ANDROGEN RECEPTOR CAG REPEAT POLYMORPHISM & HYPOTHALAMIC SEX STEROID SENSITIVITY
ANDROGEN RECEPTOR CAG REPEAT POLYMORPHISM & HYPOTHALAMIC SEX STEROID SENSITIVITY
批准号:
7606698
负责人:
John C Marshall
金额:
$1.25万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-03-01 至 2008-02-29
关键词:
AdolescentAdultAndrogen ReceptorAndrogensCAG repeatComputer Retrieval of Information on Scientific Projects DatabaseEthnic groupFemale AdolescentsFlutamideFundingGenetic PolymorphismGenetic Predisposition to DiseaseGonadal Steroid HormonesGrantHispanicsHypothalamic structureInstitutionLengthMediatingNeurosecretory SystemsPlayPolycystic Ovary SyndromePredispositionProgesteroneResearchResearch PersonnelResourcesRoleSourceTransactivationUnited States National Institutes of HealthWomangirlsracial and ethnic
中文摘要
这个子项目是许多研究子项目中利用
资源由NIH/NCRR资助的中心拨款提供。子项目和
调查员(PI)可能从NIH的另一个来源获得了主要资金,
并因此可以在其他清晰的条目中表示。列出的机构是
该中心不一定是调查人员的机构。
青少年高雄激素血症似乎是成人多囊卵巢综合征(PCOS)的先兆。患有多囊卵巢综合征的成年女性对孕激素抑制GnRH搏动性的敏感性降低。雄激素似乎在调节孕激素敏感性方面发挥了作用,因为使用雄激素阻滞剂氟他胺可以恢复敏感性。我们发现,一些高雄激素血症的青春期女孩对孕激素抑制GnRH搏动性的敏感性降低,而另一些女孩尽管雄激素水平相当,但仍保持敏感性。所有保持孕激素敏感性的高雄激素血症女孩都是西班牙裔,这表明可能是遗传原因。雄激素受体CAG重复长度多态性赋予不同的雄激素受体反式激活活性。雄激素受体CAG重复长度多态性在不同种族和民族中的分布存在差异。
我们建议在对孕激素抑制GnRH搏动性敏感和不敏感的高雄激素血症青春期女孩中检测雄激素受体CAG重复长度。这一结果将使我们能够确定雄激素受体CAG重复序列多态性是否在决定高雄激素血症神经内分泌效应的易感性中发挥作用。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Adolescent hyperandrogenemia appears to be a precursor to adult polycystic ovary syndrome (PCOS). Adult women with PCOS have reduced sensitivity to progesterone inhibition of GnRH pulsatility. Androgens appear to play a role in mediating progesterone sensitivity, as sensitivity can be restored with the use of the androgen blocker flutamide. We have found that some hyperandrogenemic adolescent girls show reduced sensitivity to progesterone inhibition of GnRH pulsatility while others maintain sensitivity despite equivalent androgen levels. All of the hyperandrogenemic girls who maintained progesterone sensitivity were Hispanic, suggesting a possible genetic etiology. Androgen receptor CAG repeat length polymorphisms confer variable androgen receptor transactivation activities. The distribution of androgen receptor CAG repeat length polymorphism varies in different racial and ethnic groups.
We propose to examine the androgen receptor CAG repeat length in hyperandrogenemic adolescent girls with and without sensitivity to progesterone inhibition of GnRH pulsatility. The results will allow us to determine whether androgen receptor CAG repeat polymorphisms play a role in determining susceptibility to the neuroendocrine effects of hyperandrogenemia.
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会议论文
CRR LIGAND ASSAY AND ANALYSIS CORE
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批准号:10017063
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项目类别:
-
资助金额:$44.4万
-
财政年份:2019
-
负责人:John C Marshall
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依托单位:
Clinical and Basic Studies in Polycystic Ovarian Syndrome
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批准号:8081160
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项目类别:
-
资助金额:$4.7万
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财政年份:2010
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负责人:John C Marshall
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依托单位:
METFORMIN AND SENSITIVITY OF GNRH PULSE GENERATOR SUPPRESSION IN HYPERANDROGEMIA
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批准号:8167194
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项目类别:
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资助金额:$4.01万
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财政年份:2010
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负责人:John C Marshall
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依托单位:
ANDROGEN BLOCKADE AND SENSITIVITY OF THE GNRH PULSE GENERATOR
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批准号:8167167
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项目类别:
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资助金额:$1.2万
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财政年份:2010
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负责人:John C Marshall
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依托单位:
PROGESTERONE INHIBITION OF GNRH PULSATILITY IN ADOLESCENT GIRLS
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批准号:8167209
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项目类别:
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资助金额:$1.47万
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财政年份:2010
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负责人:John C Marshall
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依托单位:
PROGESTERONE AND LH ACROSS PUBERTY IN GIRLS WITH/WITHOUT HYPERANDROGENEMIA
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批准号:8167186
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项目类别:
-
资助金额:$2.0万
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财政年份:2010
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负责人:John C Marshall
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依托单位:
ADRENAL ANDROGEN PRODUCTION IN NORMAL AND OBESE GIRLS
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批准号:8167166
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项目类别:
-
资助金额:$3.74万
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财政年份:2010
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负责人:John C Marshall
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依托单位:
INTRAGONADOTROPE PATHWAYS REGULATING GENE TRANSCRIPTION
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批准号:8099327
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项目类别:
-
资助金额:$9.06万
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财政年份:2010
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负责人:John C Marshall
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依托单位:
PROGESTERONE INHIBITION OF GNRH PULSATILITY IN ADOLESCENT GIRLS
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批准号:7951520
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项目类别:
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资助金额:$5.26万
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财政年份:2009
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负责人:John C Marshall
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依托单位:
ANDROGEN BLOCKADE AND SENSITIVITY OF THE GNRH PULSE GENERATOR
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批准号:7951489
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项目类别:
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资助金额:$0.78万
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财政年份:2009
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负责人:John C Marshall
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依托单位:
PROGESTERONE AND LH ACROSS PUBERTY IN GIRLS WITH/WITHOUT HYPERANDROGENEMIA
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批准号:7951513
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项目类别:
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资助金额:$1.07万
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财政年份:2009
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负责人:John C Marshall
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依托单位:
PROJECT 1 - TESTOSTERONE - GnRH PULSE FREQUENCY AND THE EVOLUTION OF PCOS IN ADOL
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批准号:7683449
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项目类别:
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资助金额:$31.84万
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财政年份:2009
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负责人:John C Marshall
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依托单位:
ADRENAL ANDROGEN PRODUCTION IN NORMAL AND OBESE GIRLS
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批准号:7951487
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项目类别:
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资助金额:$4.48万
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财政年份:2009
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负责人:John C Marshall
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依托单位:
Clinical and Basic Studies in Polycystic Ovarian Syndrome
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批准号:7863981
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项目类别:
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资助金额:$0.68万
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财政年份:2009
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负责人:John C Marshall
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依托单位:
METFORMIN AND SENSITIVITY OF GNRH PULSE GENERATOR SUPPRESSION IN HYPERANDROGEMIA
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批准号:7951518
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项目类别:
-
资助金额:$0.29万
-
财政年份:2009
-
负责人:John C Marshall
-
依托单位:
ANDROGEN RECEPTOR CAG REPEAT POLYMORPHISM & HYPOTHALAMIC SEX STEROID SENSITIVITY
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批准号:7951468
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项目类别:
-
资助金额:$0.2万
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财政年份:2009
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负责人:John C Marshall
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依托单位:
Clinical and Basic Studies in Polycystic Ovarian Syndrome
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批准号:7930047
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项目类别:
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资助金额:$5.0万
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财政年份:2009
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负责人:John C Marshall
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依托单位:
CORE A - ADMINISTRATIVE CORE
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批准号:7683459
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项目类别:
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资助金额:$22.18万
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财政年份:2009
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负责人:John C Marshall
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依托单位:
ANDROGEN RECEPTOR CAG REPEAT POLYMORPHISM & HYPOTHALAMIC SEX STEROID SENSITIVITY
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批准号:7718551
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项目类别:
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资助金额:$0.52万
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财政年份:2008
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负责人:John C Marshall
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依托单位:
ANDROGEN RECEPTOR CAG REPEAT POLYMORPHISM AND SERUM ANDROGEN IN ADOLESCENT GIRLS
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批准号:7718557
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项目类别:
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资助金额:$1.47万
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财政年份:2008
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负责人:John C Marshall
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依托单位:
海外基金