EXERCISE EFFECTS ON MENTAL AND PHYSICAL HEALTH IN BREAST CANCER

运动对乳腺癌患者心理和身体健康的影响

• 批准号: 7379457
• 负责人: FRANK M PERNA
• 金额: $ 3.28万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379457
• 关键词: EXERCISE; EFFECTS; MENTAL; PHYSICAL; HEALTH

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Within their lifetime, 1 in 8 women will be diagnosed with breast cancer, and the degree of psychological distress and impairment in physical functioning accompanying diagnoses and treatments have been prospectively related to quality of life (QOL) and morbidity. While prior work suggests that exercise may enhance mental and physical health, the efficacy of exercise to promote psychological and physical functioning has not been adequately assessed nor have factors related to exercise compliance been investigated. Over a 5-year period, we will implement an exercise intervention and evaluate its effects on psychological distress, fitness, body composition, and QOL among stage I and II breast cancer patients. Lastly, we will also evaluate the pathways, which may mediate exercise effects on QOL and assess exercise adherence factors. Women (N=140) drawn from Boston University Medical Center's Women's Health Group and the surrounding communities will be randomly assigned to either a 1-year exercise intervention or a control condition with assessments at baseline, 3, 6, and 12 months. Assessments will consist of a graded exercise test assessing cardiovascular fitness, body composition analysis, strength testing, and a psychosocial survey assesssing psychological distress and QOL for which women will be compensated $160 over four assessments. Exercise group participants will be provided individualized walking and resistance training exercise programs inclusive of laboratory monitored and home-based phases. The intervention will also utilize cognitive-behavioral techniques such as contingency planning, goal setting, and self-monitoring to promote exercise adherence. The education-standard of care control group will be provided with general information regarding healthy lifestyle management (i.e. effects of exercise, diet, and stress management), but will not receive a formal exercise prescription nor undergo the intervention experience in solidifying and acting on this information. Beyond comprehensively testing the efficacy of a low cost exercise intervention to promote physical and mental health, the project will also generate information that may be useful for promoting exercise among persons of low income who are at relatively greater risk for cancer morta

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。在她们的一生中，每8名妇女中就有1人会被诊断为乳腺癌，而伴随诊断和治疗而来的心理痛苦和身体功能损害的程度预计与生活质量(QOL)和发病率有关。虽然先前的研究表明，运动可以增进心理和身体健康，但运动促进心理和身体功能的有效性尚未得到充分评估，也没有调查与运动依从性有关的因素。在为期5年的时间里，我们将实施一项运动干预，并评估其对I期和II期乳腺癌患者的心理困扰、健康状况、身体成分和生活质量的影响。最后，我们还将评估可能中介运动对生活质量影响的途径，并评估运动依从性因素。来自波士顿大学医学中心妇女健康小组和周围社区的女性(N=140)将被随机分配到为期一年的运动干预或对照条件下，评估时间分别为基线、3个月、6个月和12个月。评估将包括评估心血管健康状况的分级运动测试、身体成分分析、力量测试，以及评估心理困扰和生活质量的心理社会调查，女性将在四次评估中获得160美元的补偿。将为运动组参与者提供个性化的步行和阻力训练练习计划，包括实验室监测和家庭阶段。干预还将利用认知行为技术，如应急计划、目标设定和自我监控来促进锻炼坚持。教育标准的护理控制组将被提供关于健康生活方式管理的一般信息(即锻炼、饮食和压力管理的效果)，但不会收到正式的运动处方，也不会接受巩固和根据这些信息采取行动的干预经验。除了全面测试低成本运动干预措施促进身心健康的效果外，该项目还将产生一些信息，可能有助于在低收入人群中促进运动，这些人患癌症死亡的风险相对较高。