we propose the following: Aim 1: Characterize longitudinal cognitive function and ADRD risk in a community-based cohort of 540 older Vietnamese aged 65+ living in Northern California. Aim 2a: Examine the role of adversity and trauma on ADRD risk in older Vietnamese. Aim 2b: Evaluate the influence of current sociocontextual factors on ADRD risk in older Vietnamese. Aim 3: Determine the role of cardiovascular disease and health risk factors on cognition in older Vietnamese. In the process of studying these important risk and protective factors, we will engage a population that is severely missing from aging research and contribute to theory on the role of adversity, trauma, and sociocultural diversity on dementia risk. This study will leverage an older Vietnamese population with which we already have strong community partnerships to create an unmatched longitudinal study. Findings will lead to a better understanding of cognitive aging and mechanisms of disease in this understudied group but also have broader implications for advancing our knowledge of the sociocultural and early life contributions to cognitive aging in other populations.

亚裔美国人是美国增长最快的种族少数群体，但缺乏研究关于阿尔茨海默氏病和相关痴呆症（ADRD）的认知衰老和风险。尤其是对越南美国人，美国越南最大的东南亚群体遭受的苦难是正确的从早期的逆境和创伤，抑郁和低社会经济地位（SES）中不成比例这可能会增加痴呆症认知障碍和发展的风险。特定的社会文化该群体的背景（即高暴露于创伤，创伤后压力，多样化的适应和移民模式）提供了一个独特的机会来研究早期生活因素和社会文化多样性影响认知结果。在此R01应用程序中，越南对认知衰老计划（VIP）的见解，我们将对越南较老的美国人进行前所未有的纵向研究，以开始解决缺乏该人群的认知衰老研究。总体目标是获得轻度的初步估计社区中的认知障碍和痴呆症，并确定ADRD的风险和弹性因素研究的群体。将NIA健康差异研究框架作为模型，我们提出以下：AIM 1：在基于社区的队列中表征纵向认知功能和ADRD风险 540名越南年龄在加利福尼亚北部的65岁以上的越南人。目标2a：检查逆境和创伤的作用越南较老的风险。 AIM 2B：评估当前社会上下文因素对ADRD的影响越南老年人的风险。目标3：确定心血管疾病和健康危险因素对越南老年人的认知。在研究这些重要风险和保护因素的过程中，我们将吸引人口在衰老研究中严重缺失，并为理论做出理论痴呆症风险的逆境，创伤和社会文化多样性。这项研究将利用较早的越南人我们已经建立了强大的社区伙伴关系来创建无与伦比的纵向学习。发现将使人们更好地理解疾病的认知衰老和机制研究了群体，但也对我们对社会文化的了解有了更广泛的影响早期生活对其他人群认知衰老的贡献。