FAT REDISTRIBUTION AND METABOLIC CHANGE IN HIV INFECTION: PROTOCOL 2 (FRAM 2)

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: #1: To measure carotid IMT in years 4-5 of the FRAM study and compare results in HIV+ subjects to control subjects from the CARDIA and MESA cohorts with adjustment for HIV independent risk factors, such as age, sex, race and smoking. To address this aim, we will model IMT as a function of HIV status, age, gender, ethnicity, and smoking. An additional predictor will indicate which control group (CARDIA or MESA) the subject belongs to, and we will also examine separate comparisons of HIV+ to each control group, with the HIV+ group restricted to those in the same age range as the controls.