ISU Vet-LIRN Infrastructure Grant Proposal

项目概要 拟议的工作是为了爱荷华州立大学之间的合作协议 兽医诊断实验室 (ISU-VDL) 和 FDA 兽医中心 Vet- LIRN 计划在以下领域提供支持： 1) 参与 FDA/Vet-LIRN 认可的化学污染物样品分析。 2) 提供分析数据以支持潜在的监管用途。 3) 参与其他项目，如小规模方法开发、方法 用于化学污染物分析的验证和矩阵扩展。 4) 作为源实验室参与 Vet-LIRN AMR 监测计划。 这些活动旨在支持 FDA 加强兽医部门的协调 诊断实验室在加强国家食品安全体系方面的努力。 ISU-VDL 是一家获得 AAVLD 完全认可的全方位服务实验室，可提供切割- 为爱荷华州及其他地区提供边缘诊断服务。 ISU-VDL 的案例负载为 在全国独一无二，因为它主要与食品动物有关。爱荷华州是主要食物 动物生产国。实验室不仅是食品领域的第一道防线 全国各地食用动物生产者的安全，但也大力参与保护 伴侣动物健康。该项目将专门解决与化学相关的问题 污染导致动物患病或死亡。我们大量的食用动物 爱荷华州的产品出口到海外的欧盟和亚洲市场，这些市场对 食品安全。参与这一合作协议计划不仅有利于FDA， 但实验室和爱荷华州也是如此，因为这个项目的各个方面都为我们增加了价值 产品，即准确、及时分析检测结果，保护动物和人类健康 免受化学污染物的影响。 ISU-VDL 设备精良，人员配备齐全，可以积极影响 FDA 的需求（如概述） 在FOA中。具体来说，我们拥有必要的基础设施来支持培训、参与 质量保证流程和能力测试，并共享数据以支持国家能力 发展。我们将快速准确地测试诊断样本，以协助 FDA 应对情况 调查。作为粮食紧急响应的成员和长期参与者 网络 (FERN) 以及作为 Vet-LIRN 的创始成员，我们已经证明我们 拥有准确有效地报告结果的基础设施。我们的工作质量 产品由独立的质量保证部门监督。总而言之，我们有 及时交付我们的工作产品的资源和基础设施。我们准备好 如果申请成功，请与 FDA 合作开展此项拨款。

Project Summary The proposed work is for a cooperative agreement between the Iowa State University Veterinary Diagnostic Laboratory (ISU-VDL) and the FDA Center for Veterinary Medicine Vet- LIRN program to provide support in the following areas: 1) To participate in FDA/Vet-LIRN sanctioned sample analysis for chemical contaminants. 2) To provide analytical data to support potential regulatory use. 3) To participate in additional projects such as small scale methods development, method validation, and matrix extension for analysis of chemical contaminants. 4) To participate in the Vet-LIRN AMR Monitoring Program as a source laboratory. These activities are designed to support the FDA in strengthening coordination of veterinary diagnostic laboratory efforts in enhancing the national food safety system. The ISU-VDL is a full-service laboratory, fully accredited by the AAVLD, which provides cutting- edge diagnostic services to the State of Iowa and beyond. The case load at the ISU-VDL is unique in the nation because it is predominantly food-animal related. Iowa is a major food animal producing state. The laboratory is not only the first line of defense in the area of food safety to food animal producers across the country, but is also heavily engaged in protection of companion animal health. This project will specifically address issues related to chemical contamination leading to animal illnesses or death. A significant amount of our food animal products from Iowa are exported overseas to the EU and Asia markets which are sensitive to food safety. Participation in this cooperative agreement program will not only benefit the FDA, but the lab and the State of Iowa as well because all aspects of this project add value to our product, namely, accurate and timely analysis of test results to protect animal and human health from chemical contaminants. The ISU-VDL is well-equipped and staffed to positively impact the needs of the FDA as outlined in the FOA. Specifically, we have the necessary infrastructure to support training, participate in quality assurance processes and proficiency tests, and share data to support national capacity development. We will quickly and accurately test diagnostic samples to assist the FDA in case investigations. As members and long-term participants in the Food Emergency Response Network (FERN) and also as founding members of Vet-LIRN, we have demonstrated that we have the infrastructure to report out results accurately and efficiently. The quality of our work product is overseen by an independent Quality Assurance Unit. In summary, we have the resources and infrastructure to deliver our work product in a timely manner. We are ready to collaborate with the FDA on this grant if the application is successful.