ISU Vet-LIRN Infrastructure Grant Proposal

项目摘要 拟议的工作是为爱荷华州州立大学之间的合作协议 兽医诊断实验室（ISU-VDL）和FDA兽医中心 LIRN计划在以下领域提供支持： 1)参与FDA/Vet-LIRN批准的化学污染物样品分析。 2)提供分析数据以支持潜在的监管用途。 3)参与其他项目，如小规模方法开发，方法 验证和矩阵扩展，用于化学污染物的分析。 4)作为源实验室参与Vet-LIRN AMR监测计划。 这些活动旨在支持FDA加强兽医协调， 诊断实验室努力加强国家食品安全系统。 ISU-VDL是一个全方位服务的实验室，完全由AAVLD认证，提供切割- 为爱荷华州及其他地区提供边缘诊断服务。ISU-VDL的箱负载为 这在美国是独一无二的，因为它主要与食用动物有关。爱荷华州是一个主要的食物 动物生产国。实验室不仅是食品领域的第一道防线 全国各地的食用动物生产者的安全，但也大量从事保护， 伴侣动物健康该项目将具体处理与化学品有关的问题， 污染导致动物生病或死亡。大量的食用动物 来自爱荷华州的产品出口到海外的欧盟和亚洲市场，这些市场对 食品安全参与这项合作协议计划不仅有利于FDA， 而且实验室和爱荷华州也是如此，因为这个项目的各个方面都为我们的 产品，即准确和及时地分析测试结果，以保护动物和人类健康 化学污染物。 ISU-VDL设备齐全，人员配备齐全，能够积极满足FDA的需求， 在FOA。具体来说，我们有必要的基础设施来支持培训，参与 质量保证程序和能力测试，并分享数据以支持国家能力 发展我们将快速准确地检测诊断样本，以协助FDA， 调查事务所作为粮食紧急反应的成员和长期参与者， 作为Vet-LIRN的创始成员，我们已经证明， 拥有准确有效地报告结果的基础设施。我们的工作质量 产品由独立的质量保证部门监督。总之，我们有 资源和基础设施，以及时交付我们的工作产品。我们准备 如果申请成功，请与FDA合作。

Project Summary The proposed work is for a cooperative agreement between the Iowa State University Veterinary Diagnostic Laboratory (ISU-VDL) and the FDA Center for Veterinary Medicine Vet- LIRN program to provide support in the following areas: 1) To participate in FDA/Vet-LIRN sanctioned sample analysis for chemical contaminants. 2) To provide analytical data to support potential regulatory use. 3) To participate in additional projects such as small scale methods development, method validation, and matrix extension for analysis of chemical contaminants. 4) To participate in the Vet-LIRN AMR Monitoring Program as a source laboratory. These activities are designed to support the FDA in strengthening coordination of veterinary diagnostic laboratory efforts in enhancing the national food safety system. The ISU-VDL is a full-service laboratory, fully accredited by the AAVLD, which provides cutting- edge diagnostic services to the State of Iowa and beyond. The case load at the ISU-VDL is unique in the nation because it is predominantly food-animal related. Iowa is a major food animal producing state. The laboratory is not only the first line of defense in the area of food safety to food animal producers across the country, but is also heavily engaged in protection of companion animal health. This project will specifically address issues related to chemical contamination leading to animal illnesses or death. A significant amount of our food animal products from Iowa are exported overseas to the EU and Asia markets which are sensitive to food safety. Participation in this cooperative agreement program will not only benefit the FDA, but the lab and the State of Iowa as well because all aspects of this project add value to our product, namely, accurate and timely analysis of test results to protect animal and human health from chemical contaminants. The ISU-VDL is well-equipped and staffed to positively impact the needs of the FDA as outlined in the FOA. Specifically, we have the necessary infrastructure to support training, participate in quality assurance processes and proficiency tests, and share data to support national capacity development. We will quickly and accurately test diagnostic samples to assist the FDA in case investigations. As members and long-term participants in the Food Emergency Response Network (FERN) and also as founding members of Vet-LIRN, we have demonstrated that we have the infrastructure to report out results accurately and efficiently. The quality of our work product is overseen by an independent Quality Assurance Unit. In summary, we have the resources and infrastructure to deliver our work product in a timely manner. We are ready to collaborate with the FDA on this grant if the application is successful.