Vietnamese Insights into Cognitive Aging Program (VIP)

越南认知衰老洞察计划（VIP）

• 批准号: 10551834
• 负责人: OANH L MEYER
• 金额: $ 145.69万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10551834
• 关键词: Acculturation; Address; Adult; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Asian Americans; Asian population; Attenuated; Biological; Black Populations; California; Cardiovascular Diseases; Childhood; Chinese; Cognition; Cognitive; Cognitive aging; Communities; Data; Dementia; Development; Disease; Disparity population; English Language; Enrollment; Ethnic Origin; Ethnic Population; Exposure to; Family Caregiver; Goals; Health; Health Disparities Research; High Prevalence; Immigrant; Immigration; Impaired cognition; Impairment; Individual; Intervention; Knowledge; Latino Population; Life; Life Cycle Stages; Longitudinal Studies; Mediating; Mental Depression; Modeling; Neighborhoods; Not Hispanic or Latino; Outcome; Pathway interactions; Pattern; Population; Post-Traumatic Stress Disorders; Prevalence; Prevention; Process; Race; Research; Risk; Risk Factors; Role; San Francisco; Social support; Socioeconomic Status; Subgroup; Trauma; Underserved Population; United States; Universities; Vietnamese; War; Woman; Work; aged; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; cognitive function; cohesion; cohort; community partnership; dementia risk; early life adversity; ethnic diversity; experience; health disparity; innovation; insight; low socioeconomic status; men; mild cognitive impairment; novel; physical inactivity; post-traumatic stress; programs; prospective; protective factors; public health relevance; racial diversity; racial minority population; racial population; recruit; resilience; resilience factor; sex; smoking prevalence; social culture; social factors; southeast Asian; supportive environment; theories; trauma exposure

Asian Americans are the fastest growing racial minority group in the U.S and yet there is a dearth of research on their cognitive aging and risks for Alzheimer's disease and related dementias (ADRD). This is especially true for Vietnamese Americans, the largest Southeast Asian group in the U.S. Vietnamese Americans suffer disproportionately from early life adversity and trauma, depression, and low socioeconomic status (SES), all of which may increase risk for cognitive impairment and development of dementia. The specific sociocultural context of this group (i.e., high exposure to trauma, post-traumatic stress, diverse acculturation and immigration patterns) provides a unique opportunity to examine how early life factors and sociocultural diversity impact cognitive outcomes. In this R01 application, Vietnamese Insights into Cognitive Aging Program (VIP), we will develop an unprecedented longitudinal study of older Vietnamese Americans to begin addressing the dearth of cognitive aging research in this population. The overall goal is to obtain preliminary estimates of mild cognitive impairment and dementia in the community and identify ADRD risk and resilience factors in this understudied group. Using the NIA health disparities research framework as a model, we propose the following: Aim 1: Characterize longitudinal cognitive function and ADRD risk in a community-based cohort of 540 older Vietnamese aged 65+ living in Northern California. Aim 2a: Examine the role of adversity and trauma on ADRD risk in older Vietnamese. Aim 2b: Evaluate the influence of current sociocontextual factors on ADRD risk in older Vietnamese. Aim 3: Determine the role of cardiovascular disease and health risk factors on cognition in older Vietnamese. In the process of studying these important risk and protective factors, we will engage a population that is severely missing from aging research and contribute to theory on the role of adversity, trauma, and sociocultural diversity on dementia risk. This study will leverage an older Vietnamese population with which we already have strong community partnerships to create an unmatched longitudinal study. Findings will lead to a better understanding of cognitive aging and mechanisms of disease in this understudied group but also have broader implications for advancing our knowledge of the sociocultural and early life contributions to cognitive aging in other populations.

亚裔美国人是美国增长最快的少数种族群体，但却缺乏相关研究