Colon Cancer Screening Using Elastic Light Scattering Spectroscopy

使用弹性光散射光谱进行结肠癌筛查

• 批准号: 7679463
• 负责人: JACQUES VAN DAM
• 金额: $ 18.47万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-25 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7679463
• 关键词: Biomedical Engineering; Biophotonics; Clinical; Clinical Research; Collaborations; Colon Carcinoma; Colonoscopy; Colorectal Cancer; Colorectal Neoplasms; Faculty; Fingerprint; Four-dimensional; Funding; Goals; Grant; Health Care Costs; Image; Instruction; Light-Scattering Spectroscopy; Malignant Neoplasms; Medical Faculty; Mentors; Methodology; Neoplasms; Patients; Physicians; Population; Principal Investigator; Procedures; Research; Research Personnel; Risk; Scientist; Screening for cancer; Screening procedure; Spectrum Analysis; Stratification; System; Systems Analysis; Techniques; Time; Training; United States National Institutes of Health; Universities; Validation; Wages; base; colorectal cancer screening; disorder risk; improved; light scattering; next generation; novel; patient oriented research; quantum

DESCRIPTION (provided by applicant): The goal of this competitive renewal is to provide continued salary support to facilitate the advancement and completion of patient-oriented research and the continued mentoring of trainees and junior faculty in endoscopic patient-oriented research. The Principal Investigator is a clinically-active [sic], NIH-funded physician scientist and a collaborator on an important study to develop an office-based clinical system to detect patients at risk for colorectal neoplasia (colorectal cancer) using two newly-developed light-based, spectroscopic techniques. The two techniques are low-coherence enhanced backscattering (LEBS) spectroscopy and four-dimensional elastic light scattering fingerprinting (ELF). Together, these light-based imaging systems have the potential to dramatically improve cancer screening by determining prior to colonoscopy, which patients may actually be at risk for colorectal neoplasia. By doing so, the number of patients screened via colonoscopy could be drastically reduced by eliminating this procedure for patients who are not capable of forming cancer or cancer precursors. The overall reduction in health care costs (both direct and indirect) by targeting colonoscopy for only those patients at risk for the disease would be staggering. This proposal supports a Bioengineering Research Partnership (BRP) in collaboration with investigators and colleagues at Northwestern University. The BRP is supported by the NIH (two R21's, three R01's and a U01 grants). Dr. Vadim Backman and his group have developed and analyzed the systems and performed preliminary clinical studies on a number of biophotonics techniques that promises to have unprecedented accuracy in risk stratification of colonic neoplasia. The major objective of the BRP is to refine and provide comprehensive, definitive multi-center validation of these novel methodologies for colorectal cancer (CRC) screening, thus providing a quantum leap in population screening. The major objective of the K24 is to provide the PI support for time to devote to patient-oriented research (POR) and to act as a research mentor for clinical residents, clinical fellows and/or junior medical faculty. The Principal Investigator is devoted to training clinical researchers and will continue the formalized instruction and mentoring of young clinicians so that they may successfully engage in meaningful independent patient-oriented research. In this way, the PI will help mentor the next generation of physician scientists.

描述（由申请人提供）： 这种竞争性更新的目标是提供持续的工资支持，以促进推进和完成以患者为导向的研究，并继续指导学员和初级教师在内窥镜以患者为导向的研究。主要研究者是一位临床活跃的NIH资助的医生科学家，也是一项重要研究的合作者，该研究旨在开发一种基于办公室的临床系统，使用两种新开发的基于光的光谱技术检测具有结直肠肿瘤（结直肠癌）风险的患者。这两种技术是低相干增强后向散射（LEBS）光谱和四维弹性光散射指纹（ELF）。总之，这些基于光的成像系统有可能通过在结肠镜检查之前确定哪些患者实际上可能有结肠直肠肿瘤的风险来显着改善癌症筛查。通过这样做，通过结肠镜检查筛查的患者数量可以通过消除不能够形成癌症或癌症前体的患者的这种程序而大大减少。通过只针对那些有患病风险的患者进行结肠镜检查，整体医疗费用（直接和间接）的减少将是惊人的。该提案支持与西北大学的研究人员和同事合作的生物工程研究伙伴关系（BRP）。BRP由NIH支持（两个R21，三个R 01和一个U 01赠款）。Vadim Backman博士和他的团队已经开发和分析了这些系统，并对一些生物光子学技术进行了初步临床研究，这些技术有望在结肠肿瘤的风险分层方面具有前所未有的准确性。BRP的主要目标是完善并提供这些用于结直肠癌（CRC）筛查的新方法的全面，明确的多中心验证，从而在人群筛查中实现飞跃。K24的主要目标是为PI提供时间支持，以致力于以患者为导向的研究（POR），并担任临床住院医师，临床研究员和/或初级医学教师的研究导师。主要研究者致力于培训临床研究人员，并将继续对年轻临床医生进行正式的指导和指导，使他们能够成功地从事有意义的独立的以患者为导向的研究。通过这种方式，PI将帮助指导下一代医生科学家。