EXERCISE AND NICOTINE REPLACEMENT FOR FEMALE SMOKERS

女性吸烟者的锻炼和尼古丁替代

• 批准号: 7379490
• 负责人: FRANK M PERNA
• 金额: $ 21.39万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379490
• 关键词: EXERCISE; NICOTINE; REPLACEMENT; FEMALE; SMOKERS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Overcoming tobacco use and nicotine dependence, one of the main cardiovascular risk factors, appears to be more difficult for women than for men, mainly because 1) women may be more sensitive to the effects of nicotine than men; 2) negative affectivity that is associated with continued tobacco use is more common among women than men; and 3) women have more concerns about weight as a reason for continuing smoking and not attempting to quit. The combination of an exercise intervention with nicotine replacement therapy (NRT) should provide a particularly efficacious and cost-effective treatment for female smokers. In our ongoing study, we have found that aerobic exercise, held in a supervised hospital setting, and used as an adjust to NRT, has produced higher quit rates than standard care with NRT. However, relapse was still very rapid and adherence to the exercise regimen was less than optimal. Exercise adherence was particularly poor among those who had higher body mass index, higher nicotine dependence, and depression prior to quitting, i.e., those with high cardiovascular risk index. Increasing the adherence to the exercise might result in improved cessation rates, concurrently reducing cardiovascular risk factors and, in turn, female morbidity and mortality. The proposed study will investigate if cognitive-behavioral exercise adherence counseling (CBC) added to an exercise prescription (ERX), used effectively in many patient-populations, increases engagement in physical exercise among female smokers attempting to quit compared to an ERX alone condition. We will examine if increased exercise adherence results in higher cessation rates, and whether prescribed exercise that is home-based (HB) would result in the same cessation effects as an exercise program that is facility-based (FB).

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。克服烟草使用和尼古丁依赖是主要的心血管风险因素之一，对女性来说似乎比男性更困难，主要是因为1）女性可能比男性对尼古丁的影响更敏感; 2）与持续吸烟相关的负面情绪在女性中比男性更常见; 3）女性更担心体重是继续吸烟和不试图戒烟的原因。运动干预与尼古丁替代疗法（NRT）相结合，应为女性吸烟者提供特别有效和具有成本效益的治疗。在我们正在进行的研究中，我们发现，在有监督的医院环境中进行有氧运动，并用作NRT的调整，比NRT的标准护理产生了更高的戒烟率。 然而，复发仍然非常迅速，坚持运动方案是不够理想的。在那些体重指数较高、尼古丁依赖程度较高和戒烟前抑郁的人中，运动坚持性特别差，即，心血管风险指数高的人。增加坚持锻炼可能会提高戒烟率，同时减少心血管危险因素，从而降低女性发病率和死亡率。这项拟议的研究将调查是否认知行为运动坚持咨询（CBC）添加到运动处方（ERX）中，在许多患者人群中有效使用，与ERX单独条件相比，增加试图戒烟的女性吸烟者参与体育锻炼。我们将检查是否增加运动坚持导致更高的戒烟率，以及是否规定的运动是以家庭为基础的（HB）将导致相同的戒烟效果作为一个运动计划是以设施为基础的（FB）。