EXERCISE AND NICOTINE REPLACEMENT FOR FEMALE SMOKERS

女性吸烟者的锻炼和尼古丁替代

• 批准号: 7606236
• 负责人: FRANK M PERNA
• 金额: $ 26.36万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-03 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606236
• 关键词: Adherence; Behavioral; Biochemical; Blood; Body Composition; Characteristics; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Condition; Counseling; DEXA; Drug Addiction; Exclusion; Exercise; Exercise stress test; Female; Funding; Grant; Home environment; Individual; Institution; Instruction; Intervention; Medical; Moods; Nicotine; Participant; Patient Self-Report; Questionnaires; Randomized; Research; Research Personnel; Resources; Scanning; Screening procedure; Smoker; Smoking Status; Source; Structure; Surveys; Training; United States National Institutes of Health; Visit; Week; Withdrawal Symptom; base; day; follow-up; nicotine patch; nicotine replacement; programs; psychosocial

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Participants will be followed from 3 weeks before quitting through one year after the quit day. Participants will receive nicotine transdermal patch treatment (21mg/24hr.). 270 participants will be randomly assigned to receive a facility-based, supervised exercise intervention, and 270 participants will be assigned to a home-based structured exercise program. One-half of the participants assigned to the facility-based exercise sessions and one-half of those in the home-based condition will be assigned to receive additional cognitive-behavioral counseling aimed at increasing exercise adherence. The remaining 270 participants will not receive exercise adherence counseling, only brief exercise instruction. Every participant will undergo a graded exercise test, medical screening, complete psychosocial surveys, a blood draw, and DEXA scan for body composition during her first precessation visit. Each individual whose screening shows no contraindications to the use of nicotine patch, exercise testing and training, and who completes exercise testing and baseline questionnaires, will be randomly assigned to one of the four treatment conditions. Additional exclusions include active severe psychiatric illness and drug dependence. The exercise treatments will begin 3 weeks prior to the quit day and continue until 12 weeks after the quit day. All 540 participants will have 2 precessation visits, at 3 weeks and 1 week before the quit day, and will have regular postcessation follow-ups at 1,2,4,8,12,16,26,39, and 52 weeks after quitting. Follow-up visits will include questions regarding cessation progress, withdrawal symptoms and mood assessments, and reassessment of baseline characteristics such as commitment to cessation and biochemical verification of self-reported smoking status.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 将从戒烟前三周到戒烟日后一年对参与者进行跟踪。参与者将接受尼古丁透皮贴剂治疗（21 毫克/24 小时）。 270 名参与者将被随机分配接受基于设施的监督锻炼干预，270 名参与者将被分配到家庭结构化锻炼计划。一半被分配到设施锻炼课程的参与者和一半在家条件下的参与者将被分配接受额外的认知行为咨询，旨在提高锻炼依从性。其余 270 名参与者将不会接受运动坚持咨询，仅接受简短的运动指导。每位参与者在第一次进动访问期间都将接受分级运动测试、医疗筛查、完整的心理社会调查、抽血和 DEXA 身体成分扫描。每个经过筛查显示没有使用尼古丁贴片、运动测试和训练禁忌症并且完成运动测试和基线调查问卷的个体将被随机分配到四种治疗条件之一。其他排除包括活动性严重精神疾病和药物依赖。运动治疗将从戒烟日前 3 周开始，一直持续到戒烟日后 12 周。所有 540 名参与者将在戒烟日前 3 周和 1 周进行 2 次戒烟前访视，并将在戒烟后 1、2、4、8、12、16、26、39 和 52 周定期进行戒烟后随访。随访将包括有关戒烟进展、戒断症状和情绪评估的问题，以及基线特征的重新评估，例如戒烟承诺和自我报告吸烟状况的生化验证。