EFFECTS OF TOTAL SLEEP DEPRIVATION AND RECOVERY SLEEP ON BRAIN FUNCTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的1：测定健康志愿者在全睡眠剥夺(TSD)前、中、后不同时间点的血氧水平依赖对比(BOLD)脑局部变化。 目的：研究TSD和时间对大脑对认知需求的大胆反应的联合作用。 目的：评价大脑对认知需求的大胆反应随着任务时间的增加而发生的变化，并确定任务时间与TSD如何相互作用来影响大脑反应。 目的：为了确定1或2个晚上的恢复睡眠是否逆转了TSD对大脑对认知需求的大胆反应的影响。 目的5：检验重复认知测试对本研究中使用的脑功能fMRI测量的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Aim 1: To determine regional brain changes in blood oxygen level dependent(BOLD) contrast during cognitive performance at several time points before, during and after 62 hours of total sleep deprivation (TSD) in healthy volunteers. Aim2: To examine the joint effects of TSD and time of day on cerebral BOLD response to cognitive demands. Aim3: To evaluate changes in cerebral BOLD response to cognitive demands with increasing time on task and to determine how time on task interacts with TSD to influence cerebral response. Aim4: To determine if 1 or 2 nights of recovery sleep reverse the effects of TSD on cerebral BOLD response to cognitive demands. Aim 5: To examine the effects of repeated cognitive testing on the FMRI measures of brain function used during this study.