HIGHLY ATTENUATED SIV VIF DNA VACCINES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：慢病毒的辅助基因vif是病毒高效复制所必需的。VIF通过靶向蛋白酶体降解来抑制细胞胞苷脱氨酶APOBEC3G的病毒粒子掺入。VIF缺失的病毒可能在宿主中持续存在，尽管水平极低，并仅限于APOBEC3蛋白表达减少的特定组织或细胞亚群。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The accessory gene vif of lentiviruses is required for efficient viral replication. Vif inhibits virion incorporation of a cellular cytidine deaminase, APOBEC3G, by targeting this cellular protein for proteosomal degradation. A vif-deleted virus may be persistent in the host, although at extremely low levels and restricted to specific tissues or cell subsets with reduced expression of APOBEC3 proteins.