Smart ventilated cage systems for next-level experimental design and monitoring of specialized animal models.

智能通风笼系统,用于下一级实验设计和专门动物模型的监测。

基本信息

  • 批准号:
    10737361
  • 负责人:
  • 金额:
    $ 33.8万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-07-01 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Murine models play a key role in a broad range of research areas given their comparable physiology to humans and other mammals, known genetic backgrounds, and the ease of their housing and maintenance. However, as we have gained a greater understanding of physiology, there has been a drive to create more sophisticated models that better represent human disease progression and response to treatments. This has led to the generation and use of mouse models with unique genetic backgrounds, behaviors, or susceptibility to diseases. While these models have been of enormous value, they require regular monitoring and may need special housing conditions (such as altered light/dark cycles) to maintain their health and successfully carry out needed research. Incorporating this monitoring adds significant operational burden on facility staff and researchers, and may also add to animal stress. Furthermore, even with increased physical monitoring of mice, important changes in health status can be missed during non-observational periods, making this a challenging problem to address. To address these issues, the Institute of Comparative Medicine (ICM) at Columbia University Irving Medical Center will acquire and install Tecniplast Digital Ventilated Cages (DVC) and Rack Environmental Monitoring modules for its specialized animal resources. The features of the DVC system will improve ICM operations by: 1) Providing automated, 24/7 remote monitoring of various parameters linked to animal welfare and environmental conditions of the animal facility; 2) triggering of automated alarms in particular conditions requiring immediate attention (e.g., decreased spontaneous mouse activity, water flooding, limited water bottle or food availability); 3) setting specific light/dark cycle for individual cages with the use of LEDDY units; and 4) reducing the number of cage changes needed in some circumstances (e.g. single-housed mice), reducing bedding waste. Implementation of DVC cages will be targeted toward specialized shared resources that utilize the most complex disease models, which will lead to a disproportionately large impact on animal welfare, facility operations, experimental capability of researchers, and the reproducibility and rigor of research within ICM.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

BRIAN KAROLEWSKI其他文献

BRIAN KAROLEWSKI的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('BRIAN KAROLEWSKI', 18)}}的其他基金

Comparative Medicine Center Upgrade
比较医学中心升级
  • 批准号:
    8185279
  • 财政年份:
    2012
  • 资助金额:
    $ 33.8万
  • 项目类别:

相似海外基金

Development of decellularized small-diameter arterial grafts and evaluation in large animal experiments
脱细胞小直径动脉移植物的研制及大动物实验评价
  • 批准号:
    21H03016
  • 财政年份:
    2021
  • 资助金额:
    $ 33.8万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Developing and validating a computational model of the gut microbiota-mucosa interactions to replace and reduce animal experiments
开发和验证肠道微生物群-粘膜相互作用的计算模型,以取代和减少动物实验
  • 批准号:
    NC/R001707/1
  • 财政年份:
    2018
  • 资助金额:
    $ 33.8万
  • 项目类别:
    Training Grant
Developing and validating a computational model of the gut microbiota-mucosa interactions to replace and reduce animal experiments
开发和验证肠道微生物群-粘膜相互作用的计算模型,以取代和减少动物实验
  • 批准号:
    2103295
  • 财政年份:
    2018
  • 资助金额:
    $ 33.8万
  • 项目类别:
    Studentship
Research on the way of information transmission to gain social understanding of animal experiments
动物实验获得社会理解的信息传递方式研究
  • 批准号:
    16K07080
  • 财政年份:
    2016
  • 资助金额:
    $ 33.8万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
CDS&E: Modeling the Zebrafish Model Organism Toward Reducing, Refining, and Replacing Animal Experiments
CDS
  • 批准号:
    1505832
  • 财政年份:
    2015
  • 资助金额:
    $ 33.8万
  • 项目类别:
    Standard Grant
Never replicate a successful experiment? Standardization, heterogenization and reproducibility in animal experiments
从未复制过成功的实验?
  • 批准号:
    283089959
  • 财政年份:
    2015
  • 资助金额:
    $ 33.8万
  • 项目类别:
    Research Grants
Arrhythmogenic Drug Evaluation System by Simplified Animal Experiments
简化动物实验的致心律失常药物评价系统
  • 批准号:
    26350520
  • 财政年份:
    2014
  • 资助金额:
    $ 33.8万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Promotion of the 4Rs in animal experiments by the development of a production process for polyclonal antibodies using a goldfish
开发金鱼多克隆抗体生产工艺,促进动物实验中的4R
  • 批准号:
    23650227
  • 财政年份:
    2011
  • 资助金额:
    $ 33.8万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Development of microangiographic systems to visualize cerebular perforating artery in clinical settings and retrobulbar ophthalmic artery arteries in animal experiments.
开发显微血管造影系统,以在临床环境中可视化小脑穿支动脉,并在动物实验中可视化球后眼动脉。
  • 批准号:
    23390305
  • 财政年份:
    2011
  • 资助金额:
    $ 33.8万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
The study for the modification of cerebral synapses by balance exercises in the elderly based on animal experiments.
基于动物实验的老年人平衡运动改变大脑突触的研究。
  • 批准号:
    21500471
  • 财政年份:
    2009
  • 资助金额:
    $ 33.8万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了