Emotion regulation in depression: neural bases of reappraisal

抑郁症的情绪调节：重新评估的神经基础

• 批准号: 7611372
• 负责人: DANIEL G DILLON
• 金额: $ 4.99万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7611372
• 关键词: Accounting; Address; Affect; Affective; Amygdaloid structure; Anhedonia; Anterior; Arousal; Behavioral; Brain; Clinical; Cognitive; Collection; Condition; Conflict (Psychology); Confounding Factors (Epidemiology); Data; Depressed mood; Desire for food; Diagnosis; Disease; Dorsal; Electroencephalogram; Electromagnetics; Electromyography; Electrophysiology (science); Emotional; Emotions; Face; Failure; Feeling; Feeling hopeless; Frequencies; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Guilt; Heterogeneity; Imagery; Individual; Lateral; Lead; Left; Literature; Magnetic Resonance Imaging; Major Depressive Disorder; Mediating; Memory; Mental Depression; Methods; Modeling; Parietal; Participant; Patient Self-Report; Patients; Pattern; Performance; Physiology; Plan B; Prefrontal Cortex; Process; Productivity; Public Health; Range; Rate; Relative (related person); Research; Research Personnel; Research Training; Resolution; Role; Severities; Short-Term Memory; Sleep Disorders; Societies; Staging; Stimulus; Symptoms; System; Techniques; Testing; Variant; Visual attention; Work; base; cingulate cortex; cognitive function; cost; density; depressive symptoms; design; emotion regulation; gaze; improved; insight; mental imagery; neural circuit; psychologic; relating to nervous system; research study; response; spatiotemporal; success

DESCRIPTION (provided by applicant): Major Depressive Disorder (MDD) is a debilitating condition that places a significant burden on individuals and society. For individuals, MDD is associated with a range of symptoms, including feelings of hopelessness and guilt and extending to anhedonia, apathy, disturbances in appetite and sleep, and problems with concentration and memory. For society, the/burden of MDD is manifested in lost productivity and in significant costs associated with treatment. The heterogeneity of symptoms associated with depression presents a challenge to both researchers trying to understand the disorder and clinicians trying to treat it. However, two separate lines of research suggest a straightforward hypothesis: multiple aspects of depressive illness may fundamentally be a consequence of dysfunction in neural systems implicated in emotion regulation. First, research examining baseline neural activity and performance on cognitive tasks demonstrates that depression is associated with dysfunction in neural regions such as the prefrontal cortex (PFC), anterior cingulate cortex (ACC), and amygdala. Second, research with healthy participants shows that these same neural regions are directly implicated in emotion regulation. This proposal describes two experiments designed to integrate these lines of research. In both experiments, participants will attempt to regulate their responses to emotionally negative stimuli using reappraisal, an adaptive emotion regulation strategy supported by cortico-cingulate-amygdalar interactions. Electroencephalogram (EEG; Exp. 1) and functional magnetic resonance imaging (fMRI; Exp. 2) data will be collected during reappraisal attempts made by patients with MDD and healthy controls. In combination, the EEG and fMRI data will be used to generate a detailed spatiotemporal model of the brain mechanisms underlying reappraisal. These data will also be used to test the hypothesis that failures of emotion regulation in MDD are associated with dysfunction in specific neural regions, including lateral PFC, dorsal ACC, and the amygdala. PUBLIC HEALTH RELEVANCE: By identifying a core process-emotion regulation-implicated in depression and tying emotion regulation failures to dysfunction in specific neural circuits, the proposed studies will help clarify the pathophysiology of depression. Ultimately, this approach might contribute to improvements in diagnosis and treatment.

描述（由申请人提供）：重度抑郁症（MDD）是一种使人衰弱的疾病，给个人和社会带来了沉重的负担。对于个体而言，重度抑郁症与一系列症状相关，包括绝望感和内疚感，并延伸到快感缺乏、冷漠、食欲和睡眠障碍，以及注意力和记忆力问题。对社会而言，重度抑郁症的负担表现为生产力损失和与治疗相关的巨额费用。抑郁症相关症状的异质性对试图理解这种疾病的研究人员和试图治疗它的临床医生都提出了挑战。然而，两个独立的研究方向提出了一个简单的假设：抑郁症的多个方面可能从根本上说是与情绪调节有关的神经系统功能障碍的结果。首先，对认知任务的基线神经活动和表现的研究表明，抑郁症与前额皮质（PFC）、前扣带皮层（ACC）和杏仁核等神经区域的功能障碍有关。其次，对健康参与者的研究表明，这些相同的神经区域与情绪调节直接相关。本提案描述了两个旨在整合这些研究路线的实验。在这两个实验中，参与者将尝试使用重新评估来调节他们对情绪负面刺激的反应，这是一种由皮质-扣带-杏仁核相互作用支持的适应性情绪调节策略。在重度抑郁症患者和健康对照进行重新评估时，将收集脑电图（EEG; Exp. 1）和功能磁共振成像（fMRI; Exp. 2）数据。结合脑电图和功能磁共振成像数据，将用于生成一个详细的重新评估的大脑机制的时空模型。这些数据还将用于验证一种假设，即重度抑郁症的情绪调节失败与特定神经区域的功能障碍有关，包括PFC外侧、ACC背侧和杏仁核。公共卫生相关性：通过确定抑郁症的核心过程——情绪调节，并将情绪调节失败与特定神经回路的功能障碍联系起来，拟议的研究将有助于阐明抑郁症的病理生理学。最终，这种方法可能有助于改善诊断和治疗。